Deqi Pharmaceuticals and Pharmaceutical Biology, The whole pharmaceutical industry started
Time of Update: 2021-03-09
In response to the clinical needs of domestic and Asia-Pacific patients, Deqi Pharmaceuticals' independent research and development and cooperation have been introduced in step, with the layout of 6 innovative early-stage research and development projects, including ADC drugs.
Cover article: Drug Mingkangde has developed a visible light-mediated dehydration coupled reaction suitable for DEL
Time of Update: 2020-12-31
Molander team at the University of Pennsylvania applied visible light-mediated organic photochemical reactions to the synthesis of DNA-coded compounds, pushing research in the field to a new level.
Green oxidation and coupling reaction of furan and indole
Time of Update: 2020-02-17
Lead furan and indole are electron rich aromatic heterocyclic compounds, which are easy to oxidize and are important sources of other heterocyclic compounds, so they are widely
Nature catalysis: intermingled pumperer reaction activated metal free photocatalytic C-H / C-H coupling of aromatics
Time of Update: 2020-02-16
In order to simplify the synthesis process, the method of directly activating the C-H bond of the reaction substrate and selectively coupling C-H / C-H to obtain (hetero) diaryl structure has become more and more mature in recent years.
the palladium / WJ Phos catalyzed asymmetric Suzuki miyaara cross coupling reaction
Time of Update: 2020-01-26
(source: ACS catalyst.) Summary: the palladium catalyzed Suzuki miyaara cross coupling reaction has been developed by using WJ Phos as chiral ligand.
Angelw: Paul knockel team reported the cross coupling reaction of (hetero) aryl halides with functionalized alkylzinc reagents catalyzed by cobalt
Time of Update: 2020-01-23
Int. ed.) in a word, the author reported the cross coupling reaction of various substituted (primary, secondary) alkylzinc reagents with aryl or heteroaryl halides catalyzed by cobalt.
Angelw: decarboxylation coupling reaction of alkenylborate, halogenated compound and carboxylic acid
Time of Update: 2020-01-15
In organic synthesis, it is the pursuit of chemists to transform bulk chemicals into products with more complex structure and higher added value
JACS: chromium catalyzed selective C (SP2) - C (SP3) coupling reaction
Time of Update: 2019-11-17
However, the regioselective coupling of transition metal catalyzed alkyl Grignard reagent or organic zinc reagent with alkenyl or heteroaryl iodide mainly depends on Pd catalyst.
Green chem.: synthesis of cinnamamide derivatives from aromatic aldehydes, amines and Meldrum acids by three component coupling reaction
Time of Update: 2019-10-24
At present, the synthesis methods of cinnamamide or piperonamide mainly include (scheme 1a-1c): the coupling reaction between cinnamic acid derivatives and amines, or the oxidation amidation reaction of Cinnamaldehyde and Wittig or Horner Wadsworth Emmons reaction of aromatic aldehydes.
Li guigen, Nanjing University: copper and cobalt co catalyzed cross dehydrogenation coupling reaction of benzoxazoles
Time of Update: 2019-10-12
As an important structural unit, lead bis azaaryl compounds are widely found in drugs, functional materials, ligands and natural products
The cross dehydrogenation
ACS catalyst: Heterocyclic C-N coupling reaction catalyzed by Ni optimized by ligand design
Time of Update: 2019-09-29
(hetero) aromatic amines and N-arylated heterocyclic compounds have great application space in bioactive molecules, functional materials and other fields
of nonactivated olefins by series reaction of migration insertion / decarboxylation coupling under the catalysis of nickel
Time of Update: 2019-09-22
In 2019, Wang Chuan group used alkyl bromide as alkylation reagent to realize the aryl alkylation of non activated olefins catalyzed by reductive nickel (chem.
reduction coupling reaction for the construction of 2,3-Fused cyclopentyl indoline
Time of Update: 2019-09-13
Introduction olefins are cheap and easy to obtain, and also easy to prepare, which are important chemical raw materials
The transition metal catalyzed bifunctional
JACS: a new type of C-N cross coupling reaction developed by Mapu, Germany
Time of Update: 2019-08-30
SOC.) recently, Professor Tobias Ritter and others from Max Planck Institute of coal research in Germany have demonstrated for the first time that arylthiazolium salt can cross couple with N-nucleophiles.
of phosphine ligands derived from the framework of anthracene photodimers in palladium catalyzed coupling reaction
Time of Update: 2019-08-30
Recently, the research group of Conghuan, Institute of physics and chemistry, Chinese Academy of Sciences, has made new progress in the design of novel phosphine ligands for palladium catalyzed coupling reactions (org.
Research group of Professor Yan Hong of Nanjing University: the coupling reaction of nested carborane and nitrogen heterocyclic boron
Time of Update: 2019-07-28
Because of its unique physical and chemical properties, lead carborane has been widely used in coordination chemistry, material chemistry, pharmaceutical chemistry, supramolecular
Professor Zhong Guofu / Professor Zhang Jian, Hangzhou Normal University: iridium catalyzed cross coupling reaction of alkynes and alkynes
Time of Update: 2019-07-24
In order to realize the stereoselective synthesis of polysubstituted conjugated dienes, the research team developed a direct cross coupling reaction of acrylamide and alkynes catalyzed by ruthenium, with good stereoselectivity (org.
University reported the cross electrophilic coupling reaction of deamination of katritzky salt and halide catalyzed by Ni
Time of Update: 2019-07-17
In addition, alkylbromide can also be coupled with katritzky pyridine salt to form C (SP 3) - C (SP 3) bond, and the corresponding product 29 - 33 (Fig. 2C) can be obtained in medium yield.
decarboxylation coupling reaction of n-heteroaromatics and redox active esters catalyzed by copper
Time of Update: 2019-07-16
Source: ruthenium and iridium complexes of Professor Wang Qingmin's research group are widely used as photocatalysts for their strong visible light absorption, suitable redox
Green chem.: electrochemical synthesis of ketene by decarboxylation coupling reaction
Time of Update: 2019-07-04
Ketene amine is an important target molecule existing in natural products, materials science and pharmaceutical preparations
They are also used to synthesize