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The pause key of life? Nature: Scientists find 'hibernating switch' for the first time in mouse brains
Time of Update: 2020-07-21
the artificial activation of these nerve cells can trigger the mice to enter a state similar to hibernation, which greatly reduces the body temperature and energy consumption.
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The study revealed the neural mechanism that regulates the aggressive behavior of male mice.
Time of Update: 2020-07-21
this study found that the VGluT1 positive neurons in the posterior amygdala of the ventromedial hypothalamic nucleus played an important role in aggressive behavior, and revealed the important function of direct projection from the supracortical structure to the hypothalamus in the process of aggressive behavior gating.
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Space multiscale singularity: the reason behind the diversity of brain rhythms? NSR research paper.
Time of Update: 2020-07-21
Liu Zonghua) recently published in the National Science Review (NSR) Published research papers, pointed out that the real brain structure network has a new singular state spatial multi-scale singular state, its formation is closely related to the symmetry of the network local connection (as shown in the figure below).
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Pan Bingxing's team made a series of important advances in the study of neural loop mechanisms caused by stress and excessive anxiety.
Time of Update: 2020-07-21
The results showed that the anxiety inducing effect of chronic stress was closely related to the up regulation of presynaptic glutamate transmitter release of dmPFC → BLA PNS.
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Nature's Immunology has a weighty map of the brain's genes that produce poisons.
Time of Update: 2020-07-21
in vitro cell experiments confirmed that asiviscin and ggstop, a GGT inhibitor, could inhibit the activation of microglia induced by fibrin and LPS, increase the level of glutathione, and reduce the production of ROS.
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Neuron. "Decision Tree" at the neurotransmitter release site
Time of Update: 2020-07-21
KAESER research team of Harvard Medical School published the article synapse and active zone assembly in the absense of presynaptic Ca2 + channels and Ca2 in the journal Neuron+ The active region is more like a social platform, which determines the location and functional characteristics of synaptic connections, and calcium channels are just VIP users of the platform.
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Nature peruse the details. Breakthrough, said good apoptosis, the nervous system partial lying on a cell focal death.
Time of Update: 2020-07-21
The author questioned the traditional view that the death and renewal of central nervous system cells is only the result of cell apoptosis in the process of brain development, and confirmed that cell scorch plays an important role in this process.
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EMBO reports . . . The team found that phosphatase PP2A was involved in regulating the pruning of dendrites during neuronal development.
Time of Update: 2020-07-21
In the process of animal development, neuronal maturation often requires selective removal of exuberant or unnecessary nerve branches, which is crucial for the establishment of mature neural circuits
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Molecular Psychiatry: Real Hammer! Another heavy-handed study in the field of the intestinal-brain axis, the driving force behind the onset of depression, was found. Intestinal Weekly.
Time of Update: 2020-07-21
Issue 114: depression; diet, antibiotics, nutrition absorption; obesity, weight loss genes; aspirin, colorectal cancer [junjunjun moment] - advertising space; Jingyun biological health assessment leader of Chinese people click on the picture to see the details.
Intestinal flora can resist or induce colorectal cancer by regulating immune cells!
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Nature sub-journal: Peripheral immune cells "kill" the brains of dying patients.
Time of Update: 2020-07-21
cohort studies have shown that the number of NK cells in peripheral blood of ALS patients is increased, but the role of NK cells in the immune regulation of ALS is not clear.
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The study revealed that rhythmic genes regulate depression caused by neuroinflammation by controlling chematist factors.
Time of Update: 2020-07-21
researchers from Lin Wenjuan, Key Laboratory of mental health, Institute of psychology, Chinese Academy of Sciences, conducted research on the above problems to explore whether rhythm genes affect neuroinflammation induced depression through regulating inflammatory factors.
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Cell . . . Qian Yongyou/Li Boxing teamed up to discover the regulatory mechanism of neuronal excitatory steady state.
Time of Update: 2020-07-21
Tsien Laboratory of New York University published the article "nervous activity co OPS LTP machine to drive potassium channel splitting and homeostatic spike Widening" in cell magazine, and found the molecular mechanism of excitatory homeostasis regulation.
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Meng Bo Soup . . . Gene editing precision "deletes" animal-specific memories - God's scalpel, or Pandora's box?
Time of Update: 2020-07-21
In the above research, Wanyou and Yiming team realized the projection and function specific gene editing in rat brain through CRISPR / cas9 technology, combined with anterograde / retrograde AAV vector and cell marker technology.
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Progress was made in the study of nighttime light-induced negative emotions.
Time of Update: 2020-07-21
this study is the first time to elaborate the loop basis and rhythm gating mechanism of nocturnal light induced negative emotions.
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The study revealed the neural mechanisms of opioid analgesics.
Time of Update: 2020-07-21
in order to analyze the mechanism of action of exogenous and endogenous opioids, the researchers used an experimental strategy of "knock out first, then restore the expression of MOR in situ", and specifically studied the function of MOR in the analgesic effect of opioids in different types of neurons.
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Nature Sub-Journal: Why is the age of the direction of the worse? It turned out to be a "compass" that disturbed the brain.
Time of Update: 2020-07-21
according to their findings, the main source of spatial location errors was that "noise" disturbed the brain's "compass", resulting in inaccurate perception of movement speed.
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Cell . . . Insomnia can cause death through the accumulation of reactive oxygen in the intestines.
Time of Update: 2020-07-21
Katherina as we all know, sleep is essential for survival. in the most primitive animals, there is an obvious similar sleep state. Severe sleep deprivation can cause fatal danger, but the underlying c
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Nature Sub-Journal: Reveals the neural mechanisms that run faster and farther away.
Time of Update: 2020-07-21
in addition, immunofluorescence assay showed that the number of glutamatergic neurons did not change after training, which indicated that there was a conversion from cholinergic to GABAergic in CPPN.
They found that during exercise, cholinergic neurotransmitter conversion from cholinergic to GABA occurs in the brain CPPN, which promotes the ability of motor learning.
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Nature: (with expert insight) non-classical pathways for spleen-brain regulatory immune function.
Time of Update: 2020-07-21
published in the main issue of nature on April 29, 2020, the paper "brain control of human immune responses amenable to behavioral modulation" published by Qi Hai research group of Tsinghua University, Zhong Yi research group and Hu Ji research group of Shanghai University of science and technology [2] explained the neurochemical and loop mechanism of the regulation of spleen plasma cell production by Shenjing system in humoral immunity.
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What about fever when you're nervous?
Time of Update: 2020-07-21
after the authors artificially activated the DMH – RMR pathway, it was found that the activity of neurons increased and brown fat began to produce heat; unexpectedly, heart rate and blood pressure also increased, which indicated that DMH – RMR pathway can coordinate various physiological responses under stress conditions.
