(E)-Alkene Peptide Bond Isosteres by Cuprate Opening of Vinyl Aziridines
Time of Update: 2021-02-26
Alkene isosteres are important nonhydrolyzable and rigidified analogs of peptide bonds.
Fig. 1. Geometry of peptide bond and alkene isostere.
Angelw: a series reaction of C-H functionalization and elimination of β - fluorine to synthesize amphiphilic alkenes
Time of Update: 2020-01-05
As a kind of unique structural group, amphiphilic alkenes have important applications in medicine, materials and other fields
Amphiphilic alkenes have unique properties
JACS: Iron catalyzed π - bond α - C-H functionalization: hydroxylation of alkynes and alkenes
Time of Update: 2019-12-15
In addition, the neutral σ - allylic iron complex formed by deprotonation reacts with a series of carbon / heteroatom electrophilic reagents to obtain the α - functionalized product (scheme 1E) of olefins.
JACS: synthesis of z-olefins from terminal alkynes and terminal alkenes by silver catalyzed hydroalkylation of Alkynes
Time of Update: 2019-11-07
Olefins are important intermediates in organic synthesis, which are common in drugs and other bioactive compounds
The π bond of alkenes not only hinders the rotation
JACS: Construction of cyclobutene by enantioselective [2 + 2] cycloaddition of alkyne and alkene Derivatives Catalyzed by cobalt
Time of Update: 2019-09-27
Then the author investigated the substrate range of cycloaddition of 1,3-alkyne and alkene derivatives (Figure 5).
by dehydroborization and transfer boration of alkenes catalyzed by zirconium
Time of Update: 2019-09-20
Author: VBE is an important intermediate in synthetic chemistry
They have been widely used in the synthesis of bioactive natural products
reagent and 1,1-addition of terminal alkenes by Ellman group of Yale University
Time of Update: 2019-08-28
(source: Nat. Catalyst.) in order to further prove the practicability of the reaction, the author prepared α - methylbranched amine 54 (Fig. 4C) in a yield of 64% at a scale of 5g.
JACS: stereospecific synthesis of e-alkenes from Terminal Alkynes by anti Markovian addition
Time of Update: 2019-08-16
In 2015, Gojko lalic group reported the copper catalyzed hydrogenation of terminal alkynes (scheme 1c) using alkyltrifluoromethylsulfonate as electrophilic reagent, providing an effective method for the synthesis of e-alkenes.
Research group of Professor Yang Luo of Xiangtan University: Study on the double bifunctionalization and acyl peroxidization of two different alkenes
Time of Update: 2019-07-29
The introduction of two atoms and groups (including carbon atom and heteroatom) into the two ends of olefin C = C can not only increase the diversity of product molecules, but also
Angelw: CO catalyzed intermolecular [2 + 2] cycloaddition of alkynes and alkenes
Time of Update: 2019-02-01
Recently, the naohiko yoshikai research group of Nanyang University of Technology reported the intermolecular [2 + 2] cycloaddition (scheme 1c) of alkynes and alkenes catalyzed by CO on angelw.chem.
realization of intermolecular heck coupling reaction between non activated alkenes and alkyl halides
Time of Update: 2018-12-03
Introduction heck coupling reaction is one of the important methods to construct carbon carbon bond
However, there are few reports on the intermolecular heck coupling
Zhang Wanbin, Professor of Shanghai Jiaotong University: the construction of stereochemistry
Time of Update: 2018-06-12
The author: Dr
Kou Xuezhen's chiral nitrogen-containing heterocyclic compounds exist in many natural products and drugs
Transition metal catalyzed
synthesis of alkylsulfonyl compounds by the three-component reaction of alkyltrifluorobotassium, sulfur dioxide and alkene
Time of Update: 2018-06-06
Recently, Professor Wu Jie's research group of Fudan University reported for the first time a method (scheme 1) for the synthesis of alkylsulfonyl compounds by the three-component reaction of potassium alkyltrifluorobborate, DABCO · (SO 2) 2 and olefins.
application of cf3so2cl -- promoting direct chlorination of alkenes and alkynes - trifluoromethylthiolation reaction
Time of Update: 2018-04-26
The bifunctional reaction of alkenes and alkynes with fluorine-containing groups is a hot topic in the field of organic fluorine chemistry
Trifluoromethyl sulfur group
Research group of Professor Song Qiuling of Huaqiao University: new progress in visible light induced functional group reaction of alkenes
Time of Update: 2018-01-11
In recent years, visible light induced organic chemical reactions have developed rapidly, which are characterized by mild conditions, various reaction modes and strong tolerance of functional groups.
J. Am. Chem. SOC.: copper catalyzed three component alkene amination
Time of Update: 2017-11-07
Summary: hull team developed copper catalyzed three-component carboamination reaction with olefins, alkyl halides and amines as raw materials.