Zheng Xiaofeng's research group from the School of Life Sciences reveals a new mechanism for the regulation of the Warburg effect

Recently, the research group of Professor Zheng Xiaofeng from the School of Life Sciences published a research article entitled " Deubiquitinase OTUB2 exacerbates the progression of colorectal cancer by promoting PKM2 activity and glycolysis " in the journal Oncogene .

The Warburg effect is a hallmark feature of tumor cell metabolism, and abnormal regulation of tumor cell metabolism will significantly affect tumor cell proliferation

This study helps to understand the reason why the deubiquitinase OTUB2 is highly expressed in colorectal cancer patients, reveals its molecular mechanism by regulating tumor cell metabolism and promotes tumor development, and deepens people's understanding of the mechanism of tumor cell metabolism regulation

OTUB2 regulates PKM2 ubiquitination and affects tumor cell metabolism

Yu Shuyu, a doctoral student in Zheng Xiaofeng's research group at Peking University, is the first author of the Oncogene article, and Zheng Xiaofeng is the corresponding author of the article