approval to its anti-PD-1 antibody drug Baizean ® (tislelizumab injection) for the treatment of adult patients with unresectable or metastatic microsatellite instability-high (MSI-H) or mismatch repair deficient (dMMR) advanced solid tumors:
JCI: Children with complete IRF8 deficiency are susceptible to alveolar proteinosis and multiple infectious diseases
Time of Update: 2022-04-24
These results are representative of two independent experimentsFigure 2 Peripheral blood leukocyte, hemoglobin, and platelet counts and functions .
in the treatment of iron deficiency anemia in patients with inflammatory bowel disease
Time of Update: 2022-04-22
Long-Term Effectiveness of Oral Ferric Maltol vs Intravenous Ferric Carboxymaltose for the Treatment of Iron-Deficiency Anemia in Patients With Inflammatory Bowel Disease: A Randomized Controlled Noninferiority Trial.
J Clin Oncol: Efficacy of temozolomide in combination with low-dose ipilimumab and nivolumab in MSS and MGMT-deficient metastatic colorectal cancer (mCRC)
Time of Update: 2022-04-22
The primary endpoint was the 8-month progression-free survival (PFS) rate (calculated from the second part of treatment) .
Suspected deficiency of multiple coagulation factors caused by liver cirrhosis is actually...
Time of Update: 2022-04-21
> , respectively, FVIII: C11%, FIX: C 1%, FXI: C 2% , FXII: C 8%, lupus anticoagulant (LA) (SCT-NR: 2. 45, DRVVT-NR: 2. 01) . It was speculated that the decrease
J Gastroenterology: Zinc deficiency is a predictor of efficacy in chronic liver disease treatment
Time of Update: 2022-04-21
The results of this study confirmed that ALD, CONUT score, aspartate aminotransferase and hemoglobin were risk factors for zinc deficiency in chronic liver disease .
Endocrinol Metab: Adrenal morphology as an indicator of long-term disease control in adults with classic 21-hydroxylase deficiency
Time of Update: 2022-04-20
In recent studies, androstenedione, 21-deoxycortisol, and 11-oxyandrogen were recommended as reliable markers for disease control; Adrenal plethysmography has been used to assess normal adrenal size and to characterize specific diseases that may affect the adrenal parenchyma .
Eur J Endocrinol: Prenatal use of dexamethasone for classical 21-hydroxylase deficiency in a European population
Time of Update: 2022-04-20
through the placenta. Or reduce prenatal virilization . It has been in use since 1984, but its use is controversial for several reasons
JCEM: In adults with congenital adrenal hyperplasia with 21-hydroxylase deficiency, Crinecerfont reduces hormonal markers elevated by the disease
Time of Update: 2022-04-19
In adult patients with 21OHD, 14 days of Crinecerfont treatment reduced ACTH and had clinically meaningful reductions in elevated 17OHP, androstenedione, testosterone (women), or androstenedione/testosterone ratio (men) .
Lancet: Garadacimab is effective in preventing edema episodes in patients with C1 esterase inhibitor deficiency hereditary angioedema
Time of Update: 2022-04-17
Garadacimab (200 mg or 600 mg) every four weeks significantly reduced edema episodes in patients with C1 esterase inhibitor-deficiency hereditary angioedema and was well tolerated .
Professor Chen Feng's team published an important paper on "nutrient regulation of iron deficiency
Time of Update: 2022-04-15
Prebiotic oligosaccharides enhance iron absorption via modulation of protein expression and gut microbiota in a dose-response manner in iron-deficient growing rats. The research was completed in cooperation with the Institute for Advanced Study
The development of lithium battery testing equipment "smartly borrowed from the east wind" Although there are deficiencies, the future is bright
Time of Update: 2022-03-30
According to the current development status of the domestic lithium battery industry, the total investment corresponding to 1GWh of power lithium battery production capacity is about 600 million yuan, of which equipment investment accounts for 65%.
FDA Issues Complete Response Letter (CRL) for Somatrogon for Growth Hormone Deficiency (GHD)
Time of Update: 2022-02-18
First-line results from the pivotal Phase III trial showed that weekly Somatrogon (hGH-CTP) administered subcutaneously was non-inferior to once-daily Genotropin (hGH) .
ARD: The human SLE variant NCF1-R90H promotes renal injury and lupus murine through macrophage-deficient exocytosis to induce enhanced Tfh2 responses
Time of Update: 2022-02-17
CONCLUSIONS: The lupus pathogenic variant NCF1-H90 reduces macrophage burial, enhances Tfh2 responses, and promotes autoantibody production and renal injury in mice and SLE patients .
Clin Trans Gastroenterology: Iron deficiency associated with lower vitamin D levels in patients with inflammatory bowel disease
Time of Update: 2022-02-16
Iron Deficiency in Inflammatory Bowel Disease Is Associated With Low Levels of Vitamin D Modulating Serum Hepcidin and Intestinal Ceruloplasmin Expression.
