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Science: How do glass frogs become transparent?
Time of Update: 2023-02-03
This work could lead to new research related to blood clots, as glass frogs pack and transport about 90 percent of their red blood cells to the liver each day, but somehow avoid the production of blood clots.
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The research of Professor Qian Feng's team of Shanghai Jiaotong University revealed a new mechanism of pneumonia caused by methicillus-resistant Staphylococcus aureus
Time of Update: 2023-02-03
On January 2, 2023, Professor Qian Feng's research group of the School of Pharmacy of Shanghai Jiao Tong University published a report entitled Staphylococcal virulence factor HlgB targets the endoplasmic-reticulum-resident E3 ubiquitin ligase AMFR to the top international academic journal Nature Microbiology (IF=30.
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New Spaceomics Techniques: Exploring the Early Stages of Disease
Time of Update: 2023-02-03
Most illnesses are initially asymptomatic, and the affected person usually still feels good — symptoms haven't yet appeared, or are still too mild to be aware of. However, changes have taken place in
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Zhong Qing/Wang Weiwei, School of Basic Medical Sciences, et al. reported a new spray-type contrast agent that rapidly identifies tumor boundaries
Time of Update: 2023-02-03
During surgery, S-4-NP can be directly sprayed with the isolated tumor tissue section, and the tumor tissue can be clearly identified within 3 minutes through near-infrared imaging, thereby helping clinical surgeons quickly distinguish the boundary between tumor tissue and normal tissue, and judge the surgical margin (see Figure 3 for the complete imaging video).
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Changes in the intrinsic behavior of neurons
Time of Update: 2023-02-03
Researchers from Harvard's John Paulson School of Engineering and Applied Science (SEAS) and MIT have developed a new method to target diseased neurons in the brain and use light to alter their long-term behavior, paving the way for potential new treatments for neurological disorders such as epilepsy and autism.
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The main pathogen taxa of fungal meningitis are endemic to the regulatory basis and evolutionary pathways of the main pathogen taxa
Time of Update: 2023-02-03
On December 24, 2022, the research team of Wang Linqi, State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, published an article entitled "Regulatory basis for reproductive flexibility in a meningitis-causing fungal pathogen" in Nature Communications.
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PNAS: Adjacent cell labeling technology based on membrane-permeable fluorescent proteins
Time of Update: 2023-02-03
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Chen Saijuan's team's latest research: the proportion of severe cases in hospitalized patients with the new crown is about 3%, and the Spring Festival will accelerate the wave of infection, and vulnerable groups need to be protected
Time of Update: 2023-02-03
To assess the proportion of severe/critical cases among symptomatic hospitalized patients, the research team carefully examined 5,706 symptomatic patients admitted to Shanghai Public Health Clinical Center between September 1 and December 26, 2022, and divided them into 4 groups based on symptom severity and past medical history.
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Nature Cancer: Triple immunotherapy holds promise for treating pancreatic cancer
Time of Update: 2023-02-03
1038/s43018-022-00500-z Researchers at the University of Texas MD Anderson Cancer Center have discovered a novel pancreatic cancer immunotherapy combination that targets T cell checkpoints and myeloid suppressor cells, successfully reprogrammed the tumor immune microenvironment (TIME), and significantly improved anti-tumor responses in pancreatic cancer models.
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Brain metastases in melanoma patients, deciphering important molecular mechanisms
Time of Update: 2023-02-03
Different cell states determine the progression of the diseaseThe study's last author, Torben Redmer from the Institute of Medical Biochemistry and Pathology in Vetmeduni, summed up the main findings: "Our study provides evidence that MBMs can be divided into at least two subgroups.
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Use the sword of biological network big data to solve the mystery of corn genetics
Time of Update: 2023-02-03
Inheritance and innovation kicked off the era of maize multi-dimensional network map On December 30, 2022, the journal Nature and Genetics published the collaborative research paper "A multi-omics in
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JAMA sub-journal: Xu Ruihua/Qiu Miaozhen team of Sun Yat-sen University reveals for the first time the germline variation characteristics of patients with hereditary diffuse gastric cancer in China!
Time of Update: 2023-02-03
Subsequently, Xu Ruihua's team compared the somatic variation burden of Chinese HDGC patients and TCGA sporadic diffuse gastric adenocarcinoma (D-STAD) patients, and found that the frequency of gene mutations in the two cohorts was significantly correlated (R=0.
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Chinese scholars have made progress in remodeling antibody characteristics in immunotherapy
Time of Update: 2023-02-03
Figure Immune checkpoint blocking therapy remodeling antibody characteristics induces tumor immune evasion With the funding of the National Natural Science Foundation of China (grant numbers: 82025016, 31830025 and 81901585), Professor Kwong Dongming's team of Sun Yat-sen University has made progress in remodeling antibody characteristics in immunotherapy 。 The findings are based on "Immune checkpoint therapy-elicited sialylation of IgG antibodies impairs antitumorigenic type I interferon responses in hepatocellular.
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Nature Genetics international large-scale research has revealed dozens of new genes linked to heart disease
Time of Update: 2023-02-03
Most of the new genomic loci were associated with very small changes in CAD risk, suggesting that few, if any, common genetic variants that had a significant impact on CAD risk by studying people of predominantly European ancestry were yet to be discovered, and to improve their discovery power, the researchers combined their large dataset with data from tens of thousands of individuals of East Asian descent from the Japan Biobank, including 29,000 CAD patients.
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MIT research subverts cognition: "Memory" may not be in neurons, but between synapses!
Time of Update: 2023-02-03
The researchers correlated the output (activity at the top and decoder precision at the bottom) with real neural data (left column) and several working memory models (right column). Most similar to t
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To infect the brain, the fungus learns to make itself smaller in guano!
Time of Update: 2023-02-03
Figure 3 Macrophage recognition of mannose helps small ex vivo cells to be uptaken by organs (Source: [1])03 One side of soil and water culture and one side of "bacteria": the pigeon fecal environment enhances the organ entry ability of Cryptococcus neoformansThe results of the venous transmission model showed that cell size was not the only factor affecting the rate of diffusion, and that the culture conditions of the fungus also greatly influenced the distribution in the organ.
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New bacterial therapies for lung cancer are released
Time of Update: 2023-02-03
To test the hypothesis, the researchers blocked these pathways with current anti-cancer drugs and showed that combining the drugs with bacterial toxins was more effective at eliminating lung cancer cells.
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Flu or cold? A home smart device can help you
Time of Update: 2023-02-03
"Our microresonators are about 100 times better than previous resonators used for longwave infrared spectroscopy," Dingding Ren said.
"Our microresonators are about 100 times better than previous resonators used for longwave infrared spectroscopy," Dingding Ren said.
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Japanese scientists expand stockpile of drugs to fight COVID-19
Time of Update: 2023-02-03
While testing a group of compounds known to have inhibitory activity against the 2002 SARS-CoV virus, the research team identified a compound called 5h, which showed activity to inhibit SARS-CoV-2 Mpro, but was inefficient and unstable.
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For the first time, human brain organoids were implanted into the mouse cortex, and they responded to visual stimuli...
Time of Update: 2023-02-03
The implanted organoids respond to visual stimuli in the same way as surrounding tissues, and thanks to an innovative experimental setup that combines a transparent graphene microelectrode array and two-photon imaging, the researchers were able to observe this phenomenon in real time over several months.