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    lysine water

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    • JMC: Novel water-soluble "azolinium" selectively modifies lysine residues of peptides and proteins

      Time of Update: 2022-09-09
      As a result, after continuous structural optimization, the primary amino group [1] of amino acid derivatives and peptides is selectively modified in n-butanol solvents, and the chemical and site-selective modification of peptides, proteins and lysine of living cell proteins can be carried out in the physiological environment[2], providing a new class of cationic bullet-water-soluble "azolin ammonium" for target discovery and covalent drug design.
    • JMC's new water-soluble "oxazolinium" selectively modifies lysine residues in peptides and proteins

      Time of Update: 2022-09-06
      Recently, Associate Researcher Li Bo and Zhu Weiliang of Shanghai Institute of Materia Medica, Chinese Academy of Sciences, together with Professor Ge Guangbo of Shanghai University of Traditional Chinese Medicine, designed and developed a new type of water-soluble primary amino group based on the method of primary amino group modification in n-butanol solution previously developed by the team [1].

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