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Clin Infect Dis: A randomized clinical trial of high-dose rifampicin with or without levofloxacin

 Time of Update: 2022-05-24

Modified Rankin Score (MRS) over time, by ARM treatmentConclusions: In a trial of TBM in children, functional outcomes were generally favorable .
Lancet Oncol: 10-year follow-up results of high-dose radiotherapy plus long-term androgen deprivation therapy for prostate cancer

 Time of Update: 2022-05-21

The 5-year follow-up showed that 2 years of adjuvant androgen deprivation combined with high-dose radiotherapy significantly improved biochemical control, metastasis, and overall survival in patients, especially in high-risk patients .
JAMA Oncology: High-dose radiotherapy for high-risk prostate cancer, what is the optimal duration of ADT?

 Time of Update: 2022-05-01

Based on this situation and the lack of duration data to guide EBRT+BT treatment decisions, the researchers conducted this study to confirm Optimal ADT duration threshold associated with improved distant metastasis-free survival (DMFS) in high-risk prostate cancer patients .
NEJM: A single high-dose liposomal regimen of amphotericin B for HIV-associated cryptococcal meningitis

 Time of Update: 2022-04-19

with cryptococcal meningitis to an improved regimen (Day 1: single high-dose amphotericin B, per kg Body weight 10 mg + flucytosine for 14 days, 100 mg per day + fluconazole, 1200 mg per day) or WHO recommended regimen (amphotericin B deoxycholic acid, 1 mg
Taking high-dose vitamin D supplements for 5 years did not affect cardiovascular disease or cancer rates

 Time of Update: 2022-01-24

A University of Eastern Finland trial found that taking much higher-than-recommended doses of vitamin D for five years did not affect overall mortality or rates of cardiovascular disease or cancer in older men and women .
PPT Sharing Professor Chen Shi: Is a high-dose dexamethasone suppression test necessary?

 Time of Update: 2022-01-01

test (HDDST) is a preliminary method recommended in China’s guidelines to distinguish Cushing’s disease from EAS, but due to its insufficient sensitivity/specificity and high potential risks (blood sugar, blood pressure, electrolytes, infection
Shanghai Ruijin Hospital reported: How high is the neutralizing titer of serum Omicron after the third dose of inactivated vaccine?

 Time of Update: 2021-12-25

The researchers also tested the neutralization titers of the vaccinators' serum against the original strain of the new coronavirus and the Omicron mutant.
Amoxicillin in the treatment of childhood pneumonia, low-dose or high-dose, short-term or long-term?

 Time of Update: 2021-12-05

5% (49/401) of the children in the long course group required additional antibiotics within 28 days Treatment, the difference is 0.
Clin Cancer Res: Efficacy of high-dose IL-2 combined with stereotactic ablation radiotherapy in the treatment of metastatic renal cell carcinoma

 Time of Update: 2021-12-03

immunityThis is a phase II clinical trial to evaluate whether additional stereotactic ablation radiotherapy (SAbR) can promote tumor antigen presentation and improve the overall response rate of patients with metastatic renal cell carcinoma to high-dose IL2 (HR IL2) .
LEUKEMIA: Bortezomib-based induction, high-dose melphalan and lenalidomide maintenance treatment for myeloma up to 70 years old

 Time of Update: 2021-12-01

> . MEL200/ASCT is adjusted according to renal function . After MEL200/ASCT, two cycles of lenalidomide consolidation treatment (25 mg, day 1-21, repeated
Studies by many universities have found that high-dose intensive treatment is better for children with cerebral palsy

 Time of Update: 2021-11-05

/> The autonomous control ability of the side is impaired . >The research team included 118 children with HCP, aged 2 to 8, from Roanoke and Charlottesville, Virginia, and Columbus, Ohio . CHAMP randomly assigns
[JAMA] Can patients with severe COVID-19 really benefit from high-dose corticosteroids?

 Time of Update: 2021-11-04

The proportion of patients who survived 28 days and did not require life support was 42. 6%, and that of the 6 mg group was 40. 2%; the mortality rate of the 12 mg group and the 6 mg group were 27. 1% and 32. 3%, respectively
Bortezomib induction, high-dose melphalan and lenalidomide maintenance treatment for myeloma patients under 70 years old

 Time of Update: 2021-10-11

(IT), high-dose melphalan (MEL200) and autologous blood stem cell transplantation (ASCT), followed by consolidation and/or Maintenance treatment, these treatment research data focus on patients under 65 years of age .
Lancet Haemat: All-trans retinoic acid + high-dose dexamethasone may become a new first-line therapy for primary immune thrombocytopenia!

 Time of Update: 2021-10-10

All-trans retinoic acid plus high-dose dexamethasone as first-line treatment for patients with newly diagnosed immune thrombocytopenia: a multicentre, open-label, randomised, controlled, phase 2 trial .
Can high-dose vitamin C reduce the mortality of sepsis?

 Time of Update: 2021-09-30

Only for medical professionals to read and refer to clinical information, 1s to reach more cutting-edge clinical
Nutr Metab: A powerful tool for improving the physical and mental health and immune status of breast cancer survivors: Yoga + high-dose vitamin D!

 Time of Update: 2021-09-18

The high dose of vitamin D supplementation combined with yoga training improve the leukocytes cell survival-related gene expression Breast Cancer Survivors in.
Blood Cancer J: High-dose methotrexate can effectively prevent isolated CNS recurrence in DLBCL patients

 Time of Update: 2021-09-03

Preventive HDMTX can reduce the recurrence rate of isolated CNS but does not reduce the CNS-systemic recurrence rate, systemic recurrence rate, and it does not improve the patient's survival prognosis .
Clin Gastroenterology H: The use of high-dose vitamin D does not prevent the recurrence of Crohn's disease after surgery

 Time of Update: 2021-08-27

Vitamin D The results of this study confirmed that compared with placebo, high-dose vitamin D did not reduce the incidence of postoperative endoscopic or clinical recurrence in CD patients undergoing ileocolectomy and ileocolon anastomosis .
Clin Cancer Res: Early use of high-dose hormones to manage irAE is associated with poor prognosis of anti-PD-1 monotherapy for advanced melanoma

 Time of Update: 2021-08-26

Early use of high-dose-glucocorticoid for the management of irAE is associated with poorer survival in patients with advanced melanoma treated with anti-PD-1 monotherapy .
Taiwan's high-end vaccine announced the data of the second phase test, the seroconversion rate of 28 days after the second dose reached 99.8%?

 Time of Update: 2021-06-16

. m. that day. It was announced that the high-end vaccine (Medigen Vaccine Biologics) from Taiwan’s biopharmaceutical company Corp) developed the new coronary pneumonia

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