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2021 Nian 8 Yue 2 days, Jin Jin Hospital Task Force and Run Run Shaw Hospital, Zhejiang University, Cao Qian Task Force in cooperation Immunity published online entitled "Multiomic analyses reveal a critical role of selenium in controlling T cell differentiation in Crohn's disease" The research paper analyzed the mechanism by which trace element selenium regulates the differentiation of Th1 cells in CD patients .
Inflammatory bowel disease (IBD ) refers to a group of non-specific chronic gastrointestinal inflammatory diseases of unknown cause, mainly including ulcerative colitis ( UC ), Crohn disease ( Crohn disease, CD).
), its etiology and pathogenesis are not yet fully clear.
The study found disease-specific immune cell subgroups through single-cell sequencing of intestinal biopsy samples from healthy controls and newly diagnosed CD and UC patients
.
Characteristics of differences in the expression of cell populations found metabolic changes related genes, suggesting that metabolic regulation in CD and UC immune response mode has an important role
The research was funded and supported by the Key R&D Program of the Ministry of Science and Technology, the National Natural Science Foundation of China, the Natural Science Foundation of Zhejiang Province, and the Key R&D Program of Zhejiang Province
.
Zhejiang University Shao PhD hospital Huang Lingjie Shaw, Ph.
D.
Institute of Life Sciences, Zhejiang University and Mao Xintao School of Life Science and Technology, Southeast University Associate Professor Li Yi Yuan as co-first author of the paper
Original link: https://
