Macrocyclic Peptides with Endo Aryl-Aryl and Aryl-Alkyl Ether Bonds
Time of Update: 2020-12-01
The endo aryl-aryl and aryl-alkyl ether bonds exist in a number of biologically important macrocyclic natural products, such as vancomycin family glycopeptide antibiotics (1 –3 ), antitumor series RA I-XIV (4
JACS: Shihang group of West Lake University realizes amination of Ru (II) - catalyzed aryl fluoride by η 6-coordination
Time of Update: 2020-02-20
SOC.) conclusion: Shihang research group of West Lake University has developed a Ru catalyzed s-n-ar amination method of aryl fluoride by using semi stable bidentate ligands.
ACS catalyst: palladium catalyzed stereospecific cross coupling of a-boranyl copper with aryl bromide
Time of Update: 2020-02-17
The olefins containing bpin group can get the expected product in good yield, but the enantioselectivity is poor (D.R = 3:1); when using 1,8-diaminonaphthylboramide (bdan) substrate, a single enantiomer can be obtained in high yield.
Xia Chengfeng's team of Yunnan University has made achievements in visible light induced arylation of enol Heck
Time of Update: 2020-02-12
Recently, chemical science, the authoritative journal of the Royal Society of chemistry in the field of international chemistry, published on-line the research results of enol
Angelw: Paul knockel team reported the cross coupling reaction of (hetero) aryl halides with functionalized alkylzinc reagents catalyzed by cobalt
Time of Update: 2020-01-23
Int. ed.) in a word, the author reported the cross coupling reaction of various substituted (primary, secondary) alkylzinc reagents with aryl or heteroaryl halides catalyzed by cobalt.
Angelw: nickel catalyzed intermolecular and intramolecular metathesis of aryl thioethers via reversible arylation
Time of Update: 2020-01-02
The emergence of cross coupling reactions catalyzed by various metals (such as PD, Cu and CD) has greatly promoted the development of C-S bond formation, and various electrophilic precursors can be used to construct complex aryl thioethers (scheme 1a).
JACS of Newhouse group: Benzyl dehydrogenation of electron deficient Heterocyclic Aromatic Hydrocarbons Catalyzed by aryl nickel
Time of Update: 2019-12-25
Newhouse team reported the benzyl dehydrogenation of electron deficient Heterocyclic Aromatic Hydrocarbons Catalyzed by nickel, which uses ligands and oxidants to promote the β - hydrogen elimination process.
hydrogenation synthesis of chiral aryl α - glycine esters and their derivatives
Time of Update: 2019-12-21
Recently, Professor Zhang Wanbin's research group of Shanghai Jiaotong University has developed a highly efficient asymmetric hydrogenation of α - arylimine ester catalyzed by palladium acetate with low toxicity (org.
JACS: asymmetric synthesis of sulfimide -- arylation of sulfimide
Time of Update: 2019-12-13
Sulfimides are hexavalent sulfur compounds containing one oxygen atom, one nitrogen atom and two carbon substituents
When two carbon substituents are different
JACS: Dong guangbin's group has realized ruthenium catalyzed reduction and cleavage of non tension C (aryl) - C (aryl) bond
Time of Update: 2019-11-19
Recently, Dong guangbin's research group developed a ruthenium catalyzed reduction cracking method of C (aryl) - C (aryl) bond, and studied its mechanism (scheme 2C), which was published in J.
Peng Bo group of Zhejiang Normal University: dearylation of aryl high valent iodine
Time of Update: 2019-10-10
Recently, the team of Peng Bo of Zhejiang Normal University realized the dearylation of aryl high valent iodine by rearrangement reaction, and constructed a new dearylation reaction model.
The intramolecular cyclization of α - carbonyl thioylide on (hetero) aryl
Time of Update: 2019-09-25
In recent years, as a safe substitute of diazo compounds, the application of thioylide in metal catalytic reactions has attracted much attention
Angelw: asymmetric synthesis of chiral 2-aryl-2,3-dihydrobenzofuran derivatives
Time of Update: 2019-08-06
Chiral 2-aryl-2,3-dihydrobenzofuran derivatives widely exist in natural products and bioactive compounds (Figure 1)
Therefore, the development of new methods
JACS: LiCl accelerated cross coupling between aryl chloride and aryl trifluoromethylsulfonate
Time of Update: 2019-08-01
Biaryl compounds are widely used in pharmaceutical, agricultural chemistry and materials industry, but the availability of aryl metal reagents is still limited
of aryl ethylene and benzothiazole with N-heterocyclic carbene ligands
Time of Update: 2019-07-02
Author: with the increasingly serious environmental and resource problems, the development of green and efficient C-C bond formation method has become one of the most cutting-edge
Chem: Nuno maulide group realizes direct asymmetric arylation of amides by chemically selective α - oxidative sulfonation
Time of Update: 2019-06-29
(source: Chem) in order to avoid purification of the product, and trifluoromethylsulfonate has high chemical reaction activity, the author expects that α - OTF amides can be further functionalized to realize asymmetric α - arylation of amides.
Zhou Ling, Professor of Northwestern University: Construction of axially chiral aryl benzoindole
Time of Update: 2019-06-18
Recently, a series of biaryl axis chiral compounds with benzoindole naphthol skeleton have been constructed by Professor Zhou Ling's research group of Northwest University Based on the strategy of chirality transition.
ACS catalyst: Zhao Dongbing's research team of Nankai University realized C (SP3) - H bond arylation / amidation of silylmethyl
Time of Update: 2019-06-17
(source: ACS catalyst.) under the optimal reaction conditions, the author first investigated the substrate range (Figure 3) of diaryl iodotrifluoromethylsulfonate through the reaction with 2 - (tert butyl Dimethylsilyl) pyridine 1a.
JACS: carbon dioxide mediated C (SP2) - H arylation of primary and secondary benzylamines
Time of Update: 2019-05-16
Amines are widely found in polymers and drug molecules
In recent years, the rapid construction of amines by C-H functionalization has attracted the attention
bond arylation based on transient and recyclable halogenation process
Time of Update: 2019-05-13
Based on this consideration, Professor Wan Jieping of Jiangxi Normal University and other researchers designed and realized Suzuki coupling reaction based on the transient C-H bond halogenation mode for the first time, which provided a new way for isoflavones synthesis.