-
of innate immune cGAS-STING pathway activation and inhibition of the pathogenesis of Alzheimer's disease
Time of Update: 2023-02-02
Information: style="margin-right: auto;margin-left: auto;outline: 0px;width: 30px;display: inline-block;">—END—The content is [iNature]iNatureCICL GMP SATASE (CGAS) DETECTS MICROBIAL AND HOST-DERIVED DOUBLE-STRANDED DNA IN THE CYTOPLASM TO TRIGGER CELLULAR INNATE IMMUNE RESPONSES IN A STIMULATOR OF INTERFERON GENES (STING)-DEPENDENT MANNER.
-
Neuron Liu Kai's team found that activating type II interferon and cGAS-STING signaling pathways in the nervous system can promote axon regeneration
Time of Update: 2023-01-06
On November 11, 2022, Liu Kai's research group of the Hong Kong University of Science and Technology published a long article "Driving Axon Regeneration by Orchestrating Neuronal and Non-neuronal Innate Immune Responses via the" in Neuron IFNγ-cGAS-STING Axis, found that by knocking out PTPN2 and adding type II interferon stimulated genes (ISGs) in neurons including the cGAS-STING pathway, it was possible to activate interferon stimulated genes (ISGs).
-
Neuron Liu Kai's team found that activating type II interferon and cGAS-STING signaling pathways in the nervous system can promote axon regeneration
Time of Update: 2023-01-06
On November 11, 2022, Liu Kai's research group of the Hong Kong University of Science and Technology published a long article "Driving Axon Regeneration by Orchestrating Neuronal and Non-neuronal Innate Immune Responses via the" in Neuron IFNγ-cGAS-STING Axis, found that by knocking out PTPN2 and adding type II interferon stimulated genes (ISGs) in neurons including the cGAS-STING pathway, it was possible to activate interferon stimulated genes (ISGs).
-
Immunity Intestinal flora initiates systemic antiviral immunity through cGAS-STING-IFN-I signaling
Time of Update: 2022-08-15
In mice, it was found that the intestinal flora maintains the basal level of IFN-I production in the resting state by activating the body's cGAS-STING signaling pathway, which plays an important role in the body's resistance to DNA and RNA virus infection .
-
Salmonella induces a cGAS-STING-dependent type I interferon response in mouse macrophages by triggering mtDNA release
Time of Update: 2022-08-11
. In this study, we report that in addition to TLR4-dependent responses, the cytosolic surveillance pathway (CSP) cGAS STING is also required to activate type I IFN responsesUnited States .
-
Induction of IL19 expression through JNK and cGAS STING to regulate DNA damage-induced cytokine production
Time of Update: 2021-12-24
Stress produces cytokinesDNA damage, such as damage caused by ionizing radiation or inhibition of DNA replication checkpoint kinases, activates the cGAS-STING pathway and the transcription factor NF-κB, thereby triggering the secretion of pro-inflammatory cytokines, such as IL-1, IL-6 and IL- 8 .
-
CGAs sting see nature again
Time of Update: 2019-05-28
Nucleic acids from bacteria or viruses can produce strong immune responses in the infected cells, and the detection of pathogen derived nucleic acids is the core strategy for the host to sense infecti
