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Ther Drug Monit: ABCC2 gene polymorphisms affect the efficacy and plasma concentration of lacosamide in children with epilepsy
Time of Update: 2022-11-25
The journal Therapeutic Drug Monitoring published a study evaluating the correlation between the ABCC2 1249G>A (rs2273697) and -24C>T (rs717620) genotypes and their haplotype and diploid combinations with the blood concentration and efficacy of lacosamide (LCM) in Uyghur children with epilepsy.
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Mol Biol Rep: Association of candidate gene (ALR2, RAGE, and VEGF) polymorphisms with diabetic retinopathy in patients with type 2 diabetes
Time of Update: 2022-11-25
Mol Biol Rep 2022 Nov 01 Background: Diabetic retinopathy (DR) is a complication of diabetes, a chronic condition associated with high blood sugar.
Mol Biol Rep 2022 Nov 01 Background: Diabetic retinopathy (DR) is a complication of diabetes, a chronic condition associated with high blood sugar.
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Science: Uncovering a molecular mechanism by which non-coding single nucleotide polymorphisms drive human gliomagenesis
Time of Update: 2022-11-15
abj2890 Scientists from Mount Sinai Hospital and other institutions have identified important clues for the prevention and treatment of human gliomas through research, and the relevant research results may provide new ideas and perspectives for revealing the biological changes behind the occurrence of gliomas.
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Endothelin-1 gene polymorphisms (G8002A) and endothelial monocyte-activated peptide II: role in vascular dysfunction in pediatric β-thalassemia patients
Time of Update: 2022-10-31
Research Objectives:To assess the ET-1 gene polymorphism (G8002A) in pediatric patients with β-thalassaemia (β-TM) as a potential genetic marker for vascular dysfunction and its possible relationship with EMAP-II, oxidative stress, and vascular complications.
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Diabetes Care: Vitamin D status, vitamin D receptor polymorphisms, and risk of microvascular complications in patients with type 2 diabetes
Time of Update: 2022-10-12
In this study, we aim to prospectively investigate the relationship between serum 25-hydroxyvitamin D [25(OH)D] and vitamin D receptor (VDR) polymorphisms and the risk of microvascular complications in diabetes.
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Genes Nutr: The interaction of CDKAL1 rs7747752 polymorphisms with serum L-carnitine and choline
Time of Update: 2022-10-12
Given CDKAL1's important role in proinsulin conversion and insulin resistance, it makes sense to explore whether CKDAL1 gene variants and low serum levels of L-carnitine, choline, and betaine have a synergistic effect on GDM risk in pregnant women in China.
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The Chengdu Institute of Biology has revealed the body color polymorphisms and information
Time of Update: 2022-10-01
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The treatment of brain cancer has always been a problem, and there are not many breakthroughs, and the first-line treatment of polymorphic glioblastoma
Time of Update: 2022-09-15
Previous treatment of brain MRI was used in July 2020 with rigofenibIn July 2020, patients began third-line therapy with rigofenib.
Previous treatment of brain MRI was used in July 2020 with rigofenibIn July 2020, patients began third-line therapy with rigofenib.
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KIBRA gene polymorphisms and gray matter structure and olfactory function in the brains of the elderly
Time of Update: 2022-09-15
Written by Song LinEditor-in-charge - Wang SizhenEditor — Binwei YangThe kidney and brain expressed protein (KIBRA) is a post-synaptic protein encoded by the WWC1 gene that regulates synaptic plastici
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Frontiers of Research Data from China! Correlation between TFF1 gene polymorphisms and kidney stone risk
Time of Update: 2022-09-07
Research resultsThe results of a case-control study of the two-phase design showed a significant increased risk of kidney stones in individuals with rs3761376 A alleles (AA and AG) compared with the GG genotype [corrected odds ratio (OR) = 1.
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JNNP: methionine homozygosity for PRNP polymorphisms and susceptibility to human prion disease
Time of Update: 2022-05-24
Here, we performed the current case-control study using this large database to assess the association of the codon 129 PRNP polymorphism, a major determinant of CJD, with the development of prion disease .
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Clin Gastroenterology H: PNPLA3 polymorphism reduces susceptibility to diabetes in patients with nonalcoholic fatty liver disease
Time of Update: 2022-03-03
Therefore, this study aimed to investigate the association between patatin-like phospholipase domain 3 (PNPLA3) rs738409 genotype and diabetes (DM) risk using a biopsy-proven nonalcoholic fatty liver disease (NAFLD) cohort and a longitudinal observational cohort .
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of the application of R2-CHOP regimen to effectively treat rare four-strike polymorphic mantle cell lymphoma
Time of Update: 2022-01-09
Figure 2 Morphology and immunophenotype of quadruple-strike pleomorphic MCL: Lymphoma cells have pleomorphic morphology (A) and express CD20 (B), BCL2 (C), BCL6 (D), Cyclin D1 (E) , MYC (F), CD21 (G), P53 (H), and have a high Ki67 index (I) In view of the overexpression of BCL6, MYC, Cyclin D1 and BCL2, interphase fluorescence in situ hybridization of these related genes ( FISH) analysis .
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Ann Oncol: Large-scale prospective GWAS identification of single nucleotide polymorphisms (SNPs
Time of Update: 2021-12-04
Recently, a team from Japan has carried out related research, trying to use genome-wide association studies ( GWAS ) methods to identify single nucleotide polymorphisms (SNPs) that can predict L-OHP-mediated PSN .
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Int J Epidemiol: Common genetic polymorphisms increase the link between chronic lymphocytic leukemia and non-melanoma skin cancer
Time of Update: 2021-11-02
Cancer (BCC), 825 cases of squamous cell carcinoma (SCC) and 12802 cases of controlled studies studied the relationship between the identified CLL locus and the risk of NMSC .