Zhou Jing's team revealed a new mechanobiological mechanism of venous graft restenosis after arterial-vein transplantation

Coronary artery bypass grafting (CABG) is the gold standard for the treatment of patients with complex multivessel and / or left main coronary artery disease [1] .

Mitofusin 2 ( mitofusin 2, MFN2) is an inhibitory molecule of smooth muscle cell proliferation , which can function through mitochondria-dependent and mitochondria-independent regulatory pathways [6,7]

This study found that after the venous graft was implanted in the arterial system, the high mechanical stretch caused by arterial hypertension acting on the venous wall could lead to the transcriptional repression of MFN2 by activating the ROCK/JNK/SP1 signaling pathway in smooth muscle cells ; the deletion of MFN2 On the one hand, by inhibiting the ubiquitination and degradation of PFK1 mediated by E3 ubiquitin ligase TRIM21 , the content of PFK1 and the level of cellular glycolysis can be increased; on the other hand, it can also directly inhibit mitochondrial oxidative phosphorylation .

Zhou Jing's research group is devoted to studying the mechanism of the influence of hemodynamic factors (such as blood flow shear and mechanical stretch, matrix stiffness and topology, etc.

Original link:

https:// Caliskan E, De Souza DR, Boning A, Liakopoulos OJ, Choi YH, Pepper J, Gibson CM, Perrault LP, Wolf RK, Kim KB, Emmert M Y.

[2] Sousa- Uva M, Neumann FJ, Ahlsson A, Alfonso F, Banning AP, Benedetto U, Byrne RA, Collet JP, Falk V, Head SJ, Juni P, Kastrati A, Koller A, Kristensen SD, Niebauer J, Richter DJ, Seferovic PM, Sibbing D, Stefanini G G , Windecker S, Yadav R, Zembala MO, Group ESCS D.

[3] Li Y, Liu S, Zhang Z, Xu Q, Xie F, Wang J, Ping S, Li C, Wang Z, Zhang M, Huang J, Chen D, Hu L, Li C.

[4] Li F, Guo WY, Li WJ, Zhang DX, Lv AL, Luan RH, Liu B, Wang H C.

[5] Wernig F, Mayr M, Xu Q.

[6] Ryan J, Dasgupta A, Huston J, Chen KH, Archer S L.

[7] Fang X, Chen X, Zhong G, Chen Q, Hu C.

[8] Li T, Han J, Jia L, Hu X, Chen L, Wang Y.

(Peking University School of Basic Medicine )