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Nat Metab Huang Hai/Allan Tsung/Deng Meihong and others reveal the mechanism by which preoperative exercise induces Kupffer cell anti-inflammatory immunity after training to reduce liver damage
Time of Update: 2021-08-12
On June 14, 2021, the research team of Huang Hai/Allan Tsung/Deng Meihong of Ohio State University published a research paper entitled Preoperative exercise therapy triggers anti-inflammatory trained immunity of Kupffer cells through metabolic reprogramming in Nature Metabolism.
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What indicators should be paid attention to for psoriatic arthritis?
Time of Update: 2021-08-11
According to the results of the study, it is currently recommended: Disease activity and the impact caused by the disease both require attention and should be tested separately; Psoriasis and Psoriatic Arthritis Research Evaluation Group (GRAPPA) recommends that they are used in clinical trials PASDAS is used as a composite index; minimum disease activity (MDA) is used as the treatment target .
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Nature's Hongbo Chi team reveals that phosphatidylethanolamine metabolism regulates Tfh cell differentiation and humoral immune response
Time of Update: 2021-08-11
Next, the researchers found through transcriptome analysis that Pcyt2 deletion does not affect the early transcriptional programming of Tfh cells mediated by Bcl6, but significantly affects the expression of CXCR5.
The deletion of Pcyt2 gene in activated T cells impairs the differentiation of Tfh cells, which in turn affects the humoral immune response .
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Affecting 300 million Chinese people, it has been confirmed that allergic rhinitis makes people stupid!
Time of Update: 2021-08-11
13328 study included 43 children (8-17 years of age) with grass pollen allergic rhinitis who had unsatisfactory medications in the previous season (antihistamine and nasal steroids were given daily) .
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Systemic Lupus Erythematosus Expert Consensus, General Principles and Recommendations for Treatment of Lupus Nephritis Quick Guide Consensus
Time of Update: 2021-08-11
Mycophenolate mofetil or cyclophosphamide (conventional dose pulse therapy), combined with medium-dose glucocorticoids, is recommended for the induction therapy of active lupus nephritis .
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SciencetRNA's umbrella to avoid excessive stress of T cell immunity
Time of Update: 2021-08-11
Written | Sister Xian, when exposed to external antigens, T cells are rapidly activated, and their transition from a resting state to a proliferating state requires tremendous changes in cell metabol
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Nature: Chi Hongbo's team discovered a new pathway to regulate humoral immune response
Time of Update: 2021-08-11
In summary, this study identified a new pathway regulating the differentiation of TFH cells-CDP-ethanolamine pathway; it clarified that de novo PE synthesis signals determine the function of TFH cells and the strength of humoral immune response by regulating the location and stability of the chemokine receptor CXCR5 ; Reveal the importance of metabolic pathways and post-transcriptional regulation on the differentiation and fate of effector T cells .
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Is benzbromarone still the first-line drug for lowering uric acid?
Time of Update: 2021-08-11
However, the "Guidelines for the Rational Use of Gout (2021)" believe that uric acid excretion drugs are not recommended for first-line treatment, and are contraindicated in patients with CKD ≥3 stage or patients at high risk of kidney stones, although Asian people are due to cytochrome P450.
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Symbiotic bacteria "vaccine" can prepare immune cells for relative bacteria that cause meningitis|《Science · Translational Medicine》
Time of Update: 2021-08-11
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However, the immune system is usually tolerant to commensal bacteria, and it has been difficult to deliver bacterial antigens through genetic engineering of Neisseria lactose .
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Research on Nature by Chi Hongbo's Research Group: Revealing the Key Pathway to Regulate the Function of the Immune System
Time of Update: 2021-08-10
In this study, Professor Chi Hongbo and colleagues used CRISPR-Cas9 technology to screen in mice to find out which key enzymes in the metabolic control pathway will affect the function of Tfh cells after the deletion .
