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    Home > Biochemistry News > Biotechnology News > Zhu Xueliang's group reveals the molecular mechanism of central microtubule formation in mammalian cilia

    Zhu Xueliang's group reveals the molecular mechanism of central microtubule formation in mammalian cilia

    • Last Update: 2021-10-22
    • Source: Internet
    • Author: User
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    Motile cilia (motile cilia) is a hair-like organelle protruding from the cell surface, composed of basal body, axoneme and ciliary membrane


    The axon filaments of the kinesis are formed by the peripheral microtubules formed by 9 groups of microtubule duplexes and two central microtubules


    Through the expression profile analysis and ultra-high-resolution microscopic observation of the differentiation process of mouse tracheal epithelial polyciliated cells, the researchers found that Wdr47 is a mammalian motility ciliary central tubule protein (Figure A), and Wdr47 knocks out the brain ventricles of mice The dynamic cilia changes from swinging to rotating mode


    Researcher Zhu Xueliang and Researcher Yan Xiumin (currently researcher of the Environmental and Child Health Key Laboratory of Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine) from the Center of Molecular Cell Excellence are the co-corresponding authors of the paper.


    Article link: https:// 

    (A) Wdr47 is a central microtubule-associated protein; (B) Wdr47 knocked out kinesiocilium completely lacks central microtubules; (C) Overexpression of Camsap can partially restore the formation of central microtubules of Wdr47-/- cilia, but also Resulting in the formation of >2 central microtubules; (D) A schematic diagram of the formation of central microtubules in the motile cilia


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