>Proteolysis targeting chimera (PROTAC) is a bifunctional small molecule, in which the target protein ligand and E3 ubiquitin ligase ligand are linked together by a linking arm.
ACS Chem Neuro: Polymeric estrogen has the effect of protecting nerves
Time of Update: 2021-05-23
March 21, 2021 //---According to a recent study, a new type of polymeric estrogen developed by the Rensselaer Institute can provide neuroprotection when implanted in the spinal cord injury site, thereby preventing further damage.
Chem: To achieve deeper tumor photodynamic therapy, Zhejiang University Deng Renren/Zhou Min team develops new photosensitization technology
Time of Update: 2021-04-23
low-power density 808 nm laser irradiation. Compared with the traditional singlet-triple state PDT method, the lanthanide-triple state sensitization method has deeper tumor penetration and stronger anti-tumor
Nat Chem Biol | Rao Yu/Ying Meidan team designed CDK2 degradation agent and applied it to AML differentiation treatment
Time of Update: 2021-03-23
This work reports a new type of CDK2 selective degrading agent that achieves high-efficiency and low-toxicity in AML cell differentiation therapy, and provides a potential differentiation therapy for AML therapy.
J AGR FOOD CHEM: A high-salt diet may damage the liver
Time of Update: 2021-02-16
A new study published in the journal Journal of Agricultural and Food Chemistry suggests that a high-salt diet can also lead to liver damage in adults and embryos.
The FDA's committee of experts has asked the DEP-4 sugar-lowering drug to update safety information
Time of Update: 2021-02-03
The FDA's committee of experts met Tuesday to discuss long-term safety data for AstraZeneta's diabetes drug Ongliza and Takeda's diabetes drug Nesina.
Nat Chem Biol: Fbxo48 inhibitors reduce insulin resistance by preventing pAMPK alpha degradation
Time of Update: 2021-02-02
is considered an attractive therapeutic target for a wide range of diseases. in the recent study "A Fbxo48 inhibitor prevents pAMPK alpha degradation and ameliorates insulin resistance", researchers say they have identified an orphan Ubithin E3
CLIN CHEM LAB MED: High-efficiency liquid chromatography-series mass spectrometry to simultaneously
Time of Update: 2020-12-11
this study describes the effectiveness of liquid chromatography series mass spectrometry (LC-MS/MS) for simultaneous determination of HCQ and its two main metabolites, deethyl chloroquine (DCQ) and DDDCQ.
Heavy! Win paid $625 million for Peroxy Chem
Time of Update: 2020-12-10
Umtron's $625 million acquisition of PeroxyChem 's business to enhance the resource efficiency of the growth segment expanding hydrogen peroxide's high-margin specialty applications its strong growth and sound financial position
Ang Chem Int Ed: Scientists have developed a new collaborative anti-cancer combination therapy that could hopefully target multiple types of cancer
Time of Update: 2020-11-01
are too low to produce enough reactive oxygen, so scientists used a modified system to partially recover oxygen, in which photosensitive agents produce reactive oxygen when exposed to light. Enzymes in cells convert reactive oxygen into hydrogen
$640 million! Ingtron successfully completed the acquisition of Peroxy Chem.
Time of Update: 2020-10-22
the combined global business to generate $20 million in synergies, the same as previously reported figures, particularly in operations and logistics, product portfolio expansion and new technology development. These synergies will be fully realized
Analy Chem: Scientists have developed new tools to study the function of the human body's immune system.
Time of Update: 2020-10-22
15, 2020 // -- In a recent study published in the international journal Analytic Chemistry, scientists from the University of Alberta and other institutions developed a new tool to help study the function of the human body's immune system
Nat Chem Biol: Reveals the molecular structure of the effective treatment of multiple myeloma with the drug Pomadamine.
Time of Update: 2020-10-13
: Yamamoto, J., Suwa, T., Murase, Y. et al. ARID2 is a pomalidomide-dependent CRL4CRBN substrate in multiple myeloma cells. Nat Chem Biol (2020).doi:10.1038/s41589-020-0645-3.
Clin Chem: A year of vitamin D supplementation and marine Omega-3 fatty acids did not reduce systemic inflammatory status in older adults.
Time of Update: 2020-10-10
Observational studies have shown that vitamin D and marine omega-3 fatty acid (n-3 FA) supplements are associated with a decrease in systemic inflammation. , however, past test results have not been consistent. this randomized, double
J Biol Chem: Study reveals why Redsyvir may be treating new coronaviruses!
Time of Update: 2020-10-03
), and they hope it may also be effective in treating patients infected with the new COVID-19 strain. even if you know a drug works, if you don't know how it works, it can be a red flag," said Mattias Gtte, a virologist at the University of New China
Chem: Understanding the surface chemistry of SARS-coV-2 contributes to vaccine development.
Time of Update: 2020-09-10
August 14, 2020 /--- Based on a recent study, we need to better understand the surface chemical characteristics of the SARS-CoV-2 virus to reduce transmission and accelerate vaccine design.
CLIN CHEM LAB MED: Changes in immunofluorescence test results for HEp-2 cell antinuclear antibodies
Time of Update: 2020-08-24
all subjects assessed the HEp-2 IFA titration and staining patterns, as well as the traditional parameters of nine SLE disease activities.
Clin Chem: Macrogenome analysis shows clinical SARS-CoV-2 infection and bacterial or viral hyperinfection and implantation?
Time of Update: 2020-08-05
, unlike the target SARS-CoV-2 qRT-PCR test, macrogenomic analysis of these SARS-CoV-2 negative samples identified the candidate cause of respiratory symptoms in patients.
Angew Chem: Our scientists have developed D-type peptide suppression immunology checkpoints for cancer immunotherapy!
Time of Update: 2020-07-31
their method is based on the specific blocking of immune checkpoints based on stable "mirror" peptides.