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tRNA-MaP: next-generation DNA sequencing for functional analysis of RNA-associated enzymes
Time of Update: 2023-02-03
Overview of tRNA-MaPThe genetic information encoded in genomic DNA is transcribed into mRNA, which is then transferred during protein synthesis (tRNAs) to decode codons on the mRNA.
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PNAS scientists have discovered messenger RNA with dual functions
Time of Update: 2022-10-13
A study led by Julian Chen and his team at the Center for Evolutionary Mechanisms at Arizona State University's School of Molecular Sciences and the Biodesign Institute has first discovered an unprecedented pathway to generating telomerase RNA from protein-coding messenger RNA (mRNA).
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The innovative team of crop pathogenic fungal functional genomics of Northwest College
Time of Update: 2022-10-01
Recently, the Crop Pathogen Fungal Functional Genomics Innovation Team of the College of Plant Protection published a research paper entitled "Uncovering Cis-Regulatory Elements Important for A-to-I R
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CELL MOL LIFE SCI Ji Xiong's research group reveals the functional mechanism of BRD2-mediated RNA polymerase II transcription
Time of Update: 2022-08-20
On June 4, 2022, Ji Xiong's group from the School of Life Sciences and the Life Center of Peking University published an online article entitled "BRD2 interconnects with BRD3 to facilitate Pol II transcription initiation and elongation to prime promoters for cell differentiation" in the journal Cellular and Molecular Life Sciences research paper .
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Yale scientists track longevity and multiple functions of messenger RNA
Time of Update: 2022-02-21
In one of the new studies, a team led by Nicole Martinez, a postdoctoral researcher in Gilbert's lab, found that pseudouridine plays a key role in the formation of mRNAs .
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Zhou Yufeng’s team first revealed the function and regulatory mechanism of circular RNA in allergic
Time of Update: 2022-01-10
The expression of hsa_circ_0004287 in PBMC of AD patients is up-regulated and negatively correlated with IL-6 and SCORAD Next, the authors constructed models of acute and chronic dermatitis in mice induced by calcipotriol (MC903) and 2,4-dinitrochlorobenzene (DNCB), and then applied the hsa_circ_0004287 overexpression plasmid locally with the help of in vivo transfection reagents To the skin of mice, the results showed that topical application of hsa_circ_0004287 plasmid significantly improved the skin inflammation in mice .
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RNA molecules with no obvious function represent a new method for the treatment of Candida fungal infections
Time of Update: 2022-01-09
Researchers from the comparative genomics laboratory of IRB and BSC in Barcelona have identified a series of RNA fragments that are not coded for proteins, but are related to the infection process of fungi belonging to the genus Candida .
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The latest data of the new AAV9-mediated RNA targeting system is released, which can correct
Time of Update: 2021-12-04
▲ DM1 disease development process (picture source: Locanabio official website) The modular RNA binding protein system developed by the CorRECTX™ platform can modify RNA through a variety of mechanisms, such as cutting, splicing, gene replacement, translation enhancement and editing .
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Qi Yijun's research group from the School of Life Sciences discovered the function of tRNA-derived small RNAs in plant antifungal defense responses
Time of Update: 2021-11-01
Qi Yijun’s group from the School of Life Sciences, Tsinghua University used a newly developed small RNA sequencing method to systematically analyze the 5′ tRNA halves and 5′ tsRNAs in the model plant Arabidopsis thaliana, and found that 5′ tsR-Ala regulates the expression of the target gene CYP71A13 and The synthesis of phytoalexins, thereby regulating the plant's antifungal defense response .
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Express is expected to bring a full oral treatment plan for hepatitis B functional cure, complete the first administration of RNA destabilizer
Time of Update: 2021-08-28
On August 16, 2021, Enanta Pharmaceuticals announced that the phase 1 clinical trial of EDP-721 has completed the first administration . EDP-721 is a new oral RNA destabilizing agent (destabilizer)
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It is expected to achieve functional cure for hepatitis B and complete the first administration of RNA destabilizer
Time of Update: 2021-08-27
EDP-721 is a new oral RNA destabilizing agent (destabilizer), as part of the all-oral combination therapy being developed for the treatment of chronic hepatitis B virus (HBV) infection, hepatitis B aims to achieve functional cure .
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Nature Sub-Journal: Functional Motif of Long Non-coding RNA Nron Anti-osteoporosis
Time of Update: 2021-08-10
The author’s research shows that Nron is a key negative regulator of bone resorption, and initially revealed that lncRNA functional motifs can be used as alternative functional molecules for disease treatment to reduce the possible pharmacological side effects of lncRNA-based drugs .
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Cell Death Differ︱ Song Xiaoyuan’s team reported on the molecular mechanism of long non-coding RNA
Time of Update: 2021-04-23
On March 24, 2021, Professor Song Xiaoyuan’s research team from the School of Life Sciences of the University of Science and Technology of China published a research paper entitled The long noncoding RNA Synage regulates synapse stability and neuronal function in the cerebellum online in Cell Death & Differentiation, reporting lncRNA Synage regulates the molecular mechanism of synaptic structure and neuronal function in the cerebellum.
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Scientists have revealed the important function of ring RNA in natural immunity
Time of Update: 2021-03-15
when long chains of RNA (RNA) "transform" into ring RNA, do these "remodeled" RNAs change even "intensions"? For the first time, the Chen Lingling research team at the Institute of Biochemistry and C
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Analysis of Catalytic RNA Structure and Function by Nucleotide Analog Interference Mapping
Time of Update: 2021-03-01
Nucleotide analog interference mapping (NAIM) is a quick and efficient method to define concurrently, yet singly, the importance of specific functional groups at particular nucleotide residues to the structure and function of an RNA.
NAIM can be utilized on virtually any RNA with an assayable function.