-
JAHA: Serum growth differentiation factor 15 levels are associated with post-ischemic stroke depression
Time of Update: 2022-01-08
Recently, the heart blood vessels published a research article on the disease areas authoritative magazine JAHA, the purpose of this study was to investigate the correlation between serum levels of GDF 15-PSD patients with ischemic stroke .
-
Professor Yang Qingwu, JAMA Sub-Journal: The endovascular treatment of patients with acute basilar artery occlusion has significantly improved the good outcome!
Time of Update: 2022-01-08
90-day mRS scoreIn patients receiving EVT, the baseline NIHSS score increased and the probability of good functional outcome decreased (for every 1 point increase in the score, OR=.
-
Pfizer's DMD gene therapy fordadistrogene movaparvovec was shelved by the FDA after the patient died
Time of Update: 2022-01-08
After the death of one patient in the Phase Ib study, the FDA shelved the clinical trial of Pfizer's Duchenne Muscular Dystrophy (DMD) drug candidate fordadistrogene movaparvovec .
com/story/5466389 https://firstwordpharma.
com/story/5466389 https://firstwordpharma.
-
The guide recommends the interpretation of the "Experts Consensus on Brain Protection after Cardiac Arrest in China in 2020"-neurological evaluation
Time of Update: 2022-01-08
Please scan the QR code to download the APP directly Download link: Metz Medicine APP Tip: 78% of users have downloaded Metz Medicine APP , which is more convenient to read and communicate.
-
Stroke: Time is the brain: Stroke, the shorter the hospital admission-thrombolysis time, the prognosis is significantly improved
Time of Update: 2022-01-08
They evaluated the door-to-needle (DTN) time and clinical outcome of patients with acute ischemic stroke who received TPA before and after the start of two consecutive national quality improvement initiatives .
-
Neurology: Dual-energy CT features of high-density subarachnoid space after thrombus removal in acute stroke—diffuse mode is associated with poor clinical prognosis
Time of Update: 2022-01-07
This study provides Class II evidence that in patients with proximal carotid artery occlusion who received mechanical thrombectomy, diffuse subarachnoid high density at 8 hours after intervention was associated with poorer clinical outcomes 90 days later .
-
JAMA Neurol: Drug-eluting stents can significantly reduce the risk of intrastent stenosis and stroke recurrence in patients with high-grade ICAS!
Time of Update: 2022-01-07
In order to study whether DES can reduce the risk of ISR and stroke recurrence in symptomatic high-grade ICAS patients , experts from the Department of Neurology, Tiantan Hospital, Capital Medical University of China, carried out related research, and the results were published in JAMA Neurology .
-
Neurology: A powerful biomarker for stroke prognosis-low brown-yellow outer mitochondrial DNA copy number (mtDNA-CN) may be related to poor baseline severity and prognosis after 1 month!
Time of Update: 2022-01-07
This study provides Class II evidence that low-brown-yellow coat mtDNA-CN (>1 standard deviation) in patients with ischemic or hemorrhagic stroke is associated with poor baseline severity and 1-month prognosis .
-
The young guy suddenly "dementia", again this common medicine!
Time of Update: 2022-01-05
In fact, regarding metronidazole-induced encephalopathy, "Medical Neurology Channel" has reported several cases: the patient's sudden speech is slurred, gait wobbly.
Combined with the patient’s medical history, clinical symptoms, cranial MRI findings, and symptoms significantly improved after stopping metronidazole, the patient was diagnosed with Metronidazole-Induced Encephalopathy (MIE) .
-
How to diagnose and treat transient ischemic attack in the early stage depends on the Chinese guidelines!
Time of Update: 2022-01-05
Within 2 to 7 days after the onset of TIA is the high-risk period of stroke, optimize the allocation of medical resources, and establish emergency medical care based on the ABCD2 score (Table 1) stratification and imaging Mode, start TIA assessment and secondary prevention as soon as possible .
-
Express significantly improved the symptoms of exercise and drowsiness in patients with Parkinson's disease, and the new compound preparation reached the key phase 3 clinical endpoint
Time of Update: 2022-01-05
In addition, P2B001, compared with the marketed pramipexole sustained-release therapy, has a similar curative effect, significantly reducing the symptoms of daytime sleepiness in patients, and is accompanied by superior safety .
-
A 10-year-old boy with developmental delay + mental abnormality, this case is said to be undiagnosed by 60% of doctors!
Time of Update: 2022-01-04
Viral encephalitis is manifested as a high signal on the T2 image, involving the deep gray matter and white matter of the brain, including the cerebellum and brainstem .
-
Nature Human cortex precursor cells can produce excitatory and inhibitory neurons
Time of Update: 2022-01-03
Research on neurodevelopment in rodents suggests that the two main cortical neurons-glutamatergic excitatory neurons and GABA inhibitory interneurons are produced by two different precursor cells [1 -2] .
-
Express to further test the Aduhelm effect, Bojian plans to start confirmatory clinical trials
Time of Update: 2022-01-01
▎Editor of WuXi AppTec content team On December 16, 2021, Biogen and Eisai announced that they are expected to start a large confirmatory clinical trial in May next year to further evaluate Alzheimer’s The efficacy of monoclonal antibody therapy Aduhelm (aducanumab) for disease (AD) .
-
The risk of dementia is hidden in the heart rate!
Time of Update: 2022-01-01
A recent study published in the journal Alzheimer's & Dementia[3] found that among elderly people 60 years of age and older, the resting heart rate ≥80 beats per minute (bpm) is between 60-69 bpm.
-
Which medicine should be used for mild and moderately severe "herpes zoster postherpetic neuralgia"?
Time of Update: 2021-12-31
Professor Wang Yu mentioned that timely and effective antiviral treatments, especially those administered within 72 hours of the appearance of the rash, can prevent PHN .
-
Nature: Break the traditional cognition!
Time of Update: 2021-12-31
Nowakowski, Department of Anatomy, University of California, discovered that by developing a molecular barcode tool to track the differentiation of radial glial cells, it was found that human cortical progenitor cells can differentiate into inhibitory neurons .
-
Treat rare diseases!
Time of Update: 2021-12-31
December 18, 2021/MedClub News/--On December 16, 2021, gene therapy company uniQure announced its ongoing Phase I/II clinical trial of AMT-130 for the treatment of Huntington’s disease, recruiting Preliminary observations of the first four patients in the low-dose cohort .
-
The middle-aged man has intermittent convulsions, difficulty walking, dementia...don't miss the cause!
Time of Update: 2021-12-31
About 80% of patients have a family history, all of which are maternal inheritance, mitochondrial dysfunction, insufficient ATP production, and enhanced tissue anaerobic metabolism; ②Clinical manifestations are muscle Clonus, epilepsy, ataxia, dementia, limb weakness, exercise intolerance; ③Laboratory examination of blood gas lactic acid levels increased, and electromyography showed myogenic or neurogenic damage .
-
Nat Neurosci TREM2 new ligand!
Time of Update: 2021-12-31
To further explore the mechanism, the team's research members found that the lack of TREM2 reduced the ability of mouse microglia to engulf and clear pathological TDP-43 (Figure 1), which in turn exacerbated motor neuron death .
