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Novartis DRAGON study yielded positive results, confirming the effectiveness and safety of Erenumab in preventing chronic migraine in adults
Time of Update: 2021-10-21
The DRAGON study has confirmed that Erenumab can significantly reduce the number of migraine days per month for the main chronic migraine population in China (MMD), the safety tolerance is similar to placebo .
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Nature breakthrough!
Time of Update: 2021-10-21
In 2020, the Harvard Medical School Professor Ma Qiufu’s team published in Neuron’s research results, revealing that low-intensity acupuncture to stimulate acupoints on the hind limbs of mice (such as Zusanli ST36) can activate the vagus nerve-adrenal anti-inflammatory pathway, while acupuncture stimulates acupuncture points on the abdomen (such as ST36).
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Neuron Mao Dun et al. reveal the spatial representation characteristics of the hippocampus of freely moving macaques
Time of Update: 2021-10-21
Traditional analysis methods have shown that neuronal activity in the hippocampus of rhesus monkeys presents selective specific firing activities (ie tuning characteristics) for a variety of spatial information, including horizontal position, horizontal head orientation, translational speed, etc.
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Oxford scientists discovered: laxative can also pass memory, this drug may create the "most powerful brain"
Time of Update: 2021-10-21
In this experiment, compared with the placebo group, the procapride group had a significantly increased response to familiar images in the right corner gyrus .
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The results of the Phase III study of FcRn antagonists are gratifying, and patients with systemic myasthenia gravis usher in a new gospel!
Time of Update: 2021-10-21
In June this year, the international authoritative medical journal "The Lancet Neurology" published the results of a phase III clinical study of neonatal Fc receptor (FcRn) antagonist efgartigimod, showing that it has a good effect on the treatment of adult systemic MG (gMG) And safety, which is of great significance to patients .
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After a lapse of 11 years, the European Society of Neurology/Peripheral Neurology has updated its guidelines for the diagnosis and treatment of chronic inflammatory demyelinating polyneuropathy!
Time of Update: 2021-10-21
➤For patients suspected of typical CIDP, because they meet the clinical criteria but do not meet the minimum electrophysiological diagnostic criteria, if they are objectively improved after receiving IVIg, corticosteroids or plasma exchange treatment, and if there is at least one additional support standard, they can Diagnosed as possible typical CIDP .
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Express delivery of more than 70% of patients without recurrence within 4 years, and the new drug for multiple sclerosis has a positive long-term effect
Time of Update: 2021-10-21
▎Bristol-Myers Squibb (BMS), editor of WuXi AppTec's content team, announced today that the S1P receptor modulator Zeposia (ozanimod) has achieved positive results in a phase 3 clinical extension trial for the treatment of patients with relapsing multiple sclerosis (MS) .
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5 new types of anti-epileptic drugs, one article to master!
Time of Update: 2021-10-21
Randomized double-blind clinical controlled trial: Included in 6 countries, 38 centers, 199 patients with confirmed Dravet [baseline seizure frequency more than 4 times comprehensive Tonic-clonic seizures (GTCS)/4 weeks, monotherapy failure]; 10mg and 20mg/kg/d group cannabidiol oral add-on treatment, similar to the reduction of seizure frequency, the 10mg group is better than the 20mg group in safety and tolerability ; The addition of cannabidiol exceeds 10mg/kg/d, and individualized effectiveness and safety should be weighed .
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"The prosperous husband and the poor, the happy extreme is the sad"-the role of the hypothalamus in food rewards and drug rewards
Time of Update: 2021-10-21
For food and entertainment activities, they are somewhere between natural rewards and drug rewards, but as pressure increases and time passes, they may also have a certain chance to develop into uncontrollable "addiction" .
