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Drug addiction is a major problem in public health
.
In recent years, physical methods (non-invasive brain stimulation, exercise training) have become an important strategy for drug rehabilitation and good progress has been made
.
Exercising drug rehabilitation is an effective means of judicial drug rehabilitation in China in recent years, and it has formed a large-scale practical application
.
However, the neural mechanism of exercise detoxification has not been fully revealed, which limits the expansion of exercise therapy to a certain extent
.
The team of Academician Su Guohui of the Guangdong-Hong Kong-Macao Central Nervous Regeneration Research Institute of Jinan University and Zhang Zhang’s research group have focused on the theme of "exercise and brain health" in the past ten years.
) Is the representative "peripheral-central" motor factor, discovered the key molecular pathways that chronic aerobic exercise mediates the improvement of neuroplasticity, and formed a relatively complete theoretical system and research basis for the improvement of neurological function by exercise
.
On October 22, 2021, the research team published an article Physical exercise rescues cocaine-evoked synaptic deficits in motor cortex in the journal Molecular Psychiatry, using a mouse model of chronic cocaine exposure to further elucidate the cortical synaptic remodeling of exercise detoxification Mechanism
.
In this study, through the in vivo two-photon imaging technology, it was found that the continuous cocaine exposure caused a significant decrease in the newborn rate of the apical dendritic spine of the L5 pyramidal neurons in the primary motor cortex (M1) of mice, accompanied by the enhancement of excitatory synaptic transmission and synaptic transmission.
Excessive activity of pretouch somatostatin-positive interneurons (SST-IN) eventually leads to an imbalance of local excitation-inhibition homeostasis (E/I balance)
.
These changes participate in the process of animal cognitive behavior impairment (such as the decline of motor learning ability)
.
After drug withdrawal, the research team gave the mice 1 hour of treadmill training per day for 7 consecutive days, and found that it can effectively restore normal dendritic spinogenesis (Figure 1), remodeling synaptic transmission and the balance of excitatory inhibition (Figure 1).
2), and significantly improve the animal's motor learning ability
.
Figure 1 Exercise promotes cortical synaptic remodeling during the withdrawal period of addictive drugs Figure 2 Cortical local excitement-inhibitory microcircuits in motor regulation Changes in molecular signaling pathways have found that exercise can activate the target of rapamycin (mTOR) pathway in the cortex
.
Through pharmacological intervention, DOX-ON-mediated gene expression knockdown means inhibiting the mTOR pathway, or blocking de novo protein synthesis (de novo protein synthesis) and other means can weaken the remodeling of cortical synaptic function caused by exercise
.
These evidences suggest that exercise activates the mTOR pathway in cortical neurons, regulates synaptic activity, increases new dendritic spines, and improves learning ability (Figure 3)
.
Figure 3 The molecular-loop mechanism that exercise enhances cortical synaptic remodeling and promotes drug rehabilitation.
This study reveals the synaptic remodeling mechanism of exercise rehabilitation and drug rehabilitation, and provides more for the development of sports brain science, addiction medicine, physical rehabilitation and other fields Theoretical evidence
.
Accurate measurement of cortical function and neural activity can be used as a new objective evaluation index for the efficacy of sports rehabilitation; auxiliary regulation of cortical function through non-invasive brain stimulation and other neuromodulation techniques is expected to optimize the efficacy of sports rehabilitation and achieve coordinated intervention
.
The project was led by Zhang Li's research team, and the research process was supported by the collaboration of Academician Su Guohui of Jinan University and Professor Yuan Tifei from Shanghai Mental Health Center
.
Cheng Tong, a master's degree graduate of Jinan University, is the first author.
Huang Xiaodan, Hu Xuefei, Wang Siqi, Chen Kai, Wei Ji'an, and Yan Lan also participated in the project
.
Original link: https:// Jinan University's Zhang Li Research Group focused on the regulatory mechanism and intervention strategies of cortical synaptic plasticity, with special attention to the effects of aerobic exercise on affective cognitive impairment Improve effect
.
In recent years, a series of high-level results have been achieved in this field, including: (1) the discovery that mTOR is a key molecular pathway for exercise to improve synaptic plasticity (Sci Adv 2019); (2) the analysis of exercise-activated protein phosphatase PP2A to relieve stress The mechanism of cognitive impairment caused by stimulation (Neurosci Bull 2021); (3) The mechanism of peripheral inflammation in the hepatic encephalopathy model leading to cortical synaptic disorders and learning deficits (Brain Behav Immun 2019)
.
This article is another important achievement made by Zhang Zhang's research group in the field of sports and drug rehabilitation
.
The research team recruits postdoctoral fellows and research assistants for a long time
.
Resume delivery (if you are interested, please send your resume and other materials to): https://jinshuju.
net/f/ZqXwZt or scan the QR code to deliver your resume.
Platemaker: Notes for reprinting on November 11 [Non-original article] The copyright of this article belongs to the author of the article All, personal forwarding and sharing are welcome, reprinting is prohibited without permission, the author has all legal rights, and offenders must be investigated
.
