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Cell: The structural basis of the mechanism of action of the potent analgesic fentanyl and morphine revealed by Shanghai Medicine
Time of Update: 2023-01-06
On November 10, 2022, the team of Xu Huaqiang/Zhuang Youwen, Xie Xin and Wang Mingwei of the Shanghai Institute of Materia Medica, Chinese Academy of Sciences cooperated to publish a research paper en
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Cell: The structural basis of the mechanism of action of the potent analgesic fentanyl and morphine revealed by Shanghai Medicine
Time of Update: 2023-01-06
On November 10, 2022, the team of Xu Huaqiang/Zhuang Youwen, Xie Xin and Wang Mingwei of the Shanghai Institute of Materia Medica, Chinese Academy of Sciences cooperated to publish a research paper en
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Cell Shanghai Drug reveals the structural basis of the mechanism of action of the potent analgesic fentanyl and morphine
Time of Update: 2023-01-06
On November 10, 2022, the team of Xu Huaqiang/Zhuang Youwen, Xie Xin and Wang Mingwei of the Shanghai Institute of Materia Medica, Chinese Academy of Sciences cooperated to publish a research paper e
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Cell Shanghai Drug reveals the structural basis of the mechanism of action of the potent analgesic fentanyl and morphine
Time of Update: 2023-01-06
On November 10, 2022, the team of Xu Huaqiang/Zhuang Youwen, Xie Xin and Wang Mingwei of the Shanghai Institute of Materia Medica, Chinese Academy of Sciences cooperated to publish a research paper e
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Cell: The structural basis of the mechanism of action of the potent analgesic fentanyl and morphine revealed by Shanghai Medicine
Time of Update: 2023-01-04
On November 10, 2022, the team of Xu Huaqiang/Zhuang Youwen, Xie Xin and Wang Mingwei of the Shanghai Institute of Materia Medica, Chinese Academy of Sciences cooperated to publish a research paper en
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Sci Immun Novel circulating iNKT cells exhibit highly potent antitumor and antiviral activity
Time of Update: 2022-11-26
This study is the first to discover a subpopulation of circulating iNKT cells in vivo, and reveals the characteristics of this cell subset and the differentiation mechanism regulated by IL-15 within the thymic immune microenvironment, as well as its efficient anti-tumor and antiviral immune functions.
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IHMT-CSF1R-833 was found to be a potent and selective CSF1R inhibitor
Time of Update: 2022-11-14
14 nM, which inhibits phosphorylation of CSF1R and its downstream signaling pathway in a dose-dependent manner.
14 nM, which inhibits phosphorylation of CSF1R and its downstream signaling pathway in a dose-dependent manner.
14 nM, which inhibits phosphorylation of CSF1R and its downstream signaling pathway in a dose-dependent manner.
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Researchers from the Institute of Microbiology collaborated to discover highly potent antibodies and super-neutralizing epitopes of yellow fever virus
Time of Update: 2022-10-25
In this study, 8 strains of antibodies bound to YFV-E protein were obtained, of which 2 strains had super neutralizing activity and had a highly effective therapeutic effect on mice infected with yellow fever virus.
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In addition to blood sugar control, may glimepiride have potent antioxidant, anti-inflammatory and angiogenic properties?
Time of Update: 2022-10-19
Type 2 diabetes mellitus is a metabolic disorder characterized by chronic hyperglycemia due to progressive defects in insulin secretion against the background of insulin resistance, which often leads
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1229705-06-9 is a potent and selective MDM2 antagonist
Time of Update: 2022-10-03
HC1374516-07-0TUG-891133053-19-7Go6983(96 %)1207253-08-4MK1064133052-90-1GF109203X199986-75-9CVT 3131796596-46-7NSC23005 Sodium6314-70-1NSC23005Chinese Name: RG7388 Inhibitor Edanoline 4-((2R,3S,4R,5S)-3-(3-Chloro-2-fluorophenyl)-4-(4-Chloro-2-fluorophenyl)-4-Cyano-5-neopentylpyrrolidine-2-carboxamide)-3-methoxybenzoic acid English name: Idasanutlin4-[[(2R,3S,4R,5S)-3-(3-chloro-2-fluorophenyl)-4-(4- chloro-2-fluorophenyl)-4-cyano-5-(2,2-dimethylpropyl)pyrrolidine-2-carbonyl]amino]-3-methoxybenzoic acid CAS No.
HC1374516-07-0TUG-891133053-19-7Go6983(96 %)1207253-08-4MK1064133052-90-1GF109203X199986-75-9CVT 3131796596-46-7NSC23005 Sodium6314-70-1NSC23005Chinese Name: RG7388 Inhibitor Edanoline 4-((2R,3S,4R,5S)-3-(3-Chloro-2-fluorophenyl)-4-(4-Chloro-2-fluorophenyl)-4-Cyano-5-neopentylpyrrolidine-2-carboxamide)-3-methoxybenzoic acid English name: Idasanutlin4-[[(2R,3S,4R,5S)-3-(3-chloro-2-fluorophenyl)-4-(4- chloro-2-fluorophenyl)-4-cyano-5-(2,2-dimethylpropyl)pyrrolidine-2-carbonyl]amino]-3-methoxybenzoic acid CAS No.
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Central memory T cells are the most potent precursors of resident memory T cells in human skin
Time of Update: 2022-08-11
. effector memory T cells (TRelative length unit) has the highest conversion rateRinggitin vitro and in vivo, but central memory T cells (Tcentimeter) lasts longer in the cycle, enters the skin in greater quantities, and produces more TRinggitAll in all, Tcentimeteris a highly efficient precursor to human skinRinggit, a feature that may underlie their known association with effective long-term immunity .
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Here comes the "game-changing" synthetic potent antibiotic: kills only bacteria, not tissue
Time of Update: 2022-04-28
A new, powerful "game-changing" antibiotic could save millions of lives around the world from drug-resistant superbugs, according to new research from the University of Liverpool .
MRSATeixobactin was first hailed as a "game-changing" antibiotic in 2015, but the new study developed a simplified synthetic version of the compound .
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Br J Dermatol: Suckinumab shows potent and durable efficacy in nail psoriasis
Time of Update: 2022-04-17
The current ad hoc analysis was designed to explore whether the efficacy of Suckinumab in clearing nail psoriasis (ie, achieving complete or near complete clearing) over the next 2-5 years would be in patients with PSA and concomitant nail psoriasis vary and maximize the dataset .
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How a potent anti-fibrotic peptide works and why it reverses scarring in multiple organs
Time of Update: 2022-01-25
Feghali-Bostwick, they discovered that the E4 peptide reverses fibrosis or scarring in human and mouse tissue by activating an antifibrotic pathway that is common to all organs and systems .
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Yasheng Pharmaceutical's new and potent EED inhibitor research results are published on JMC
Time of Update: 2021-11-04
The leading journal in the field, the Journal of Medicinal Chemistry, published an article revealing the potential of the potent oral embryonic ectodermal development protein (EED) inhibitor EEDi-5273 (ie APG-5918), which is expected to regulate tumor epigenetics and tumor microenvironment Overcome tumor drug resistance and achieve complete and lasting tumor regression .