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The final blow of dying cancer cells: the release of ATP to send a message to help neighboring cancer cells develop resistance
Time of Update: 2023-01-04
On November 16, 2022, researchers from the Georg-Speyer-Haus Institute for Tumor Biology and Experimental Therapeutics in Germany published a research paper in Nature entitled: Colon tumour cell death causes mTOR dependence by paracrine P2X4 stimulation。 The study found that when chemotherapy drugs cause colorectal cancer cells to die, they release ATP (which acts as the cell's energy currency and also as a messenger substance).
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Surprise! Dying cancer cells also leave "last words" to neighboring tumor cells to instruct how to survive!?
Time of Update: 2022-11-25
Although cancer research in recent years has been able to significantly improve early diagnosis and treatment, resistance to conventional chemotherapy for advanced colorectal tumors remains a major problem and largely contributes to the high mortality rate of patients with such tumors.
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Dev Cell: Dying cells protect their neighbors to maintain tissue integrity
Time of Update: 2021-08-02
Scientists from the Pasteur Institute and the French National Center for Scientific Research today revealed a new process that allows eliminated cells to temporarily protect their neighboring cells from death, thereby maintaining tissue integrity .
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"Dying" cells protect neighbors from "immortality"
Time of Update: 2021-08-01
French scientists have recently revealed a new process that allows "dying" cells to temporarily protect their neighbors from death, thereby maintaining tissue integrity .
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The determination of multi-dyed red blood cell microkernels in mice bone marrow.
Time of Update: 2020-10-30
Experimental method and step (1 ) cyclophosphamide treatment: 24h before taking bone marrow, the mouse abdominal cavity was injected with cyclophosphamide at a dose of 100mg / kg animal body weight.
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Bacterial self-sacrifice: Dying cells absorb large amounts of antibiotics to keep neighboring cells alive and continue to grow.
Time of Update: 2020-08-05
Andrej Ko?mrlj, an associate professor in the Department of Mechanical and Aerospace Engineering at Princeton University, worked with the CSUN team to develop a mathematical model to explain the phenomenon more fully and to help with further research.
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Nature sub-journal: Peripheral immune cells "kill" the brains of dying patients.
Time of Update: 2020-07-21
cohort studies have shown that the number of NK cells in peripheral blood of ALS patients is increased, but the role of NK cells in the immune regulation of ALS is not clear.