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Universal CAR-NK for relapsed/refractory B-cell lymphoma, 3/6 cases achieved CR

 Time of Update: 2022-05-25

), 3 with follicular Lymphoma (FL), 1 marginal zone lymphoma (MZL), 3 mantle cell lymphoma (MCL), 3 B-cell acute lymphoblastic leukemia (B-ALL) at high dose
Universal CAR-NK for relapsed/refractory acute myeloid leukemia (AML), 3/5 cases achieved CR

 Time of Update: 2022-05-25

The most intriguing clinical data is that high-dose ( 10x108 or 15x108 CAR -NK cells, 3 infusions) showed a good response in AML, with 3 CRs in 5 subjects, of which 2 had minimal MRD.
Lancet Haematol: Jin Jie / Zhu Honghu team used Veneclax + DA regimen to treat AML, the first CR was as high as 91%

 Time of Update: 2022-05-25

Of the 7 RUNX1-RUNX1T1 patients, 2 had a 3 log decrease in molecular levels after one course of DAV induction therapy, and 4 achieved complete molecular remission (CMR) (<0.
AACR 2022: 100% CR rate in 3 months!

 Time of Update: 2022-05-18

CORE1: Phase 2, single arm study of CG0070 combined with pembrolizumab in patients with non-muscle invasive bladder cancer (NMIBC) unresponsive to Bacillus Calmette-Guerin (BCG).
Br J Cancer: Effects of BRAF, KRAS and MSI on cytoreductive surgery (CRS) and hyperthermic

 Time of Update: 2022-04-23

/>3%) had MSI . Among mutBRAF tumors, MSI was more common in cases with both PM-CRC (50% vs 17. 9%, P=0. 047) and poorly differentiated tumors (83. 8% vs 15. 4%, P<
cardiac arrest: decreased total NAA/CR and increased LAC/CR, increasing the risk of irreversible!

 Time of Update: 2022-03-05

prognosis, few studies have examined the range of changes in brain-specific metabolic markers using TTM in adults . In neonatal patients with hypoxic-ischemic injury who received
Oncolytic virus CG0070 achieves 100% CR in high-risk bladder cancer patients Domestic Lepu Biotech has obtained clinical approval

 Time of Update: 2022-02-26

>Lepu Bio is also currently planning to initiate a clinical trial of CG0070 in combination with its core product HX008 for patients with advanced NMIBC (Putlimumab (HX008) is an anti-PD-1 monoclonal antibody product of Lepu Bio
Cases Shenghui | MSI-H advanced colon cancer patients achieved CR after 1 year of nvolizumab treatment!

 Time of Update: 2022-01-26

CT on May 16, 2019 Enrolled in the "Multicenter Phase II Clinical Study of Clinical Efficacy and Safety of Envolizumab Monotherapy in Patients with MSI-H/dMMR Advanced Colorectal Cancer and Other Advanced Solid Tumors".
The oncolytic virus CG0070 achieves 100% CR in high-risk bladder cancer patients, and the domestic Lepu Biologics has obtained clinical approval

 Time of Update: 2021-12-07

Recently (November 13th, 2021), CG Oncology disclosed the data of its dazzling Phase II clinical trial of its oncolytic virus drug CG0070 combined with K drug .
【OC Archives】Combined with a variety of underlying diseases, Nirapali decisively started to provide

 Time of Update: 2021-12-04

> . Tumor markers: CA-125 451. 8U/ml, HE4 374. 1pmol/l, CA-153 54. 84U/ml . CT outside the hospital before admission: left adnexal
[2021 ASH] APG-2575, a selective inhibitor of Bcl-2, was selected for two studies, and the Chinese clinical study showed CR

 Time of Update: 2021-11-14

to a maximum of 800 mg, and the median number of cycles received was 4 cycles (1-14). A total of 9 cases of CLL/SLL, 6 cases of mantle cell lymphoma (MCL), 3 cases of marginal zone lymphoma (MZL), 8 cases of follicular lymphoma, 2 cases of diffuse
Professor Han Weidong interviewed to quell CRS, tocilizumab escorted CAR-T precision treatment

 Time of Update: 2021-10-01

CRS treatment, but a process from prevention to treatment . Prevention of CRS: When it is clinically predicted that the patient may have severe CRS, low-dose TCZ (1-2 mg/kg) can
CR reached within 6 weeks of treatment, and the total diameter of the target lesion was reduced

 Time of Update: 2021-08-25

Among them, an open, single-arm, multi-center phase II clinical trial of MRG002 for the treatment of HER2-positive unresectable locally advanced or metastatic urothelial carcinoma after at least first-line systemic chemotherapy was launched in February 2021 .
GM-CSF: The new favorite of rheumatism immunity, the new crown CRS will be approved soon

 Time of Update: 2021-06-18

to the FDA based on good phase 3 clinical data. Use Authorization, EUA), is expected to become the first GM-CSF monoclonal antibody approved for clinical use for the new crown CRS indication .
Petrochemical Machinery Passed the Verification of National Science and Technology Major Special Archives

 Time of Update: 2021-06-07

-Year" national major science and technology special project "Development of key equipment and tools for deep shale gas development" comprehensive performance evaluation archives on-site verification jobs. They listened
GM-CSF monoclonal antibody combined with Yescarta, all CRS events are less than or equal to grade 3!

 Time of Update: 2021-05-09

reported that patients in the clinical study ZUMA-19 of the combination therapy of CAR-T therapy Yescarta (axicabtagene ciloleucel, Axi-Cel) and Lenzilumab Positive data, and based on this data plan to initiate a potential registration study.
Flt3 inhibitor AML produces CR: talk about off-target...

 Time of Update: 2021-05-03

Luxe was originally developed as a reversible BTK inhibitor and its main use is chronic leukemia, but so far it is still a substitute goalkeeper in this arena.
Flt3 inhibitor AML produces CR: talk about off-target activity

 Time of Update: 2021-04-27

Drug source analysisDrug source analysisLuxe was originally developed as a reversible BTK inhibitor and its main use is chronic leukemia, but so far it is still a substitute goalkeeper in this arena.
Case Sharing|To live up to the "Tuo", Tuoyi treats nasopharyngeal carcinoma with high risk of recurrence and metastasis up to CR!

 Time of Update: 2021-04-23

Table 2 Results of the second re-examination (after CCRT, in adjuvant treatment with teriprizumab) Case analysis The patient was diagnosed as "nasopharyngeal undifferentiated non-keratinizing carcinoma" (T3N3M0, stage IVa), with an EBV DNA of 1.
The first show of Guangdong Congress (Part 1): True and false CR after ALK-positive lung adenocarcinoma targeted therapy

 Time of Update: 2021-04-18

was evaluated as PR; after the treatment, sinus bradycardia occurred, and the dose of aletinib was reduced to 450 mg bid; the chest CT was regularly rechecked, and the nodules were unchanged. 2021-03-10 PET/CT showed

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