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Historic breakthrough: Acupuncture and moxibustion research appears on Nature, and Harvard Chinese scholars provide modern neuroanatomical basis for the existence of acupoints
Time of Update: 2021-10-21
In 2020, a research paper published by Professor Ma Qiufu's team at Harvard Medical School in Neuron [1] revealed that low-intensity acupuncture to stimulate acupoints on the hind limbs of mice (such as Zusanli ST36) can activate the vagus nerve-adrenal anti-inflammatory pathway, while acupuncture stimulates acupoints on the abdomen (Such as Tianshu ST25) but cannot induce this anti-inflammatory pathway .
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Why do we need comfort when Nature's experiment failed?
Time of Update: 2021-10-21
In conclusion, the study showed that mice exhibited pro-social comforting behavior and revealed a neural circuit mechanism that is the basis for the coding and control of affinity touch during pro-social interaction .
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[Cell] Scientists at Harvard University have discovered a mechanism that helps explain why certain parts of the body are so sensitive to external perceptions
Time of Update: 2021-10-21
Recently, scientists at Harvard Medical School discovered a mechanism in a new study they led that could help They recognize what causes some skin areas to be more sensitive .
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To identify key pathogenic proteins in Alzheimer's disease, Harvard scientists develop important detection tools
Time of Update: 2021-10-21
. Recently, scientists have developed a sensitive detection method specifically designed to identify and quantify Aβ oligomers in the human brain, cerebrospinal fluid, and blood .
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For the prevention and treatment of acute ischemic stroke complications in the acute phase, see expert guidance!
Time of Update: 2021-10-21
④For patients with malignant middle cerebral artery infarction and severe intracranial pressure increase within 48 hours of onset and under 60 years of age, the condition is still aggravated by active drug treatment, especially for patients with lowered level of consciousness, please consult neurosurgery to consider whether to reduce it.
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Some parts of your body are too sensitive?
Time of Update: 2021-10-21
▲When the glabrous area (adult) is touched, the neuron signals in a specific brain area will be stronger, which is in sharp contrast with the hairy area (picture source: reference [2]) but the brain The stem is also eccentric, and brainstem neurons will have a stronger connection with sensory neurons in the hairless area, amplifying the signs of sensitive skin .
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Ischemic stroke with atrial fibrillation: timing of anticoagulation, treatment strategies... 5 hot issues addressed in one article
Time of Update: 2021-10-21
The following are major recommendations: 2021 American Heart Association (AHA)/American Stroke Association (ASA) recommendation: For patients with ischemic stroke or TIA combined with non-valvular atrial fibrillation, if there is no moderate to severe mitral stenosis or mechanical For valves, NOAC (apixaban, dabigatran, edoxaban, rivaroxaban) is recommended to be superior to warfarin to reduce stroke recurrence .
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The relationship between patent foramen ovale and migraine, dizziness and vestibular migraine, this article explains very clearly
Time of Update: 2021-10-21
Judging from the current research, whether it is the relationship between PFO and migraine or with vertigo or VM, most studies are still focused on clinical research.
No Relationship Between Patent Foramen Ovale and Migraine Frequency.
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Research by a team of Chinese scientists: High blood pressure is diagnosed around the age of 40, and the risk of dementia is the highest!
Time of Update: 2021-10-21
Recently, in a study published in the journal Hypertension under the Journal of the American Heart Association, a research team led by Guangdong Provincial People’s Hospital found that individuals diagnosed with high blood pressure between the ages of 35 and 44 are related to the whole brain and gray matter.
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Mol Cell Liu Sanxiong et al. reveal the mechanism by which non-classical PRC1 activates transcription and participates in brain development
Time of Update: 2021-10-21
On October 11, 2021, the New York University School of Medicine/Howard Hughes Institute of Medicine Danny Reinberg Laboratory (first author is Liu Sanxiong) published an online article titled "NRF1 association with AUTS2" in Molecular Cell magazine.
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One article clarifies: the diagnosis and treatment strategy for embolic stroke of unknown cause!
Time of Update: 2021-10-21
Source of ESUS emboli: cardiogenic Professor Chen Huisheng introduced that cardiogenic factors mainly include 4 types, namely cryptogenic atrial fibrillation, atrial heart disease, undiagnosed myocardial infarction, and patent foramen ovale .