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Nature: Significant progress! Ursodeoxycholic acid, which was originally used to treat liver
Time of Update: 2022-12-30
In a new study, researchers from research institutions such as the University of Cambridge in the United Kingdom and the Charité Inky in Berlin, Germany, looked at miniature organs, donor organs, ani
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mechanism of liver bile acid metabolism affecting intestinal barrier function
Time of Update: 2022-09-15
The study found that the liver bile acid metabolism enzyme CYP8B1 remotely inhibits the self-renewal of crypt-based intestinal stem cells (ISCs) through its product bile acid (CA), preventing intestinal epithelial barrier repair and aggravating the inflammatory response.
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New research has uncovered molecular mechanisms by which bile acid metabolism in the liver affects intestinal barrier function
Time of Update: 2022-09-15
Finally, the researchers applied the FXR agonist Obequicholic Acid (OCA) to indirectly inhibit the activity of CYP8B1 in mice with colitis, which promoted the proliferation and passage of Lgr5+ ISC, and verified the important role of the liver FXR-CYP8B1-CA metabolic axis in IBD.
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evidence of "liver treatment of intestinal diseases" - the liver bile acid metabolism axis regulates the repair of intestinal epithelial damage
Time of Update: 2022-09-06
Reviews | Liejun Guo (Rutgers University), Wei Jia (Hong Kong Baptist University, The Sixth People's Hospital Affiliated to Shanghai Jiao Tong University)Editor-in-charge | The intestinal barrier is e
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Clin Trans Gastroenterology: Association of serum and fecal bile acid patterns with liver fibrosis in patients with nonalcoholic fatty liver disease
Time of Update: 2022-08-12
. This study demonstrated that NAFLD patients had higher fecal and serum BA and C4 concentrations with a risk of worsening fibrosis, suggesting that abnormal BA metabolism is associated with NAFLD fibrosis progression .
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BMC Gastroenterology: Serum uric acid to high-density lipoprotein cholesterol ratio is associated with the pathogenesis of nonalcoholic fatty liver disease
Time of Update: 2022-05-11
It has been suggested that the ratio of UA to high-density lipoprotein cholesterol (HDL-C) (UHR) can be used as a useful indicator for the diagnosis of hepatic steatosis, however, there is currently limited information on the relationship between UHR and the incidence of NAFLD in non-obese people, so , This study aimed to determine whether UHR can be used to independently assess NAFLD risk in non-obese Chinese individuals with normal lipid levels .
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JCEM: Association of serum uric acid levels with nonalcoholic fatty liver disease
Time of Update: 2022-04-24
In this study, researchers used a Mendelian randomization (MR) study to investigate the relationship between serum uric acid levels and non-alcoholic Causal relationship between fatty liver disease .
Serum Uric Acid Levels and Non-alcoholic Fatty Liver Disease: A Two-sample Bidirectional Mendelian Randomization Study .
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Mol Cell: Zhu Jian's research group reveals the mechanism of essential amino acids against fatty liver disease
Time of Update: 2022-04-22
So, can we use Drosophila to study the starvation response mechanism of liver cells and answer the question of why malnutrition causes fatty liver disease?Schematic diagram of lipid metabolism regulation in humans (left) and Drosophila (right)Schematic diagram of lipid metabolism regulation in humans (left) and Drosophila (right)On March 3 , 2022 , a research paper titled "Amelioration of hepatic steatosis by dietary essential amino acid-induced ubiquitination" was published online in Molecular Cell by Prof.
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Dig Liver Dis: Serum bile acid and glycol deoxycholic acid levels in patients with cystic fibrosis can be used as biomarkers of liver disease
Time of Update: 2022-01-07
The results of the study showed that, except for Glycyrrhiza deoxycholic acid (GDCA), bile acid levels in CF patients were higher than those in healthy controls .
Serum GDCA and deoxycholic acid (DCA) can distinguish CF patients from patients with non-cirrhotic liver disease (GDCA-AUC: 0.
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J HEPATOLOGY: Liver fatty acid binding protein (L-FABP) in urine is a prognostic biomarker
Time of Update: 2021-10-09
The purpose of this study is to explore the effectiveness of plasma and urine L-FABP in predicting the prognosis and the development of ACLF in patients with decompensated liver cirrhosis (DC) .
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JGH: Omega-3 fatty acid emulsion can safely and effectively reduce endotoxemia and sepsis in acute chronic liver failure
Time of Update: 2021-08-03
Omega-3 fatty acid lipid emulsions are safe and effective in reducing endotoxemia and sepsis in acute-on-chronic liver failure: An open-label randomized controlled trial.
Omega-3 fatty acid lipid emulsions are safe and effective in reducing endotoxemia and sepsis in acute-on-chronic liver failure: An open-label randomized controlled trial.
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Medium and long-chain triglycerides can reduce lipid accumulation in oleic acid-induced lipid
Time of Update: 2021-03-17
Editor in charge: Food Science 0 Original title: Medium and long-chain triglycerides can reduce lipid accumulation in oleic acid-induced lipid deposition in human liver LO2 cells and regulate the expr
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Is "horse bell acid causing liver cancer" a real hammer or a misreading?
Time of Update: 2021-02-26
Simple, Han Zeguang's team's research revealed that the use of horse bell acid alone can cause liver cancer in mice, showing dose dependence, that is, the larger the dose of horse bell acid, the shorter the time to cause liver cancer, and the larger the tumor.
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Horse bell acid is just one of the "suspects" of liver cancer
Time of Update: 2020-12-20
Horse bell acid causes changes in the genome A→T nucleotides, however, other carcinogens can also cause such mutations.
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Sci Transl Med: Scientists have found that amino acid targets associated with the development
Time of Update: 2020-12-19
6, 2020 // -- A recent article in the international magazine Science Translational Medicine entitled "Glycine-treatment ameliorates NAFLD by modul fattatingy acid oxidation, In a study by Glutathione
