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Zhejiang University "Nature Communications" published an article: Structural information and activation mechanism of the drug target bradykinin receptor

 Last Update: 2022-03-09
 Source: Internet
 Author: User

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On February 7 ,2022 , the research team of Zhang Haitao from the School of Pharmacy, Zhejiang University published a research paper entitled " Cryo-EM structures of human bradykinin receptor-Gq proteins complexes " in the internationally renowned journal " Nature Communications " .

Type 2 bradykinin receptor ( type 2 bradykinin receptor , B2R ) belongs to G protein-coupled receptors ( GPCR ) and is an important part of the kallikrein-kinin system ( KKS ) .

Both Bradykinin and kallidin are kinin substances in the human body, which are produced by the cleavage of kininogen

Activation mechanism of bradykinin receptor B2R

Binding mode of Gq protein to bradykinin receptor B2R

The first author of this article is Shen Jinkang, a doctoral student at the School of Pharmacy , Zhejiang University, and the corresponding author is Zhang Haitao, a researcher at

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