.
In recent years, physical methods (non-invasive brain stimulation, exercise training) have become an important strategy for drug rehabilitation and good progress has been made
.
Exercising drug rehabilitation is an effective means of judicial drug rehabilitation in China in recent years, and it has formed a large-scale practical application
.
However, the neural mechanism of exercise detoxification has not been fully revealed, which limits the expansion of exercise therapy to a certain extent
.
The team of Academician Su Guohui of the Guangdong-Hong Kong-Macao Central Nervous Regeneration Research Institute of Jinan University and Zhang Zhang’s research group have focused on the theme of "exercise and brain health" in the past ten years.
) Is the representative "peripheral-central" motor factor, discovered the key molecular pathways that chronic aerobic exercise mediates the improvement of neuroplasticity, and formed a relatively complete theoretical system and research basis for the improvement of neurological function by exercise
.
On October 22, 2021, the research team published an article Physical exercise rescues cocaine-evoked synaptic deficits in motor cortex in the journal Molecular Psychiatry, using a mouse model of chronic cocaine exposure to further elucidate the cortical synaptic remodeling of exercise detoxification Mechanism
.
In this study, through the in vivo two-photon imaging technology, it was found that the continuous cocaine exposure caused a significant decrease in the newborn rate of the apical dendritic spine of the L5 pyramidal neurons in the primary motor cortex (M1) of mice, accompanied by the enhancement of excitatory synaptic transmission and synaptic transmission.
Excessive activity of pretouch somatostatin-positive interneurons (SST-IN) eventually leads to an imbalance of local excitation-inhibition homeostasis (E/I balance)
.
These changes participate in the process of animal cognitive behavior impairment (such as the decline of motor learning ability)
.
After drug withdrawal, the research team gave the mice 1 hour of treadmill training per day for 7 consecutive days, and found that it can effectively restore normal dendritic spinogenesis (Figure 1), remodeling synaptic transmission and the balance of excitatory inhibition (Figure 1).
2), and significantly improve the animal's motor learning ability
.
Figure 1 Exercise promotes cortical synaptic remodeling during the withdrawal period of addictive drugs Figure 2 Cortical local excitement-inhibitory microcircuits in motor regulation Changes in molecular signaling pathways have found that exercise can activate the target of rapamycin (mTOR) pathway in the cortex
.
Through pharmacological intervention, DOX-ON-mediated gene expression knockdown means inhibiting the mTOR pathway, or blocking de novo protein synthesis (de novo protein synthesis) and other means can weaken the remodeling of cortical synaptic function caused by exercise
.
These evidences suggest that exercise activates the mTOR pathway in cortical neurons, regulates synaptic activity, increases new dendritic spines, and improves learning ability (Figure 3)
.
Figure 3 The molecular-loop mechanism that exercise enhances cortical synaptic remodeling and promotes drug rehabilitation.
This study reveals the synaptic remodeling mechanism of exercise rehabilitation and drug rehabilitation, and provides more for the development of sports brain science, addiction medicine, physical rehabilitation and other fields Theoretical evidence
.
Accurate measurement of cortical function and neural activity can be used as a new objective evaluation index for the efficacy of sports rehabilitation; auxiliary regulation of cortical function through non-invasive brain stimulation and other neuromodulation techniques is expected to optimize the efficacy of sports rehabilitation and achieve coordinated intervention
.
The project was led by Zhang Li's research team, and the research process was supported by the collaboration of Academician Su Guohui of Jinan University and Professor Yuan Tifei from Shanghai Mental Health Center
.
Cheng Tong, a master's degree graduate of Jinan University, is the first author.
Huang Xiaodan, Hu Xuefei, Wang Siqi, Chen Kai, Wei Ji'an, and Yan Lan also participated in the project
.
Original link: https:// Jinan University's Zhang Li Research Group focused on the regulatory mechanism and intervention strategies of cortical synaptic plasticity, with special attention to the effects of aerobic exercise on affective cognitive impairment Improve effect
.
In recent years, a series of high-level results have been achieved in this field, including: (1) the discovery that mTOR is a key molecular pathway for exercise to improve synaptic plasticity (Sci Adv 2019); (2) the analysis of exercise-activated protein phosphatase PP2A to relieve stress The mechanism of cognitive impairment caused by stimulation (Neurosci Bull 2021); (3) The mechanism of peripheral inflammation in the hepatic encephalopathy model leading to cortical synaptic disorders and learning deficits (Brain Behav Immun 2019)
.
This article is another important achievement made by Zhang Zhang's research group in the field of sports and drug rehabilitation
.
The research team recruits postdoctoral fellows and research assistants for a long time
.
Resume delivery (if you are interested, please send your resume and other materials to): https://jinshuju.
net/f/ZqXwZt or scan the QR code to deliver your resume.
Platemaker: Notes for reprinting on November 11 [Non-original article] The copyright of this article belongs to the author of the article All, personal forwarding and sharing are welcome, reprinting is prohibited without permission, the author has all legal rights, and offenders must be investigated
.
