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    Home > Medical News > Latest Medical News > Zhimeng Pharmaceutical's TLR8 agonist obtains FDA clinical trial approval

    Zhimeng Pharmaceutical's TLR8 agonist obtains FDA clinical trial approval

    • Last Update: 2022-01-11
    • Source: Internet
    • Author: User
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    Source: Guanlan Pharmaceutical

    Recently, Zhimeng Pharmaceutical announced that the US FDA has approved the clinical trial application of its small molecule oral TLR8 agonist CB06-036
    .
    CB06-036 is a drug candidate for the treatment of chronic hepatitis B, independently developed by Zhimeng Pharmaceutical

    .

    As a TLR8 agonist, CB06-036 has shown good selectivity, activity and safety in preclinical studies.
    It can induce cytokines in human peripheral blood mononuclear cells.
    These cytokines can pass through a variety of immune mediators.
    , Activate the anti-virus function

    .
    At the same time, it has also been found to have good liver targeting characteristics

    .
    Based on this license, Zhimeng Medicine is about to start a phase 1 clinical trial in the United States, which will use healthy volunteers as subjects to evaluate the safety and tolerability of CB06-036 after oral ascending doses, and to determine the effectiveness of the drug in the body.
    Research on kinetics and pharmacodynamics

    .

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