. >>Methods: 50 BALB/c male mice were randomly divided into 5 groups (n=10): control group ,
Discovery of biological pathways driving genomic alterations and bone metastasis in Ewing's sarcoma, a rare childhood cancer
Time of Update: 2022-05-11
The pathway the scientists discovered involves a receptor on the surface of cancer cells called Y5R, which plays a role in mediating the effects of hypoxia -- if it's blocked or turned off, genetic changes are limited, thereby suppressing tumors.
Neural pathway identifies key to pleasurable touch
Time of Update: 2022-05-11
" Researchers at the University of Washington's Center for Itching and Sensory Disorders have discovered a specific neuropeptide and a neural circuit that transmits pleasant touch from the skin to the brain .
Professor Chen Qijun's research group revealed that dihydroartemisinin regulates spleen immune cell heterogeneity through SOD3-JNK-AP-1 signaling pathway
Time of Update: 2022-05-01
group from Shenyang Agricultural University published a research paper entitled "Dihydroartemisinin beneficially regulates splenic immune cell heterogeneity through the SOD3-JNK-AP-1 axis" in Science China Life Sciences, revealing that DHA regulates
in elderly patients with heart failure [with the Chinese expert consensus on clinical pathway management for anesthesia in TAVR surgery (2018)]
Time of Update: 2022-04-30
Different from conventional thoracotomy, most patients have poor cardiac function, severe valve stenosis, and large transvalvular pressure difference.
Nat Neurosci︱ Down-regulation of neuroimmunity and synapse-related pathways in the amygdala
Time of Update: 2022-04-29
in BD patients (Source: Zandi, et al. , Nat Neurosci, 2022) In order to further study the biological significance of these genes, the researchers used weighted gene co-expression network analysis (WGCNA) to study the relationship between
team from Genentech discovered the neuronal signaling pathway that controls the proliferation of glial cells. Cell Press Dialogue with Scientists
Time of Update: 2022-04-27
The research group has defined a neuron-derived NMDAR-Ptgs2 signaling pathway, which can achieve transcellular control and regulation of glial cell proliferation during brain development and injury .
JCI︱Liang Zhang/Zhanxiang Wang's team discovered that autocrine pathway regulates oligodendrocyte differentiation and promotes remyelination
Time of Update: 2022-04-27
cell differentiation and homeostasis, and many studies have shown a link between COPII components and human diseases [3,4], such as Sec31 mutations leading to severe neurological syndromes [5] .
Cell Rep: Discovery of a new pathway for DNA transfer in the tumor microenvironment
Time of Update: 2022-04-25
In their latest study, published in Cell Reports, Crislyn D'Souza-Schorey, the Maurice Pollard Professor in the Department of Biological Sciences, and collaborators found that DNA "cargoes
The latest paper from Nature Communications of Sichuan University: Molecular mechanism of ligand entry into Sigma-1 receptor pathway
Time of Update: 2022-04-25
is associated with a variety of diseases such as neurodegenerative diseases, cancer, etc. The crystal structure of the human sigma-1 receptor (hσ1R) published in 2016 (Figure 1 left) shows
haematol: clinical significance of RAS pathway alterations in pediatric acute myeloid leukemia
Time of Update: 2022-04-24
A foreign research team analyzed NF1, PTPN11, CBL, NRAS, and KRAS changes in 328 pediatric patients with AML to determine the clinical significance of these changes .
The signaling pathway of traditional Chinese medicine to promote the healing of diabetic wounds
Time of Update: 2022-04-23
The study clarified the mechanism and potential of traditional Chinese medicine in promoting the healing of diabetic wounds from the perspective of signaling pathways .
regulates the activation of Hippo signaling pathway and inhibits the growth of lung cancer cells
Time of Update: 2022-04-21
of the activity of MST1/2 and the phosphorylation of MOB1. . In this way, MOB1 acts as a "signal strength sensor", which senses the intensity of upstream oxidative stress and undergoes different
Chinese scholar Science sub-journal: C/EBPβ/AEP pathway determines Alzheimer's disease and life expectancy
Time of Update: 2022-04-19
that cleaves some proteins, and these fragments gradually aggregate to Cause Alzheimer's disease, gradually destroy the patient's memory and thinking ability, and ultimately affect their ability to live in daily life
Xiamen University discovers a pathway that promotes remyelination
Time of Update: 2022-04-18
of the human spine may be thicker than that of a giant sequoia tree . The insulating myelin sheath wraps the nerve axon, so that the action potential between neurons can be conducted quickly.
BRCA: 30 Years of Wind and Rain from Gene Identification to Targeted Therapy
Time of Update: 2022-04-17
identification to cancer prevention>From genetic identification to cancer preventionSubsequent studies have improved our understanding of the complex roles and functions
Microbial regulation of two opposing central carbon metabolism pathways, glycolysis and gluconeogenesis, in changing environments
Time of Update: 2022-03-08
Starting from the basic metabolic regulation of microorganisms, this study uses multi-omics data and mechanism modeling to reveal the regulatory mechanisms of microorganisms on the two opposite central carbon metabolism pathways of glycolysis and gluconeogenesis under changing environments .
