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    Home > Biochemistry News > Biotechnology News > Zhao Shanchao's team published a high-level research paper in "Molecular Cancer"

    Zhao Shanchao's team published a high-level research paper in "Molecular Cancer"

    • Last Update: 2022-01-24
    • Source: Internet
    • Author: User
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    Recently, the research team of Zhao Shanchao from Department of Urology, Department of Urology of Nanfang Hospital/Third Affiliated Hospital of our school published a research paper "Hsa_circ_0003258 promotes prostate cancer metastasis by complexing with IGF2BP3 and sponging miR-653-5p" in the internationally renowned journal "Molecular Cancer"
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    Doctoral student Yu Yuzhong is the first author, and Zhao Shanchao is the last corresponding author


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    In this study, differentially expressed circRNAs were identified by RNA sequencing of prostate cancer clinical samples and found that hsa_circ_0003258 expression was increased in prostate cancer tissues and correlated with advanced TNM stage and ISUP grade
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    hsa_circ_0003258 is able to promote prostate cancer cell metastasis in vitro and in vivo by inducing epithelial-mesenchymal transition (EMT)


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    In conclusion, this study found that the up-regulation of hsa_circ_0003258 drives tumor metastasis through two pathways, the hsa_circ_0003258/miR-653-5p/ARHGAP5 axis and the hsa_circ_0003258/IGF2BP3/HDAC4 axis
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    This provides new potential biomarkers for metastatic risk prediction in prostate cancer and new potential targets for therapy


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