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Hypoxia-activated precursor drugs sensitized by nano-photosensitizers for precise treatment of gliomas
Time of Update: 2023-02-01
Conclusion of the study In summary, the biologically safe iRGD@ZnPc+TPZ nanomaterials constructed in this study can pass through the BBB, target penetration and enrich into the deep tumor, promote hypoxia activation of TPZ through PDT, realize the intelligent combination of PDT and chemotherapy, realize the precise delivery of drugs to the brain, significantly inhibit the growth of glioma, reduce toxic side effects, and prolong the survival time of glioma-loaded mice.
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Associate Professor Tang Wenting from Qingdao Agricultural University published research results on active peptide liposome precursors in Food Chemistry
Time of Update: 2022-01-21
Main research content01Physicochemical properties of walnut peptide liposome precursorThe average particle size of walnut peptide liposome precursors with sucrose, trehalose and mannitol as freeze-drying protective agents/carriers is about 200 nm, the absolute value of zeta potential is greater than 30 mV, and the encapsulation efficiency is higher than 60% , indicating good stability after hydration .
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PNAS bacterial rhamnolipid and its precursor 3-hydroxyalkanoate activate Arabidopsis innate immunity through two independent mechanisms
Time of Update: 2021-10-10
First, the author detected the production of apoptotic reactive oxygen species triggered by RLsec (a mixture of RL homologues and HAA precursors released by Pseudomonas) in Arabidopsis and whether RLsec induces the semi-biological vegetative plant pathogen syringa The local resistance of Pseudomonas proves that RLsec induces immune-related signals and disease resistance in Arabidopsis thaliana, partly mediated by the lectin RK LORE .