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What factors may increase the risk of active TB? —Chinese large sample cohort study
Time of Update: 2022-10-01
This study aims to explore this study in depth the joint correlation between multiple factors in lifestyle (including smoking, low body mass index, physical inactivity, alcohol consumption, and low dietary quality) and the risk of active tuberculosis.
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Neurology: The role of cardiovascular risk factors on the association between physical activity and markers of brain integrity in older adults
Time of Update: 2022-08-12
Blood vesselAt baseline, participants in the Age-Well study completed a physical activity questionnaire and collected cardiovascular risk factors (systolic blood pressure, body mass index [BMI], current smoking status, high-density lipoprotein cholesterol , total cholesterol, and insulin levels) )) and multimodal neuroimaging (structural MRI, diffusion MRI, FDG-PET and florbetapir PET) .
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coagulation factor activity PK lupus anticoagulant
Time of Update: 2022-08-10
What kind of adventures will happen if the coagulation factor activity measurement meets the lupus anticoagulant positive?case aftercase by case by caseIn April 2022, in the daily work, the results of a coagulation factor activity measurement caught the author's attention, as shown in Figure 1, the patient's endogenous coagulation factor (FVIII, FIX, FXI, FXIII) activity was significantly reduced .
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IBD: Active disease in patients with inflammatory bowel disease is a risk factor for exacerbation of new coronary pneumonia
Time of Update: 2022-05-10
This retrospective observational study of COVID-19 patients with inflammatory bowel disease and SARS-CoV-2 infection showed that severe inflammatory bowel disease activity was the only independent risk factor for disease exacerbation in COVID-19 .
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IBD: Histological inflammatory activity and history of steroid use are risk factors for clinical recurrence in patients with ulcerative colitis
Time of Update: 2022-05-08
This study confirmed that in UC patients with MES of 0 or 1, histological inflammatory activity and history of steroid use were risk factors for clinical recurrence in UC patients .
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Medicago truncatula MtGSTF7 can be activated by the transcription factor LAP1 to specifically participate in the accumulation of anthocyanins
Time of Update: 2022-04-28
Dixon's team from the University of North Texas, published an article online in the Journal of Experimental Botany entitled MtGSTF7, activated by the MYB transcription factor LAP1, A research paper specifically participates in anthocyanin accumulation in Medicago truncatula , which revealed a different regulatory mechanism of anthocyanin and procyanidin accumulation in Medicago truncatula from that in Arabidopsis .
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Emerg Microbes Infect: A multicenter cross-sectional study on the prevalence and risk factors
Time of Update: 2022-02-17
Emerg Microbes Infect 2021 Nov 10;Liu X, Zhang L, Zhang F,Prevalence and Risk Factors of Active Tuberculosis in Patients with Rheumatic Diseases: A Multi-center, Cross-Sectional Study in China.
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New progress has been made in the study of the abnormal regulation mechanism of platelet activating
Time of Update: 2022-01-10
PAF-AH 1B2 knockdown tumor cells significantly down-regulate the expression of several key regulatory molecules in a variety of tyrosine kinase-mediated signaling pathways, and reduce the growth factor receptor pathway and PAF-AH 1B2- mediated cell proliferation.
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mRNA expression triple immunoregulatory factor Moderna immunotherapy shows preliminary anti-cancer activity
Time of Update: 2022-01-01
A few days ago, Moderna announced the preliminary phase 1 clinical trial results of its mRNA immunotherapy mRNA-2752 for the treatment of solid tumors and lymphoma patients .
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J Urol: Factors affecting the transition from active surveillance to treatment in patients with prostate cancer
Time of Update: 2021-09-29
Relationship, current knowledge is limitedRecently, researchers from the United States published an article in the journal J Urol, investigating the demographic and clinicopathological parameters related to the transition from active monitoring to treatment interval in male prostate cancer patients .
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JAMA Surg: Study on dynamic factors related to malignant lesions during the active monitoring of mucinous tumors of the intraductal nipple
Time of Update: 2021-05-31
cn/ipsen/sporty/show-details/3074/2">digestion of pancreatic cancer has recently been adopted by researchers to summarize the pathological characteristics and repeated observation data before surgery to determine the dynamic variables related to the development of IPMNs malignant tumors.
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transcription factor TFIIAγ does not participate in the activation and inhibition of rice bacterial blight Xa1 resistance
Time of Update: 2021-03-17
Editor in charge: Food Science 0 Original title: Professor Chen Gongyou's group from Shanghai Jiaotong University revealed that the basic transcription factor TFIIAγ does not participate in the activation and inhibition of Xa1 resistance to bacterial blight in riceOn February 5, 2021, the Journal of Experimental Botany published an online report titled "TALE-triggered and iTALE-suppressed Xa1 resistance to bacterial blight is independent of OsTFIIAγ1 or OsTFIIAγ5 in rice" by Professor Chen Gongyou's group from School of Agriculture and foodmate.
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BMC Gastroenterology: Risk factors for poor prognostication and impaired daily activity in patients with hemorrhagic gastric heteum ulcers
Time of Update: 2021-01-31
study aims to analyze risk factors for poor prognostication in HGU patients, including mortality and ADL impairment.
analysis of older subjects only showed that the use of PPI before bleeding was an important predictor of ADL damage (OR 8.24; 95% CI 2.36-28.7).
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Ann Rheum Dis: Disease activity, cytokines, cogeneration factors, and diabetes risk of rheumatoid arthritis
Time of Update: 2021-01-22
disease activity score (DAS28)-C reactive protein (CRP), obesity, age and men are associated with an increased risk of DM, while current smoking and methotrexate use have protective effects.
, it can be seen that in RA patients, high disease activity and increased cytokine/cytokine levels are associated with an increased risk of DM.
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Regulation of Transcription Factor Activity by SUMO Modification
Time of Update: 2020-12-13
Post-translational modification by SUMO is an important mechanism to regulate transcription.
Here we describe general strategies to address how post-translational modification by SUMO regulates the activity of aDNA -binding transcription factor.
