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proteins from the Golgi apparatus to cell membranes and proposed a method to inhibit EGFR-dependent tumor growth...
Time of Update: 2022-10-20
On October 12, 2022, the Guo Huiling Experimental Group of the School of Life Sciences of Xiamen University and the Zhao Tongjin Research Group of the Institute of Metabolic and Integrative Biology of Fudan University jointly published a study entitled Targeting EGFR-dependent tumors by disrupting an ARF6-mediated sorting system in Nature Communications A sorting mechanism of palmitoylation modification-mediated proteins from the Golgi apparatus to cell membranes was revealed, and an effective strategy for inhibiting EGFR-dependent tumor growth was also proposed.
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The José C. Pastor-Pareja group of the School of Life Sciences reported on the structure of the endoplasmic reticulum-Golgi apparatus in Drosophila
Time of Update: 2021-10-21
Pastor-Pareja research group of the School of Life Sciences of Tsinghua University published a titled "There are a large number of vesicles and beaded tubules at the exit of the endoplasmic reticulum of fruit flies, but no "ER exit sites in Drosophila display abundant ER-Golgi vesicles and pearled tubes but no megacarriers)".
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Nature Cell Biology: Golgi-derived vesicles regulate the division of endosomes
Time of Update: 2021-08-07
On June 28, 2021, Associate Researcher Jia Shunji (Professor Anming Meng’s team) from the School of Life Sciences of Tsinghua University and the laboratory of Researcher Li Dong from the Institute of Biophysics of the Chinese Academy of Sciences published a titled "Golgi secretory vesicles by promoting phosphatidylinositol" on Nature Cell Biology.
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Chinese Academy of Sciences, Tsinghua University Nature publication found that Golgi-derived SEC14L2 vesicles regulate endocytosis division
Time of Update: 2021-08-06
June 28, 2021, Tsinghua University School of Life Jia Shunji associate researcher (Professor Meng Anming team) Joint Institute of Biophysics Laboratory researcher Li Dong in " Nature the Cell Biology on" a speech entitled "Golgi secretory vesicles through the promotion of phosphatidylinositol Inositol conversion mediates endosome fission (A Golgi-derived vesicle potentiates PtdIns4P to PtdIns3P conversion for endosome fission)" research paper .
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Study found the first RNA silencing suppressor located in the Golgi apparatus
Time of Update: 2021-08-01
Photo courtesy of the Institute of Plant Protection, Chinese Academy of Agricultural Sciences, the tomato yellow leaf curl virus genome encodes multiple conservative open reading frames .
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) are the cause of STING co-ligand and STING translocation to Golgi activation
Time of Update: 2021-04-23
Fang Run and Jiang Qifei from the laboratory of Jiang Zhengfan cleverly used the self-activating mutant of STING to induce cell death, and performed a CRISPR-Cas9-mediated genome-wide screening in diploid cells HT1080 , Found that a number of key genes involved in the synthesis of sulfated glycosaminoglycans (mucopolysaccharides) are highly enriched (Figure 1).
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Research reveals new functions of Golgi membrane protein PAQR11 on lipid metabolism and immune regulation
Time of Update: 2021-03-23
Recently, the research group of Chen Yan, a researcher at the Shanghai Institute of Nutrition and Health, Chinese Academy of Sciences, published articles on Molecular Metabolism and Immunology, revealing the role of the membrane protein PAQR11, located in the organelle Golgi, in fat metabolism and immune regulation.
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Separation of the Plant Golgi Apparatus and Endoplasmic Reticulum by Free-Flow Electrophoresis
Time of Update: 2021-03-16
Free-flow electrophoresis (FFE) is a technique for separation of proteins, peptides, organelles, and cells.
Here we describe complete separation between the ER and more negatively charged Golgi compartments using ZE-FFE.
We also describe techniques for assigning proteins to partially separated ER and the less negatively charged Golgi compartments.
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Fluorescent Microscopy as a Tool to Elucidate Dysfunction and Mislocalization of Golgi Glycosyltransferases in COG Complex Depleted Mammalian Cells
Time of Update: 2021-01-04
Here we detail a combination of fluorescent lectin and immuno-staining in cells depleted of COG complex subunits to examine the status of Golgi glycosyltransferases.
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Proteomic Analysis of the Stacked Golgi Complex
Time of Update: 2020-12-29
The Golgi complex is the central organelle of the secretory pathway and functions to posttranslationally modify newly synthesized proteins and lipids and to sort them to their sites of function.
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Insights into the SequenceFunction Relationships of Golgi-Glycosyltransferases
Time of Update: 2020-12-18
In this chapter, we extend our phylogenetic studies to the comparative analysis of the environment of sialyltransferase gene loci (synteny and paralogy studies), the variations of tissue expression of these genes and the analysis of amino-acid position evolution after gene duplications, in order to assess their sequence–function relationships and the molecular basis underlying their functional divergence.