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Misfolded proteins in liver cells contribute to the development of liver cancer
Time of Update: 2023-02-03
"The findings suggest that gene therapy for hemophilia may increase the risk of liver cancer in some patients after years of treatment.
"The findings suggest that gene therapy for hemophilia may increase the risk of liver cancer in some patients after years of treatment.
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【Science Subjournal】Amazing lipid metabolism! The University of Chicago study has found a new protein that reduces the risk of liver cancer
Time of Update: 2022-11-01
A new study by researchers at the University of Chicago, "Lipid droplet turnover at the lysosome inhibits growth of hepatocellular carcinoma in a BNIP3-dependent manner," published in the journal Science Advances, shows that in a mouse model, BNIP3 The loss of protein leads to a decrease in the turnover of mitochondria and lipid droplets, which leads to the development of fatty liver and eventually liver cancer.
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New direction for research and development of hypoglycemic drugs: a protein secreted by the liver can lower blood sugar
Time of Update: 2022-07-04
Recently, Xinhua News Agency reported that researchers from Australia and other countries found that when the blood sugar level in the experimental mice is too high, the liver secretes a protein called secretory modular calcium binding protein 1, and animal experiments have shown that it is harmful to diabetes.
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J HEPATOLOGY: Liver fatty acid binding protein (L-FABP) in urine is a prognostic biomarker
Time of Update: 2021-10-09
The purpose of this study is to explore the effectiveness of plasma and urine L-FABP in predicting the prognosis and the development of ACLF in patients with decompensated liver cirrhosis (DC) .
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Clin Nutr: The higher the milk protein intake, the lower the risk of non-alcoholic fatty liver!
Time of Update: 2021-09-29
Among men and women ≥50 years of age, higher milk protein intake is significantly negatively correlated with the risk of NAFLD .
Among men and women ≥50 years of age, higher milk protein intake is significantly negatively correlated with the risk of NAFLD .
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Adv Sci Park Hailong Group uses metabolite-protein interaction network to define liver cancer subtypes with different prognosis
Time of Update: 2021-08-09
On July 11, 2021, Hailong Park’s research group from Dalian Institute of Chemical Physics, Chinese Academy of Sciences published an article titled Identification and characterization of robust hepatocellular carcinoma prognostic subtypes based on an integrative metabolite-protein interaction network in Advanced Science.
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Positive interim results of human trials for the treatment of NASH: for the first time to reduce the level of key liver proteins
Time of Update: 2021-08-08
The ARO-HSD developed by Arrowhead consists of a double-stranded RNAi trigger, which is used to selectively target HSD17B13 mRNA in liver cells to reduce the expression of HSD17B13 protein .
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deposition in human liver LO2 cells and regulate the expression of lipid metabolism-related proteins
Time of Update: 2021-03-17
Editor in charge: Food Science 0 Original title: Medium and long-chain triglycerides can reduce lipid accumulation in oleic acid-induced lipid deposition in human liver LO2 cells and regulate the expr
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Bio-clock protein can prevent liver-sourced diarrhea in piglets
Time of Update: 2021-02-23
ROR is an important biological rhythm-regulating protein, after verifying the relationship between ROR gamma and bile acid metabolism, the study found that in the liver of diarrhea piglets, the path of cholic acid synthesis is blocked, and the expression of ROR gamma and its genes is significantly reduced.
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Studies have found that a protein secreted by the liver lowers blood sugar
Time of Update: 2021-01-05
australia and other countries have found that a protein naturally secreted by the liver can lower blood sugar levels in mice with diabetes, hoping to develop new drugs to treat type 2 diabetes in the future.
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Free Flow Isoelectric Focusing: A Method for the Separation of Both Hydrophilic and Hydrophobic Proteins of Rat Liver Peroxisomes
Time of Update: 2020-12-24
To overcome these obstacles, we have elaborated a protocol for the separation of both hydrophilic as well as hydrophobic proteins using free flow isoelectric focusing (FF-IEF).
Similar to traditional gel-based isoelectric focusing, a denaturing electrophoresis buffer containing a mixture of urea, thiourea and detergents is applied to keep highly hydrophobic proteins in solution.
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Australian studies have found that a protein secreted by the liver lowers blood sugar
Time of Update: 2020-12-02
6 (Xinhua) -- Researchers in Australia and other countries have found that a protein naturally secreted by the liver can lower blood sugar levels in mice with diabetes, hoping to develop new drugs to treat type 2 diabetes in the future.
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World J Gastroenterology: Goerki Protein 73: A biomarker that evaluates cirrhosis and prognosis in patients with liver disease.
Time of Update: 2020-10-01
, there is still an urgent need in the clinic to assess the risk of cirrhosis and liver cancer with higher diagnostic accuracy and reasonable cost of novel serum biomarkers.
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World J Gastroenterology: Serum copper blue protein predicts liver fibrosis in patients infected with HBV.
Time of Update: 2020-10-01
Globally, about 292 million people have been or are infected with the hepatitis B virus (HBV); Chronic HBV infection can cause fibrosis and eventually develop into hepatocellular carcinoma, and the assessment of serum alanine amino transferase (ALT) levels is a relatively inexpensive biotransviral test that is widely used to detect liver damage.
developed CPHBV models using CP, plateplate (PLT) and HBsAg levels to predict significant fibrosis.
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Nogo-B protein complex: "non-alcoholic fatty liver" pathogenesis research progress.
Time of Update: 2020-09-14
studies confirm that this accumulation of fat is due to a decrease in NgBR levels leading to the nuclear transfer and activation of the central molecule liver X-receiving alpha, which regulates the synthesis of fatty acids in the liver, and is closely related to the inactivation of the adenosine activation protein kinase alpha, which enhances the function of energy metabolism sensors in the body.