Zhang Jiwen, researcher team and collaborator of Shanghai Institute of pharmaceutical research, Chinese Academy of Sciences: preparation of ultrafine silver nanoparticles for antibacterial and wound repair with cyclodextrin metal organic framework

Controlling bacterial infection is the first challenge in the process of trauma treatment Silver nanoparticles (Ag NPs) can effectively control the growth of bacteria in the wound Therefore, to improve the activity of antibacterial agents such as Ag NPs and adopt the strategy of hemostasis and antibacterial double treatment can not only avoid the abuse of antibiotics, but also meet a large number of medical needs However, the size of Ag NPs obtained by conventional loading method is too large, the physical stability is poor, and it is easy to aggregate and agglomerate, which limits its clinical application Using cd-mof as template, Zhang Jiwen, researcher team of Shanghai Institute of pharmaceutical research, Chinese Academy of Sciences, synthesized stable Ag NPs, which achieved higher antibacterial activity and effectively promoted hemostasis and wound healing after functional modification In this study, cd-mof (Ag @ cd-mof) loaded with ultra-fine Ag NPs was synthesized by using cd-mof, a biocompatible material, as a template, and using the 1.7nm small space in cd-mof to limit the growth of Ag NPs Compared with the existing Ag NPs products, Ag @ cd-mof has good stability and stronger antibacterial ability The results showed that Ag @ cd-mof could inhibit bacteria at lower concentration The MIC of Ag @ cd-mof was 16 μ g / ml and 128 μ g / ml in E After the cyclodextrin unit on the surface of Ag @ cd-mof particles is chemically cross-linked by carbonate bond, a large number of ultra-fine Ag NPs are fixed in the particles to achieve slow-release; then, GS5 oligopeptide is used to modify the cross-linked cd-mof surface (gs5-cl-ag @ cd-mof), to promote the hemostasis function of platelets, enhance the hemostasis effect, promote the adhesion of particles in the wound site, and cooperate with Ag The antibacterial effect of NPs can promote wound healing In the wound healing experiment, compared with other experimental groups, gs5-cl-ag @ cd-mof was the fastest This research achievement was recently published in small (DOI: 10.1002 / small 201901065) in the form of inside front cover cover cover cover The research was completed by Dr shailendra Shakya and he Yaping, Ph.D students from Nepal Professor ruxandra Gref and Dr Li Haiyan participated in the discussion and guidance The research work was supported by the special project of strategic leading science and technology of Chinese Academy of Sciences (xda12050307), the research on key technologies and standards for consistency evaluation of major new drug creation drugs (2018zx09721002-009) and the independent deployment research project of Chinese Academy of Sciences (casimm0120120182001) Ultrafine silver nanoparticles have high antibacterial activity (source: small)