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Nat Commun Yang Keli/Zhao Jijun collaborated to discover a new mechanism for RNA endonuclease to regulate skin inflammation
Time of Update: 2021-08-10
The research paper reported that the RNA endonuclease MCPIP3 promotes the molecular mechanism of psoriatic skin inflammation by regulating the IL-6 and TNF secreted by plasmacytoid dendritic cells (pDCs) and macrophages .
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Discuss hot spots and trends, what are the research results of primary Sjogren’s syndrome in 2021?
Time of Update: 2021-08-10
The results showed that compared with hydroxychloroquine (HCQ) + glucocorticoid (GC), IGU + HCQ + GC combined treatment significantly improved the clinical symptoms of pSS patients, including inflammatory indicators [ESR (ESR), immunoglobulin G ( IgG), rheumatoid factor (RF) levels], platelet count (PLT), salivary gland and lacrimal gland secretion function, and disease activity scores (ESSPRI and ESSDAI) (Figure 3), the treatment efficiency is also higher (P<0.
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"Cell": Bifidobacterium, you are awesome!
Time of Update: 2021-08-10
They found that the human milk oligosaccharides (HMOs) metabolism gene expressed by bifidobacteria activated the tryptophan metabolism pathway and increased the metabolite of indole-3-lactic acid, thereby promoting the anti-inflammatory cytokine interleukin 27 (IL -27), the expression of interferon beta (IFN-β), and induce T cells to secrete the regulatory factor galectin-1, thereby maintaining the homeostasis of the intestinal and peripheral immune system, and inhibiting the occurrence of excessive immune responses .
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Sci Immuno Zang Xingxing team discovers new immune checkpoint pathways and new tumor treatment methods
Time of Update: 2021-08-10
On July 9, 2021, Professor Zang Xingxing’s team published a paper KIR3DL3-HHLA2 is a human immunosuppressive pathway and a cancer therapeutic target in Science Immunology, revealing that KIR3DL3 is the second but immunosuppressive receptor of HHLA2, and further Prove that blocking this newly discovered immune checkpoint pathway can inhibit the growth of human tumors .
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Scientists discover the "small signal" that the new crown vaccine works
Time of Update: 2021-08-09
For example, the basis for judging whether a new dosage form of influenza vaccine is effective is usually based on whether it can trigger a sufficiently strong antibody response against the viral protein in a small number of people, rather than by observing whether the infection rate has decreased through large-scale experiments .
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5 practical strategies to teach you to better treat spondyloarthritis!
Time of Update: 2021-08-09
Figure 2 The results of the study This will talk about our second strategy-Strategy 2: The use of "advanced new drugs" biologics/small molecule targeted disease-improving anti-rheumatic drugs (b/tsDMARDs) and other new drugs have come out greatly Improved the clinical treatment of SpA and provided patients with more choices .
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Can I start an immune response by seeing a sick partner?
Time of Update: 2021-08-09
Since all healthy canaries can smell and hear the scents and sounds of the diseased group, the researchers speculate that it is the vision that activates the immune system of these birds .
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Is dry mouth and eyes a disease?
Time of Update: 2021-08-09
It should be noted that anti-SSA antibodies are closely related to certain specific clinical manifestations of autoimmune diseases, such as photosensitive skin rash, hypergammaglobulinemia purpura, neonatal lupus syndrome, and congenital heart block (CHB) and so on .
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Hidden killer-new progress in diagnosis and treatment of macrophage activation syndrome (MAS)
Time of Update: 2021-08-09
The results of the study confirmed that the use of Emapalumab in sJIA-MAS patients who have previously received treatment can quickly and effectively neutralize IFN-γ, and the plasma CXCL 9 level significantly decreases during the treatment period (Figure 1) .
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Professor Li Xiaofeng: New exploration in the treatment of AID, combining biological agents with non-drug therapy on the basis of conventional treatment
Time of Update: 2021-08-08
Professor Li Xiaofeng pointed out that according to the type of immune response of different diseases, biological agents with different mechanisms of action should be selected for highly matched treatment .