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ACS Omega: New coronavirus changes male fertility-related protein levels, and the changes persist after recovery

 Time of Update: 2022-05-17

analyzed protein levels in the semen of men who had recovered from Covid-19 and found that even those with mild or moderate symptoms had significantly lower sperm counts and motility after recovery, fewer normal-shaped sperm, and less Reproductive
Science first released the molecular level analysis of the Omicron spike protein, revealing the two

 Time of Update: 2022-02-21

The researchers say this shows that, despite numerous mutations along the way, the new Omicron variant retains the ability to bind to human receptors .
Science Announces Molecular-Level Analysis of World's First Omicron Spike Protein

 Time of Update: 2022-02-20

Source: UBC School of Medicine"Understanding the molecular structure of the viral spike protein is important as it can help us develop more effective therapeutic Omicron and related variants in the future," said lead author Sriram Subramaniam, Ph.
JAMA Neurol: During the onset of AD, how does the level of glial fibrillary acidic protein change in plasma and cerebrospinal fluid?

 Time of Update: 2021-11-13

In preclinical AD patients, the blood level of the reactive astrocyte proliferation biomarker glial fibrillary acidic protein (GFAP) is higher, which constitutes a promising candidate biomarker in the early stage of the disease .
Infection: C-reactive protein and procalcitonin concentration levels can guide the use of antibiotics in COVID-19 patients

 Time of Update: 2021-11-01

This study confirms that the PCT and CRP concentration levels of COVID-19 patients at the time of admission and during the course of the disease can help identify secondary bacterial infections and guide the use of antibiotic therapy .
INFECTION: The level of plasma interferon-γ-inducible protein 10 (IP-10) in humans is correlated with the severity of extrapulmonary tuberculosis

 Time of Update: 2021-09-28

The results of the study found that compared with healthy controls, patients with tuberculosis external pulmonary phenotypic disease had significantly increased plasma IP-10 levels (p <0.
Death or non-death under stress is determined by the regulation of MK2 protein level

 Time of Update: 2021-09-20

"When cells are exposed to high levels of stress, the p38-MK2 pathway is continuously activated to promote the degradation of MK2 protein, which is related to cell death .
The average protein level of pig feed is 15.7%, of which the protein of self-finishing pigs has been reduced

 Time of Update: 2021-09-13

of the whole feed for finishing pigs is the lowest. It is 12. 6%, and the highest is 14. 9%. It is expected that the protein consumption per kilogram of pork will be reduced by more than 10%
New research points to the importance of cholesterol in regulating the levels of key toxic proteins in Alzheimer's disease

 Time of Update: 2021-08-26

>▲Illustration of the mechanism of astrocytes regulating Aβ production through cholesterol transport (picture source: reference [2])>Using a mouse model that mimics Alzheimer’s disease, the researchers found
Positive interim results of human trials for the treatment of NASH: for the first time to reduce the level of key liver proteins

 Time of Update: 2021-08-08

The ARO-HSD developed by Arrowhead consists of a double-stranded RNAi trigger, which is used to selectively target HSD17B13 mRNA in liver cells to reduce the expression of HSD17B13 protein .
Innovative protein degradation therapy received first proof of concept in human body, which can reduce target protein level by 90%

 Time of Update: 2021-08-08

Retrieved June 28, 2021, from https:// /06/28/2253669/0/en/Kymera-Therapeutics-Announces-Positive-Interim-Results-from-Single-Ascending-Dose-Phase-1-Trial-of-KT-474-Demonstrating-Degrader-Proof-of -Mechanism.
Significantly reduce the level of tau protein AD antisense oligonucleotide therapy announced Phase 1 clinical data

 Time of Update: 2021-08-05

In patients treated with BIIB080, 8 weeks after the last dose (day 141), the total tau protein concentration in the cerebrospinal fluid showed a dose-dependent decrease.
Significantly reduce the level of STAT3 innovative protein degradation agent shows anti-cancer activity

 Time of Update: 2021-08-02

▲STAT3 has multiple roles in tumor survival and growth (picture source: reference [2])The latest preclinical research results show:Kymera has discovered a series of potent and selective STAT3 degradation agents, which are active against wild-type and clinically relevant mutant STAT3 .
Cell Death Dis: The expression level of BH3-only protein determines the response of hepatocellular

 Time of Update: 2021-07-30

>Therefore, individual analysis of BH3-only protein expression levels may help stratify certain TKI-based HCC treatment strategies . >The results of this study
Death or non-death under stress is determined by the regulation of MK2 protein levels

 Time of Update: 2021-07-29

"When cells are exposed to high levels of stress, the p38-MK2 pathway is activated in a continuous manner to promote the degradation of MK2 protein, which is related to cell death .
Abnormal protein levels may help predict the risk of Alzheimer's disease

 Time of Update: 2021-07-28

A new study conducted by American researchers found that the risk of Alzheimer's disease is related to abnormal levels of dozens of proteins in the blood, and this abnormality has begun to appear several years in advance .
Can reduce the level of pathogenic protein by 80%. The preliminary clinical results of RNAi therapy are positive

 Time of Update: 2021-07-28

Note: The original text has been deletedReference materials:[1] Dicerna Announces Interim Results From Phase 1 Trial of Belcesiran for Treatment of Alpha-1 Antitrypsin Deficiency-Associated Liver Disease.
Neurology: The relationship between the new TDP43 protein and the level of glycation in diabetic patients

 Time of Update: 2021-06-10

Blood vesselThe researchers pointed out that at the pathological level, the development of cognitive and behavioral abnormalities is related to the accumulation of hyperphosphorylated TDP-43 protein in the motor outer cortex .
Alzheimers Dementia: Pathological protein levels in cerebrospinal fluid, which can reflect the density of cortical neurons

 Time of Update: 2021-06-08

The important significance of this study is that it is found that NDI is a particularly sensitive marker of early cortical changes that occur before severe atrophy or the development of cognitive impairment.
BMC Gastroenterology: The levels of IL-17 and alpha-fetoprotein in plasma can effectively predict the risk of liver cancer in patients with liver cirrhosis

 Time of Update: 2021-04-22

Cirrhosis of the liver is a life-threatening disease, which causes more than 1 million deaths worldwide

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