Zhou Yu/Fu Xiangdong Collaborated to Reveal a New Model of Progressive Processing of RNA Variable Polyadenylation

On January 10, 2022, Professor Zhou Yu's research group from the School of Life Sciences of Wuhan University, the State Key Laboratory of Virology, and Professor Fu Xiangdong from the University of California, San Diego collaborated on an online publication entitled "Alternative polyadenylation by sequential activation of distal and proximal PolyA sites" research paper

In the process of studying the problem of RNA nuclear retention, the authors found that incompletely spliced ​​polyA+ RNAs can be retained in the chromatin or nuclear matrix, and they also observed that many genes select distal polyA sites to produce long 3'UTR transcripts also Retained in chromatin or nuclear matrix

To gain further direct evidence, the authors consider that in this two-step processing model, the long 3'UTR transcript should be an intermediate in the processing of the short 3'UTR transcript, and its degradation should also result in the short 3'UTR transcript.

Figure 1.

Based on the above evidence, the authors propose a new mode of APA progressive processing "sequential polyadenylation" (Fig.

Professor Zhou Yu and Professor Fu Xiangdong are the co-corresponding authors of the research paper, postdoctoral fellows Tang Peng and Dr.

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