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    • PNAS article|Mi Kaixia's research group and John Innes Research Center in the United Kingdom
      Time of Update: 2021-03-22
      Quinolone drugs inhibit the enzymatic activity of bacterial DNA gyrase and topoisomerase IV to block the DNA replication and RNA synthesis processes necessary for growth. Studies have found that the pentapeptide repeat protein MfpA in mycobacteria regulates the activity of gyrase by mimicking DNA and participates in protecting it from fluoroquinolone drugs.
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