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abnormal activation of the BRAF-dependent MAPK-ERK signaling pathway
Time of Update: 2023-02-03
Fig. 1: SPOP-mediated BRAF ubiquitination modification to regulate the pattern of MAPK-ERK signaling pathwayFeng Kai, a master's student in the School of Life Sciences (currently a doctoral student at the Institute of Phenotypic Group), and Qing Shi, a postdoctoral student, are co-first authors of the paper.
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Br J Cancer: miR-199b-5p-DDR1-ERK signaling pathline mediates emT processes to inhibit the metastasis of prostate cancer
Time of Update: 2020-12-23
in PCa, DDR1 is a target mechanism study of miR-199b-5p, which shows that miR-199b-5p inhibits the expression of the gene by directly targeting the 3'-UTR region of DDR1, ultimately suppressing the superskin-interstate transformation (EMT)-related esoteric esoteric transformation (EMT) induced by the DDR1 activation ERK signal path.
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RAS-RAF-MEK-ERK: A full line of classic tumor signaling paths.
Time of Update: 2020-09-10
Figure 2.1: RTK-RAS-RAF mutation incidence of different malignant solid tumors (Source: ) Although the development of important-point varieties K-Ras is very important, so far there have been no varieties on the market, clinical stage varieties are not particularly many The more representative varieties are Salirasib of Ono Pharmaceuticals (non-small cell lung cancer, pancreatic cancer), and Prolexys' PRLX-93936 (to adapt to multiple myeloma).
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Extracellular signals regulate P19 cell proliferation and differentiation through ERK kinase phosphatization Lin28.
Time of Update: 2020-09-09
On February 8th the international academic journal Journal of Biochemistry published online the latest findings of the Gao Daming Research Group of the Institute of Biochemistry and Cell Biology of the Chinese Academy of Sciences, entitled Extracellular-Signaled Kinases (ERKs) Phosphorylate Lin28a Protein to Modulate P19 Cell Proliferation and Evolution.
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RAS-RAF-MEK-ERK: A full line of classic tumor signaling paths.
Time of Update: 2020-09-03
1.2 MAPK pathway activation and feedback regulation (Source:) The relationship between signaling pathways and tumors As described above, Ras is a GTP binding protein that has been an important target for cancer research to date.
