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Alveolar macrophages help CD8+ T cells protect against viral infections
Time of Update: 2023-02-03
+Given that the lung is the main tissue of IAV and SARS-CoV-2 infection, the discovery of the expansion mechanism of memory CD8+ cells in the lung is expected to lead to the development of new vaccines to induce cellular immunity.
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Immunity angels turn demons – Li Ming's team revealed that tumor-associated macrophages use IRF8 to promote T cell depletion
Time of Update: 2022-11-15
The authors first detected changes in the mononuclear phagocyte system in the MMTV-PyMT (PyMT) breast cancer model, and found that the number of tumor-associated macrophages residing in tumor tissues increased, while the proportion of DC1 decreased, and DC2 did not change significantly。 Most DC1 expresses CD103, a marker associated with maturation and migration to secondary lymph nodes.
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Single-cell RNA-seq reveals cancer pain: a subset of neuron-like macrophages associated with cancer pain
Time of Update: 2022-10-20
Background cancers remain the leading cause of death worldwide. Many patients with malignant tumors endure chronic pain, especially those with advanced lung, breast, prostate or gastrointestinal canc
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Cell: Zhejiang University found that the high-potassium environment in tumors can reshape tumor-associated macrophages
Time of Update: 2022-10-02
1" in the journal Cell Metabolism 。 In both mouse models and human samples, the study demonstrated that intratumor-high K+ regulates the functional polarization of tumor-associated macrophages (TAM) by targeting inward rectifying K+ channel Kir2.
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Embryonic macrophages: monitoring hematopoietic stem cell quality determines hematopoietic clonality
Time of Update: 2022-10-01
The authors studied the blood development of zebrafish embryos and found that hematopoietic stem cells and progenitor cells (HSPCs) emerge from the abdominal wall of the dorsal aorta (VDA), enter the circulatory system, and stay in the embryonic niche, a vascular plexus called caudal hematopoietic tissue (CHT).
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Science provides "quality assurance" for new stem cells: macrophages are responsible for review
Time of Update: 2022-09-30
”Quality assurance of hematopoietic stem cells by macrophages determines stem cell clonality The top two images show a stressful stem cell, shown by the calreticulin (yellow spike) expressed on its surface, which is engulfed and engulfed by macrophages.
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New ideas for tumor single-cell research: discovery and research of new macrophage populations in breast cancer
Time of Update: 2022-08-30
Therefore, the researchers used single-cell transcriptome sequencing technology to analyze the heterogeneous characteristics of tumor-associated macrophages and discovered a new subset of anticancer macrophages, which may provide potential targets for macrophage-targeted cancer therapy.
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Nature Cancer of Sun Yat-Sen University found that mitochondrial fission promotes macrophage phagocytosis of cancer cells by regulating phase transition
Time of Update: 2022-08-11
The components WIP and WASP phase transition, thereby promoting the phagocytosis of cancer cells by macrophages , and found that mitochondrial fission changes two important aspects of the phagocytosis machinery .
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Nature Cancer: Reprogrammed macrophages stimulate vascular cells to secrete proteins and promote cancer metastasis
Time of Update: 2022-05-13
The team's experiments in mice transplanted with human breast cancer cells showed that the reprogrammed macrophages stimulated vascular cells to secrete a mix of metastasis-promoting proteins that are part of the metastatic niche .
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Zhou Bin and his team work together to reveal the cell fate and function of pericardial macrophages in cardiac inflammation and repair
Time of Update: 2022-05-09
The researchers of Zhou Bin's group first proved that the newly established dual-homologous recombinase-mediated genetic lineage technology ( CD45-Dre; Gata6-iCreER; R26-tdTomato tool mouse) can be efficiently Specific labeling of macrophages in the pericardial cavity .
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Nat. Commun. Interaction patterns between interstitial cells and macrophages in colorectal cancer tumor borders
Time of Update: 2022-04-17
Youqiong Ye from Shanghai Institute of Immunology, Shanghai Jiao Tong University School of Medicine published a research titled Single-cell and spatial analysis reveal interaction of FAP+ fibroblasts and SPP1+ macrophages in colorectal cancer in Nature Communications thesis .
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Cell sub-issue: Jiang Peng's team from Tsinghua University reports that citrulline metabolism regulates macrophage inflammatory response
Time of Update: 2022-01-25
A recent study by Jiang Peng's group at the School of Life Sciences, Tsinghua University revealed that abnormal changes in the urea cycle significantly affect the ammonia metabolism and polyamine biosynthesis of tumor cells (Li et al.
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Mol Cell Jiang Peng's research group reports that citrulline metabolism regulates the inflammatory response of macrophages
Time of Update: 2022-01-25
A recent study by Jiang Peng's group at the School of Life Sciences, Tsinghua University revealed that abnormal changes in the urea cycle significantly affect the ammonia metabolism and polyamine biosynthesis of tumor cells (Li et al.
006 Reprint notice [Non-original article] The copyright of this article belongs to the author of the article.
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Front Cell Dev Biol: HSA_CIRC_0000652 aggravates the inflammatory response in ankylosing
Time of Update: 2022-01-22
Numerous studies have shown that circRNAs are differentially expressed and function in various rheumatic and inflammatory diseases, such as osteoarthritis (OA), systemic lupus erythematosus, and rheumatoid arthritis .
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Use CRISPR technology to modify tumor cells in situ and reshape macrophages to achieve effective tumor immunotherapy
Time of Update: 2022-01-08
722 ) in the field of nanotechnology published an online publication titled " CRISPR-based in situ engineering tumor cells to reprogram macrophages for effective cancer" " Immunotherapy " (using CRISPR technology to modify tumor cells in situ to reshape macrophages to achieve effective tumor immunotherapy) research results .