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    Home > Biochemistry News > Biotechnology News > Zhang Chuanmao Laboratory of the School of Life Sciences reveals the molecular mechanism of the microtubule-associated protein NuMA regulating the length and dynamics of the spindle through phase separation

    Zhang Chuanmao Laboratory of the School of Life Sciences reveals the molecular mechanism of the microtubule-associated protein NuMA regulating the length and dynamics of the spindle through phase separation

    • Last Update: 2021-12-27
    • Source: Internet
    • Author: User
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    On December 9, 2021, Professor Zhang Chuanmao's laboratory at Peking University's School of Life Sciences published a work entitled " Numa regulates mitotic spindle assembly, structural dynamics and function via phase separation " in Nature Communications


    The spindle is an important temporary organelle in eukaryotic cells, which regulates the separation of sister chromatids and the direction of cell division


    In recent years, the study of membraneless organelles formed by phase separation has proposed a new direction for the regulation of spindles


    As an important microtubule binding protein, NuMA plays an important function in the assembly and organization of the spindle


    Further research found that NuMA undergoes a liquid-liquid phase separation process during mitosis


    Figure 1.


    Subsequent functional studies found that the agglutination of NuMA on the spindle pole regulates the spatial positioning of Kif2A on the spindle pole, isolates Kif2A on the spindle pole, and depolymerizes the microtubules on the spindle pole, thereby regulating the microtubules.


    In summary, this work took NuMA protein as the starting point for research, clarified the specific mechanism of NuMA regulating spindle length and dynamics, and provided important information for understanding the underlying mechanism of spindle assembly and dynamic regulation


    Figure 2.


    Professor Zhang Chuanmao is the corresponding author of this paper, and Mengjie Sun, a doctoral student in Zhang Chuanmao's laboratory, is the first author of this paper.



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