Zhejiang University Science Advances published a paper: HSPA13 shunts a new mechanism of TNFα signaling

On October 6, 2021 , Xinhua Feng's laboratory published a research paper entitled "HSPA13 Facilitates NF- k B-mediated Transcription and Attenuates Cell Death Responses in TNF aSignaling" online in Science Advances .

Dr.

RIP1 is a key shunt factor for TNF a signal transduction , and its post-translational modifications, including phosphorylation and ubiquitination, regulate its activity

TNF a signaling is an important drug development target in autoimmune diseases and cancer

This work was funded and supported by the National Natural Science Foundation of China's key projects and major research projects, the Zhejiang Provincial Natural Science Foundation and the "Double First Class" special funds .

Legend: Schematic diagram of HSPA13 regulating TNF a signal transduction shunt

After the cytokine TNF a binds to the receptor TNFR1 , the activated TNFR1 recruits a variety of adaptor proteins to quickly assemble to form a complex I anchored to the cell membrane

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