Cirrhosis of the liver is a life-threatening disease, which causes more than 1 million deaths worldwide
Dig Dis Sci: Alpha-fetoprotein level is an important indicator of radical resection for patients with hepatocellular carcinoma
Time of Update: 2021-04-13
Screening In addition, studies have shown that AFP is an independent prognostic factor for patients with hepatitis B liver cancer (HBV-HCC) undergoing hepatectomy.
Acta Neuropathologica: The heterogeneity of alpha-synuclein fibril activity in patients with Lewy body dementia is related to disease phenotype
Time of Update: 2021-04-13
1007/s00401-021-02288-1" target="_blank" rel="noopener"> -synuclein fibril activity correlates to disease phenotypes in Lewy body dementia.
GUT: Alpha-1 antitase controls alcohol-related liver disease in mice and humans
Time of Update: 2021-02-25
compared the survival time, clinical and bio-chemical parameters, including differences in AAT serum concentrations, in patients with ALD and other liver lesions.
ASCO GU 2021: THE HIF-2 alpha inhibitor Belzutifan is visible in advanced renal transparent cell carcinoma
Time of Update: 2021-02-24
study (NCT03634540) further explores the efficacy of Belzutifan in combining cabotinib with patients with advanced cCRCC who were treated for the first time (queue 1) or who had previously received immunotherapy and TKIs (queue 2).
Clin Cancer Res: Combined inhibition of G alpha and MEK can significantly improve the therapeutic effect of grape membrane melanoma
Time of Update: 2021-02-11
the cell system and human grape membrane melanoma cell lines were used in heterogeneous transplantation studies to evaluate the therapeutic activity of single G alphaq inhibition and combined MEK inhibition.
Nat Chem Biol: Fbxo48 inhibitors reduce insulin resistance by preventing pAMPK alpha degradation
Time of Update: 2021-02-02
is considered an attractive therapeutic target for a wide range of diseases. in the recent study "A Fbxo48 inhibitor prevents pAMPK alpha degradation and ameliorates insulin resistance", researchers say they have identified an orphan Ubithin E3
J Clin Oncol: Amine restores the sensitivity of myeloid prosthet syndrome to EPI alpha and improves patient prognostication
Time of Update: 2021-02-01
study aims to clarify whether LEN therapy can restore and improve the response of low-risk, non-del (5q) MDS patients, who show anemia and are less likely to be ineffective or benefit from recombined erythymocytopenic therapy, to EPO α.
Nobel Prize target HIF-2 alpha new drug discovery with patent layout
Time of Update: 2021-01-11
/> the binding cavity found in the PAS-B domain of HIF-2 alpha has a space of about 290 s3. the HIF-2 alpha target in the research drug and molecular structure design highlights mentioned HIF-2 alpha target had to introduce the pioneer company
CD47/SIRP alpha finally went to the front of the stage Gilead, AbbVie became the main camp
Time of Update: 2021-01-10
are high expression CD47, CD47 by binding with macrophage surface subject SIRP alpha, can reduce the phagocytosis signal, thus avoiding cell removal! Studies have confirmed that CD47 is highly expressed in a variety of tumor cells, including myeloid
Pulsed-Field and Two-Dimensional Gel Electrophoresis of Long Arrays of Tandemly Repeated DNA: Analysis of Human Centromeric Alpha Satellite
Time of Update: 2021-01-04
The availability of the large-scale resolution of pulsed-field gel electrophoresis (PFGE) ( 3 , 4 ) has allowed an increased understanding of the genomic organization of long arrays of tandemly repeated DNA, including their overall size and internal polymorphic variation.
Immunoaffinity, Capillary Electrophoresis, and Statistics for Studying Intact Alpha 1-Acid Glycoprotein Isoforms as an Atherothrombosis Biomarker
Time of Update: 2020-12-08
In this study, a methodology to analyze these differences in forms ofthe alpha 1-acid glycoprotein (AGP) between healthy individuals and patients with two different vascular diseases is detailed.
PPAR-Alpha Cloning, Expression, and Characterization
Time of Update: 2020-12-04
PPARα is a ligand-activated transcription factor that plays an important role in the regulationof many genes involved in key metabolic processes.
MicroRNA Expression Profiling by Bead Array Technology in Human Tumor Cell Lines Treated with Interferon-Alpha-2a
Time of Update: 2020-11-03
microRNA detection platform to identify genes that are induced by IFNα in hepatoma- or melanoma-derived human tumor cell lines. Despite the enormous differences in expression levels between these models, we were able to identify microRNAs
Nature: Significant progress! It is revealed that eIF2 alpha enhances long-term memory by stimulating protein synthesis in inhibitory neurons.
Time of Update: 2020-10-23
networks --- excitation and inhibitory networks--- during memory consolidation. excitable neurons are involved in creating memory traces, while inhibitory neurons block background noise, allowing long-term learning to take place. study
The p38 alpha inhibitor Neflamapimod was clinically successful in the treatment of Stage II
Time of Update: 2020-10-21
At the 13th Clinical Trials (CTAD) of Alzheimer's Disease, EIP Pharmaceuticals announced that the central nervous system disease drug Neflamapimod (VX745) is treating patients with mild to moderate Louisian dementia (DLB), with Phase II trials reaching the primary endpoint.
Sansheng Jian anti-IL-4R alpha monoantial clinical trial was approved by NMPA.
Time of Update: 2020-10-12
611 can alleviate diseases such as endexual dermatitis by inhibiting IL-4R alpha and blocking signaling of IL-4 and IL-13.
Cell Biol Int: Intranscing delivery of SDF-1 alpha pre-treated stem cells improves the re-myelinization of cup multiple sclerosis.
Time of Update: 2020-10-12
, the results show that intranscular delivery of SDF-1 alpha pre-treated BMSCs has some effect on improving the re-myelinization of the multi-sclerosis cup model.