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Purification of Bacteriophages and SDS-PAGE Analysis of Phage Structural Proteins from Ghost Particles
Time of Update: 2021-02-13
These particles should be preferred to the entire bacteriophages for one-dimensionalSDS -PAGE analysis of phage structural proteins, since running of the phage proteins through the gel is not disturbed by the presence of the phage DNA.
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Scientists have figured out the molecular structure of antifreeze proteins
Time of Update: 2021-02-01
This means that when these proteins come into contact with ice, the water molecules change to form different hydrogen bond structures and directions, rather than freezing.
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Chinese scientists have revealed the structure of cryogenic cryo-frozen electroscopes between the NSD protein family and the nuclear small complex
Time of Update: 2021-01-12
are essential for regulating the structure and gene expression of chromatin, and the imbalance of histone lysine methyl transferase is often directly related to a variety of cancers and other diseases. NSD family protein is a specific histoprotein H3
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Nuclear Magnetic Resonance Structural Studies of Membrane Proteins in Micelles and Bilayers
Time of Update: 2021-01-05
Nuclear magnetic resonance ( NMR ) spectroscopy enables determination of membrane protein structures in lipid environments, such as micelles and bilayers.
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Crystallization and Structure Analysis of Membrane Proteins
Time of Update: 2021-01-04
The structure of another, entirely different membrane protein, the bacterial outer membrane porin fromRhodobacter capsulatus , has now been determined by X-ray crystallography ( 6 ).
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Heavy! The Shi's team then solved the important protein structure of Alzheimer's
Time of Update: 2020-12-31
proteins, amyloid protein is one of its hydrolysis objects, this protein plaque deposits and Alzheimer's disease is very closely related. Yang told China Science Daily. Scientists have long developed disease treatment strategies around the principle
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The Chinese University of Science and Ology analyzes the structure of the human bile salt excret
Time of Update: 2020-12-30
cryoelectral technology to analyze the near-atomic resolution three-dimensional structure of the human bile salt excrete protein ABCB11, providing a basis for an in-depth understanding of the transport mechanism of this type of membrane protein
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Refinement of Protein and Nucleic Acid Structures
Time of Update: 2020-12-29
Refinement constitutes the last of the three main steps in the crystallographic establishment of a molecular structure, which are fast, crystal growth and data collection; second, phase determination and calculation of electron density
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Scientists "see" the structure of potassium-chlorine co-transport proteins
Time of Update: 2020-12-28
. In order to reduce the radiation damage of electrons to proteins, protein samples need to be collected in a frozen environment. Before the data was collected, the researchers used liquid ethane to quickly freeze the protein solution sample
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Solve the great challenges of biology for 50 years! The biological "AlphaGo" accurately predicts protein structure
Time of Update: 2020-12-21
today, DeepMind announced that its next-generation AlphaFold artificial intelligence system, which beat the rest of the participants in the International Protein Structure Prediction Competition (CASP), can accurately predict the 3D structure of proteins based on amino acid sequences.
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Structure-Based Chemogenomics: Analysis of Protein Family Landscapes
Time of Update: 2020-12-21
Analysis of the three-dimensional structures of protein ligand complexes provides valuable insight into both the common interaction patterns within a target family and the discriminating features between the different members of a target family.
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Protein Crystallization in Restricted Geometry: Advancing Old Ideas for Modern Times in Structural Proteomics
Time of Update: 2020-12-20
In the structural genomics period traditional methods for protein crystallization have been eclipsed by automation using batch or vapor diffusion equilibration to find conditions conducive for protein crystal growth.
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Structural Proteomics of Membrane Proteins: a Survey of Published Techniques and Design of a Rational High Throughput Strategy
Time of Update: 2020-12-17
Based largely on these observations, a robust strategy was then developed that rapidly identifies highly expressed membrane protein targets and simplifies their production for structural studies.
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Chemogenomics with Protein Secondary-Structure Mimetics
Time of Update: 2020-12-13
During molecular recognition of proteins in biological systems, helices, reverse turns, and β-sheets are dominant motifs.
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The big problem is broken, protein 3D structure can be analyzed by AI
Time of Update: 2020-12-13
DeepMind's research and development team says it will continue to train AlphaFold to better analyze more complex protein structures.
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Addressing the major challenges of biology over the past 50 years The biological community "AlphaGo" accurately predicts protein structure
Time of Update: 2020-12-11
performance of the best protein folding prediction system in the 2006-2020 CASP competition (Photo: DeepMind Blog) In this year's CASP, alphaFold scored 92.4 out of 92.4 for all protein target 3D structure predictions.
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NMR Screening for Rapid Protein Characterization in Structural Proteomics
Time of Update: 2020-12-09
NMR screening is a beneficial part of a structural proteomics pipeline because of its ability to provide detailed biophysical information about the protein targets under investigation at an early stage of the structure determination process.
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Overview of the Pipeline for Structural and Functional Characterization of Macrophage Proteins at the University of Queensland
Time of Update: 2020-12-09
This chapter describes the methodology adopted in a project aimed at structural and functional characterization of proteins that potentially play an important role in mammalian macrophages.
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Use of Residual Dipolar Couplings in Structural Analysis of Protein-Ligand Complexes by Solution NMR Spectroscopy
Time of Update: 2020-12-01
Recent advances in NMR methodology such as transverse relaxation–optimized spectroscopy (TROSY) and residual dipolar couplings (RDCs) measured in liquid crystalline alignment medium, offer a viable alternative to traditional nuclear Overhauser enhancement (NOE)-based approaches for structure determination of large protein complexes.
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Protein Structure Modeling with MODELLER
Time of Update: 2020-11-23
Automation of similar protcols has resulted in models of useful accuracy for domains in more than half of all known protein sequences.
