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Synthesis of DNA-Binding Polyamides: Robust Solid-Phase Methods for Coupling Heterocyclic Aromatic Amino Acids
Time of Update: 2020-12-16
Currently, most DNA-binding therapeutics target short sequences of DNA with rather low selectivity, causing deleterious effects in both diseased and healthy cells ( 1 ).
Thus, the development of molecules that target longer, more cell-type-specific sequences of DNA is of great interest.
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New progress has been made in the study of methanol and carbon monoxide coupling for aromatics
Time of Update: 2020-12-15
Recently, Liu Zhongmin and Zhu Wenliang of the National Engineering Laboratory of Methanol Olefins of Dalian Institute of Chemical Physics of the Chinese Academy of Sciences made new progress in the study of aromatics made by the coupling of methanol and carbon monoxide.
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Nature catalysis: intermingled pumperer reaction activated metal free photocatalytic C-H / C-H coupling of aromatics
Time of Update: 2020-02-16
The construction of (hetero) diaryls is a key application of cross coupling reaction, because the structure of (hetero) diaryls is common in drugs, pesticides and functional materials Traditional cros
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Green chem.: synthesis of cinnamamide derivatives from aromatic aldehydes, amines and Meldrum acids by three component coupling reaction
Time of Update: 2019-10-24
Cinnamamides are a kind of important compounds, which have a wide range of biological activities, such as anti-cancer, anti malaria, anti Trypanosoma, anti-oxidation, anti diabetes, anti microbial act