Zhang Zhijun's research team of Suzhou Institute of nanotechnology has made progress in the field of tracking stem cells transplanted in the treatment of pulmonary fibrosis with gold-based CT nano tracer
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Last Update: 2019-11-16
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Source: Internet
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Author: User
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Pulmonary fibrosis is a common progressive and fatal interstitial lung disease, which is characterized by excessive proliferation of fibroblasts and excessive deposition of extracellular matrix, which leads to the destruction of normal lung tissue structure and function Its pathogenesis is not clear, and there is a lack of effective drugs According to the literature, mesenchymal stem cells can be activated in the damaged tissue, and generate basic factors to inhibit fibrosis and apoptosis through paracrine, so as to stimulate the host progenitor cells to repair lung injury However, the location, distribution and survival status of stem cells after transplantation are still unclear Therefore, it is urgent to develop a non-invasive and visual imaging technology to study the fate and distribution of transplanted stem cells in vivo, so as to effectively guide the treatment of pulmonary fibrosis by stem cells According to this, Zhang Zhijun, research team of Suzhou Institute of nanotechnology and nano bionics, Chinese Academy of Sciences, coupled gold nanoparticles with PEG and membrane penetrating peptide (TAT), and constructed a new CT nano tracer (AU @ TAT), which was used to label mesenchymal stem cells, and combined with luciferase reporter gene (rfluc) The transplanted stem cells were traced by CT / bli This work takes advantage of micro CT imaging technology with high penetration depth and high spatial resolution, and with bioluminescence (BLI) The technique has the advantages of high sensitivity and recognition of living cells It can accurately locate the living stem cells in the transplanted body, realize the high sensitivity and real-time tracing of the lung transplantation stem cells in the treatment process, and preliminarily explore the regeneration mechanism of stem cells in the treatment of pulmonary fibrosis These results were recently published online in the international academic journal small (DOI: 10.1002 / small 201904314) Bao Hongying, a master student of the research group, is the first author, and Zhang Zhijun, a researcher, and Huang Jie, an associate researcher, are co correspondents The related work was completed under the support of national key R & D plan "stem cell transformation project" and National Natural Science Foundation.
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