Positive selection maturation mechanism of germinal center B cells in Sci Immunol
Time of Update: 2022-04-30
A more popular model over the past 25 years is that germinal center B cells require affinity-based competition for cyclic reentry each time they enter the bright zone .
maturation antigen and CD19 CAR-T cells is safe and effective in the treatment of multiple myeloma
Time of Update: 2022-04-29
The combination of iNature anti-B cell maturation antigen (BCMA) and anti-CD19 chimeric antigen receptor (CAR) T cells induces high response rates in relapsed or refractory (R/R) multiple myeloma (MM) patients, but Long-term outcomes have not been assessed .
J Clin Oncol: Long-term efficacy of B-cell maturation antigen and CD19 chimeric antigen receptor T-cell combination therapy in multiple myeloma
Time of Update: 2022-04-24
Combination of anti-B-cell maturation antigen and anti-CD19 chimeric antigen receptor T cells induces durable remission in patients with refractory or relapsed multiple myeloma, with a median progression-free survival of 18.
Alz Res Therapy: Novel Single-Cell Marker Predicts Changes in Cognitive Function
Time of Update: 2022-03-05
The significance of the study lies in its finding that at 4 years of follow-up, baseline plasma MCP-1 levels were associated with longitudinal decline in overall cognitive and representational memory performance in older adults .
Front Immunol: Fibroblast-stromal cell markers predict imaging progression in active rheumatoid arthritis
Time of Update: 2022-01-21
diagnostic immunization Objective: This study aimed to investigate whether the addition of fibroblast-stromal cell markers to the classification of synovial pathological types could improve their predictive value for clinical prognosis in rheumatoid arthritis (RA) .
Science solves many years of puzzles: the genetic mechanism that coordinates the maturation of phloem cells
Time of Update: 2022-01-10
A continuous group of special phloem cells along the root (similar to the lane on a highway) transport the main nutrient-sucrose to the parts needed for plant growth .
Immune cell research guide: how to choose T cell markers
Time of Update: 2022-01-03
Like various helper T cell subsets, cytotoxic T cells also express specific transcription factors and produce different cytokines and effector molecules .
Fudan University "Cancer Research" published a paper: Cancer stem cell markers promote breast cancer by reshaping the immune microenvironment
Time of Update: 2021-12-25
, and self-renewal and multidirectional differentiation characteristics of stem cells are called “cancer stem cells (Cancer Stem Cells). Cells, CSCs)” .
the migration of mature T cells from the thymus to the periphery
Time of Update: 2021-11-02
of negative selection, before entering the mature state and preparing to emigrate , thymic T cells have undergone a physiological process in which the TCR signal ( CD69 ) decreases and the migration signal ( S1P1 ) rises. This precise
Stem cells rebuild the ovarian environment that promotes mature eggs
Time of Update: 2021-10-01
Researchers led by Kyushu University in Japan have successfully used mouse stem cells to reconstruct structures in the ovarian environment that are essential for the production of mature egg cells .
Cell protein genomics comprehensively identifies pancreatic cancer treatment targets and early diagnosis markers
Time of Update: 2021-10-01
The integration of protein genomics data allows researchers to link gene variants associated with pancreatic ductal adenocarcinoma to the functional modules that drive the disease phenotype .
Cancers: Markers and gene sets predicting the sustained response of Pembrolizumab in patients with non-small cell lung cancer
Time of Update: 2021-08-04
For this purpose, foreign research teams have carried out research to explore the markers and gene sets that predict the sustained response of pembrolizumab (Pembrolizumab) in patients with non-small cell lung cancer .
Red blood cell maturation agent Rotexip significantly improves anemia and quality of life in patients with transfusion-independent β-thalassemia
Time of Update: 2021-06-30
The purpose of this study is to evaluate the efficacy and safety of the world's first red blood cell maturation agent rotexip combined with best supportive therapy for the treatment of adult non-transfusion dependent (NTD) β-thalassemia .
The role of tumor-derived exosomes in the differentiation, maturation and functional changes of dendritic cells
Time of Update: 2021-06-16
Recently, researchers at Isfahan Medical University in Iran published an article titled "The roles of tumor-derived exosomes in altered differentiation, maturation and function of dendritic cells" in Molecular Cancer .
Early precursor T-cell acute lymphoblastic leukemia with SET-NUP214 fusion gene and expressing B cell markers
Time of Update: 2021-06-02
Defu Medical Publishing House published the latest article in the International Journal of General Medicine, an early precursor T-cell acute lymphoblastic leukemia with SET-NUP214 fusion gene and expression of B cell markers.
NEJM: The effect of anti-B cell maturation antigen CAR-T cell therapy bb2121 in the treatment of multiple myeloma
Time of Update: 2021-05-20
gov/31042825/" target="_blank" rel="noopener">Anti-BCMA CAR T-Cell Therapy bb2121 in Relapsed or Refractory Multiple Myeloma .
Br J Cancer: New diagnostic model to identify relevant markers and lipid disorders of esophageal squamous cell carcinoma
Time of Update: 2021-05-20
The results of this study identified 12 lipid biomarkers for establishing a diagnostic model and potential mechanism for diagnosing lipid disorders in the serum of ESCC patients.
Cell Stem Cell | Anti-aging as early as possible—Mature brains have already appeared with molecular aging characteristics of neural stem cells
Time of Update: 2021-05-09
In summary, this study showed that short-term and long-term NSCs exhibit asynchronous depletion through clone tracing, and single-cell transcriptome analysis of deep neural stem cells in the resting phase revealed molecular aging characteristics in mature brains.
[Cell Reports] The brain is still a child, but the hair is already bald...how much do you know about the maturation process of the brain?
Time of Update: 2021-04-18
a child, but the hair is already bald. . . So how much do you know about the maturity of the brain? Although there is a lot of knowledge surrounding brain development (for example, neurogenesis, neuron migration