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New progress has been made in the research on the anti-rust mechanism of coffee
Time of Update: 2023-02-03
Large-grain coffee transcript annotation (A) and single-copy gene-constructed coffee genus maximum likelihood tree (B) Coffee rust caused by Hemileia vastatrix is a devastating disease that has become an important crop protection problem restricting coffee production.
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Chinese scholars have made progress in the research of distributed source coding
Time of Update: 2023-02-03
Fig. 1 Schematic diagram of the comparison of traditional source coding and distributed source coding principles: (A) traditional source coding (symmetrical); (B) distributed source coding (symmetric
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New progress has been made in the study of leucine-regulated autophagy
Time of Update: 2023-02-03
Recently, the research results of Professor Yan Xianghua's team from the National Key Laboratory of Agricultural Microbiology, Hubei Hongshan Laboratory and the Frontier Science Center for Animal Bre
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A cancer vaccine that kills two birds with one stone: prevents + kills brain cancer
Time of Update: 2023-02-03
“Bifunctional cancer cell-based vaccine concomitantly drives direct tumor killing and antitumor immunity” Science Translational Medicine Scientists have developed a dual-function therapeutic strategy that converts live tumor cells into therapeutic drugs.
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Chinese scholars have made progress in the latitude of the lunar surface and the formation of solar wind water
Time of Update: 2023-02-03
Fig. 1 Hydrogen content depth profile of Chang'e-5 lunar soil particles and their space regolith layer thickness Fig. 2 Numerical simulation of hydrogen content depth profile in silicate glass and mi
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Proof-of-concept and drug candidate discovery of CHK1/FLT3 dual-targeted inhibitors
Time of Update: 2023-02-03
Based on the synergistic potential of CHK1 inhibitors and FLT3 inhibitors in combination with FLT3 inhibitors, this study proposed the concept of innovative drug development with dual targeted inhibition of CHK1/FLT3, and identified TLX83, a preclinical candidate molecule for dual targeted inhibition of FLT3/CHK1, which can not only strongly inhibit the growth of a variety of FLT3-acquired mutant cells, but also fight cytokine-induced adaptive resistance.
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A previously unknown cellular component: a new cellular component that is important for the sense of smell
Time of Update: 2023-02-03
This discovery was made possible by devvendra Kumar Maurya using a new technique called correlation microscopy, which combines electron microscopy and confocal microscopy so that the internal structure of cells and the location of different proteins can be imagedSource: Mattias PetterssonResearchers at Umeå University in Sweden have discovered a previously unknown cellular component, an organelle, in the neurons we use to sense odors.
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Progress has been made in the application research on desertification prevention and ecological restoration of bentonite, where Xinjiang's habitat is located
Time of Update: 2023-02-03
cm-2Bentonite is a kind of natural mineral material with rich reserves, good environmental protection, the use of desertification prevention and improvement of aeolian sand, the cost is lower than the traditional mechanical windproof and sand fixation measures (1000~5000 $/hm2), and has great application potential in wind and sand disaster management and ecological restoration.
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3 papers of Professor Fang Chihua's team were selected as "F5000-Top Academic Papers of China's Fine Science and Technology Journals"
Time of Update: 2023-02-03
He led the team to establish a theoretical system of three-dimensional visualization and digital intelligent diagnosis and treatment of primary liver cancer, which was used to guide the practice of clinical precision diagnosis and treatment.
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Technology! Chinese scholars bring new expansion microscopy techniques
Time of Update: 2023-02-03
"We overcame some of the long-term challenges of expansion microscopy," says Yongxin Zhao, "and one of Magnify's main selling points is the general strategy of preserving tissue biomolecules, including proteins, nuclear fragments, and carbohydrates, within the expanded sample.
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New progress has been made in the study of the basic regulation and evolutionary pathways of the specific reproductive patterns of the main pathogen taxa of fungal meningitis
Time of Update: 2023-02-03
The research team of Wang Linqi, State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, published an article entitled "Regulatory basis for reproductive flexibility in a meningitis-causing fungal pathogen" in Nature Communications.
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De novo synthetic virus RdRP initiation-extension conversion mechanism
Time of Update: 2023-02-03
Nucleic acid polymerase is a key protein machine for nucleic acid biosynthesis and plays a central role in important processes such as replication, transcription, and reverse transcription. The proce
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New bacterial therapies for lung cancer are released
Time of Update: 2023-02-03
To test the hypothesis, the researchers blocked these pathways with current anti-cancer drugs and showed that combining the drugs with bacterial toxins was more effective at eliminating lung cancer cells.
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PNAS: Adjacent cell labeling technology based on membrane-permeable fluorescent proteins
Time of Update: 2023-02-03
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Danger: Disruption of smell and viral inflammation are associated with accelerated onset of Alzheimer's disease
Time of Update: 2023-02-03
According to a new study by researchers at the University of Colorado's Ann Schutz School of Medicine, viruses may accelerate the onset of Alzheimer's disease by triggering inflammation and disrupting connections between the olfactory system that controls smell and parts of the brain related to memory and learning.
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"PNAS" artificial retinal cells successfully connected to the eye! Unlock a host of new treatments for eye diseases
Time of Update: 2023-02-03
” David Gamm in his labAccording to a new study, retinal cells grown from stem cells can reach out to connect with neighbors, completing a "handshake," which could indicate that the cells are ready for trials in patients with degenerative eye disease.
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Zheng Lemin's team discovered a new mechanism by which putrescine in smooth muscle cells promotes the development of abdominal aortic aneurysm
Time of Update: 2023-02-03
202 2 February 25 Zheng Lemin Group, Institute of Cardiovascular Research, School of Basic Medical Sciences The team published an online publication entitled "GasderminD deficiency in vascular smooth muscle cellsameliorates" in the internationally renowned journal Advanced Science Abdominal aortic aneurysm through reducing putrescine synthesis" paper reports that GSDMD can be accessed in aortic smooth muscle cells Promoting putrescine synthesis and aggravating the development of abdominal aortic aneurysm.
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The Lancet Microbe: A simple nasal swab can provide early warning of emerging viruses
Time of Update: 2023-02-03
Nasal host response-based screening for undiagnosed respiratory viruses: a pathogen surveillance and detection study As the COVID-19 pandemic has shown, potentially dangerous new viruses can begin to circulate among populations before they are detected by global public health surveillance systems.
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Nature Genetics international large-scale research has revealed dozens of new genes linked to heart disease
Time of Update: 2023-02-03
Most of the new genomic loci were associated with very small changes in CAD risk, suggesting that few, if any, common genetic variants that had a significant impact on CAD risk by studying people of predominantly European ancestry were yet to be discovered, and to improve their discovery power, the researchers combined their large dataset with data from tens of thousands of individuals of East Asian descent from the Japan Biobank, including 29,000 CAD patients.
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Chinese scholars have made progress in the research of addiction memory mechanism
Time of Update: 2023-02-03
Figure Addiction cues regulate the dynamic reshaping mechanism of synaptic memory in addiction With the support of the National Natural Science Foundation of China (grant number: 81822017, 82101565), the team of Professor Yuan Yifei of the Shanghai Mental Health Center (National Center for Mental Illness) made progress in the study of the mechanism of addictive memory, and the research results were based on "Retrieval-extinction of drug memory requires AMPA receptor.
