Zhou Jiangbing from Yale University collaborates to discover new ways to treat brain tumors

In a new study published in the Journal of Clinical Investigation Insight on June 16, Beijing time, a research team led by Yale University found that the nucleoside transporter ENT2 may provide an unexpected way to bypass Cross the blood-brain barrier (BBB) ​​and enable a cell-penetrating anti-DNA autoantibody to target brain tumors
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The corresponding author of the study, James E.
Hansen, Director of Radiation Oncology, Yale Gamma Knife Center at Yale Smilow Cancer Hospital, said: "These findings are very encouraging because the blood-brain barrier prevents most antibodies from penetrating the central nervous system and limits antibody-based A method for the treatment of brain tumors
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"Deoxymab-1 (DX1) is an unusual cell-penetrating autoantibody that can be localized in the nucleus of living cells, inhibit DNA repair, and respond to cancer cells with defects in DNA damage response (DDR) It has comprehensive lethality
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Researchers have now discovered that the transporter ENT2 promotes the penetration of DX1 into brain endothelial cells and the transport of the blood-brain barrier
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In the efficacy study of mouse models, DX1 crosses the blood-brain barrier to inhibit the brain metastasis of glioblastoma in situ and breast cancer
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Professor Zhou Jiangbing, the co-corresponding author of the study and the Department of Neurosurgery at Yale University School of Medicine, said: “Our data show that in a variety of models, DX1 can cross the blood-brain barrier and inhibit brain tumors.
What impresses us in particular is that DX1 can As a single drug, these results are produced in these difficult-to-treat tumor models
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" Hansen added: "We believe that the ENT2-related mechanism that transports DX1 to tumors through the blood-brain barrier will help provide a variety of new treatments for brain tumors.
Strategy
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In addition to establishing a proof-of-concept for DX1 single-agent use in brain tumor models, we now also recognize that DX1 has the potential to target the connected Cargo molecule to brain tumors, or as a platform for the design of other brain tumor-targeting antibodies, including those based on DX1 Of bispecific antibodies
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"The link to the paper: https://insight.
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