A study led by the National Institutes of Health and USU linked amyotrophic lateral sclerosis with a fat-making gene and developed a gene therapy .
Blood lipoprotein levels are linked to the risk of ALS in the future
Time of Update: 2021-09-19
A large epidemiological study published online in the Journal of Neurology, Neurosurgery and Psychiatry showed that some blood lipid biomarkers related to cardiovascular disease risk are also associated with lower risk of amyotrophic lateral sclerosis (ALS) Related .
JNNP: Comparison of cerebrospinal fluid and serum neurofilament light and heavy chains as biomarkers for differential diagnosis of ALS
Time of Update: 2021-09-11
Cerebrospinal fluid (CSF) and serum neurofilament light chain (NfL) and heavy chain (NfH) levels in patients with ALS are elevated compared with most other neurological diseases .
ALS gene therapy may enter the brain through HDO
Time of Update: 2021-08-26
barrier "In 2015, a study published by Tokyo Takanori Yokota Medical and Dental University and his colleagues showed that a so-called heteroduplex nucleic acid molecule oligonucleotide
Neuron Shao Lingxiao et al. Reveal the antidepressant mechanism of siloxibin
Time of Update: 2021-08-11
antidepressant-like behavior. Here, the researchers used the classic rapid antidepressant compound—ketamine as a positive control . Behavioral test results show that 1 mg/kg
JNNP: Genotype-related cerebellar features of ALS: focal cerebellar pathology and changes in brain-cerebellar connections
Time of Update: 2021-08-03
A prospective imaging study involving 271 participants systematically assessed the changes in cerebellar gray and white matter, cerebellar foot integrity, and brain-cerebellar connections in patients with ALS .
IEEE trans: Use fNIRS-based BCI system to strengthen communication between patients with advanced ALS
Time of Update: 2021-08-03
The results of the study show that in ALS patients, especially those in the later stages of the disease, it is feasible to develop a BCI system that communicates and controls through fNIRS data .
NEJM: Darlimumab combination therapy can help improve the prognosis of newly diagnosed AL amyloid patients
Time of Update: 2021-08-02
The darlimumab group has an advantage in survival rate without major organ deterioration or hematological progression (the hazard ratio of major organ deterioration, hematological progression, or death is 0.
Bojian refuses sympathetic use of experimental ALS drugs
Time of Update: 2021-07-14
Sandlock pointed out: "When considering a wider range of treatment options, we cannot ignore the patients in the current study, and cannot allow them to continue to use the placebo while providing tofersen to people outside of our study .
ALS new drug was the first to submit a marketing application in Canada and the US FDA was opposed by patient groups!
Time of Update: 2021-07-09
But in the United States, the regulatory time may be much longer, because Amylyx also just revealed that the US FDA hopes to see data from an additional placebo-controlled study before the company submits the AMX0035 marketing application .
2021 EHA Big Coffee Talks Professor Fu Weijun: First Look at the Progress of MM&AL Immunotherapy
Time of Update: 2021-06-17
≥PR were re-randomized into groups and received DARA maintenance treatment or observation respectively. Compare the two The efficacy of the group . The median follow-up
Geng Hao, Anhui Medical University, et al.: Exosomes and bladder cancer: new biomarkers and targets
Time of Update: 2021-06-11
JZUS-B welcomes outstanding scholars at home and abroad to contribute the latest scientific research results, controversial topics, review papers, and organize the publication of hot albums.
siRNA is expected to treat ALS gradual freezing
Time of Update: 2021-06-10
The report found that children with severe early-onset amyotrophic lateral sclerosis (ALS) have a rare mutation in the SPTLC1 gene, which encodes a key metabolic molecule responsible for the production of a class of sphingolipids.
Nat Microbiol | Du Xin et al. Reveal a new infection mechanism of the common human skin bacterium Staphylococcus epidermidis from "friend" to "enemy"
Time of Update: 2021-06-01
strains of Staphylococcus epidermidis are friendly, and which ones have become enemies? In the past two decades, research on the mechanism of Staphylococcus epidermidis infection has always been around the formation and structure of its
STTT: Cui Jun/Zhao Jincun et al. Reveal a new mechanism for the new crown nucleocapsid protein to promote host inflammatory response through phase change
Time of Update: 2021-05-22
The new crown pneumonia (COVID-19) epidemic caused by the new crown virus (SARS-CoV-2) is still raging around
Nature | Yu Jie et al. Reveal the composition of AMPAR complex in the hippocampus and the inhibitory mechanism of specific antagonists
Time of Update: 2021-05-21
The research team used single-molecule fluorescence imaging technology, electrophysiological experiments and cryo-electron microscopy to reveal for the first time the composition of the AMPAR complex in the hippocampus, the composition of accessory proteins, and the inhibitory mechanism of specific antagonists.