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Chemical activation and catalytic activation modification of activated carbon fiber
Time of Update: 2021-11-15
Gas-phase oxidation means that ACF is oxidized in the air at a temperature of 300-350℃ to produce oxygen-containing functional groups on the surface to improve hydrophilicity and surface acidity; liquid-phase oxidation is ACF reacts with acidic solutions such as nitric acid and sulfuric acid to introduce oxygen-containing groups.
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New progress in C-H bond activation: aromatization of ketones by β - C (SP3) - H activation
Time of Update: 2017-11-06
It is a hard and creative work to activate the inert C-H bond and then functionalize it directly Since 1970s, transition metal catalyzed functionalization of ketone β - C (SP 3) - H bond has been deve
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abnormal activation of the BRAF-dependent MAPK-ERK signaling pathway
Time of Update: 2023-02-03
Fig. 1: SPOP-mediated BRAF ubiquitination modification to regulate the pattern of MAPK-ERK signaling pathwayFeng Kai, a master's student in the School of Life Sciences (currently a doctoral student at the Institute of Phenotypic Group), and Qing Shi, a postdoctoral student, are co-first authors of the paper.
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of innate immune cGAS-STING pathway activation and inhibition of the pathogenesis of Alzheimer's disease
Time of Update: 2023-02-02
Information: style="margin-right: auto;margin-left: auto;outline: 0px;width: 30px;display: inline-block;">—END—The content is [iNature]iNatureCICL GMP SATASE (CGAS) DETECTS MICROBIAL AND HOST-DERIVED DOUBLE-STRANDED DNA IN THE CYTOPLASM TO TRIGGER CELLULAR INNATE IMMUNE RESPONSES IN A STIMULATOR OF INTERFERON GENES (STING)-DEPENDENT MANNER.
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DNA "modular" programmable strategies build bivalent ligands to achieve fine regulation of receptor activation
Time of Update: 2023-02-01
Recently, Xiao Zeyu's research group of Shanghai Jiao Tong University School of Medicine cooperated with Zhang Jian's research group to publish a research paper entitled DNA-modularized construction of bivalent ligands precisely regulates receptor binding and activation in Chem, an important sub-journal of Cell.
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The key to the wrong activation of the immune system
Time of Update: 2023-01-06
However, as a result of the cell's own nucleic acid recognition, the mechanism of interferon production also occurs in rare single-gene autoimmune diseases, in which case it can be precisely specified as a genetic defect," said Professor Rayk Behrendt, team leader at the Institute of Clinical Chemistry and Clinical Pharmacology at the Royal College of Physicians.
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The key to the wrong activation of the immune system
Time of Update: 2023-01-06
However, as a result of the cell's own nucleic acid recognition, the mechanism of interferon production also occurs in rare single-gene autoimmune diseases, in which case it can be precisely specified as a genetic defect," said Professor Rayk Behrendt, team leader at the Institute of Clinical Chemistry and Clinical Pharmacology at the Royal College of Physicians.
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Nature Reviews Molecular Cell Biology: New insights into the activation and functionality of AMPK
Time of Update: 2023-01-04
" In this review, the authors focus on the latest atypical pathways of AMPK, including AMPK's perception of mitochondria, DNA, and lysosomal damage, explore the role of AMPK in cancer, obesity, diabetes, nonalcoholic steatohepatitis (NASH), and other diseases, and reveal new insights into AMPK activation and function in researchers' darlings.
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NAR: Dongyu Zhao et al. of Peking University reveal the underlying mechanism of CHD6 transcriptional activation of carcinogenic pathways
Time of Update: 2023-01-04
1093/nar/gkac1090 Although CHD6 is a member of the chromatin domain helicase DNA-binding protein family, little is known about its exact role in chromatin remodeling or cancer disease.
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Nat Immunol—Zhirong Zhang et al. unveil a new mechanism of innate immune activation: NLRP3
Time of Update: 2023-01-01
Source—“Sister of the Logical Scripture Science“ Lanhan Life Sciences" Written by Maki Editor- Wang Sizhen ， Edited by Binwei Yang, Sizhen Wang The inflammasome is a multi-protein polymeric complex th
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The Neuro Oncol/Bosden team revealed the molecular mechanism of abnormal activation of the ribosome biogenesis pathway in glioma stem cells
Time of Update: 2022-12-30
iNatureGlioblastoma (GBM) is the most common and deadly primary brain tumor in adults. Despite some progress in diagnosis and treatment, the prognosis for patients with GBM remains poor. GBM is classi
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The HSS study revealed how ultraviolet light triggers immune activation and disease outbreaks in lupus patients
Time of Update: 2022-12-04
In a new study presented at the ACR Proceedings of the American College of Rheumatology 2022 Annual Meeting, researchers from the Hospital for Special Surgery (HSS) report that they have discovered a potential mechanism explaining this association: reduced lymphatic drainage, which contributes to the creation of photosensitivity and immune responses in lymph nodes.
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Gao Dong's group discovered the mechanism by which FOXA2 drives prostate tumor cell plasticity and KIT signaling pathway activation
Time of Update: 2022-11-15
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Nat Commun Shanghai Institute of Pharmaceutical Sciences collaborated to reveal the G protein selective coupling activation mechanism of class B GPCRs
Time of Update: 2022-11-14
On November 5, 2022, the team of Xu Huaqiang/Zhao Lihua of the Shanghai Institute of Materia Medica, Chinese Academy of Sciences, together with the team of Yu Xiao/Sun Jinpeng of Shandong University,
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Cancer Cell: FOXA2 drives the mechanism of prostate tumor cell plasticity and activation of the KIT signaling pathway
Time of Update: 2022-11-14
On November 3, the international academic journal Cancer Cell published online a research paper entitled "FOXA2 drives lineage plasticity and KIT pathway activation in neuroendocrine prostate cancer"
