The Hujiazhi research team has developed new methods for optimizing gene editing and tracking DNA
Time of Update: 2021-03-15
The study describes a new method that can be used to quantify both Cas9 editing efficiency and off-target activity, as well as the chromosomal abnormal structure caused by editing, or primer-extension-mediated sequencing (PEM-seq).
Scientists have revealed that DNA re-methylation leads to abnormal development of sochi cell
Time of Update: 2021-03-12
Recently, Professor Gao Shaorong and Professor Zhang Yong of Tongji University School of Life Sciences and Technology conducted a genome-wide DNA methylation group high-volume sequencing analysis of different developmental destiny somatic cell
"Dark matter" DNA affects brain development
Time of Update: 2021-03-07
By removing some of these "ultraconservative elements," the researchers found that these sequences fine-tune the gene expression of encoded proteins to guide brain development.
Major and Modified Nucleosides, RNA, and DNA
Time of Update: 2021-03-06
HPLC has proved to be a very effective, broadly applicable chromatographic method for the separation and analysis of complex molecules in fields as diverse as biochemistry and environmental, pharmaceutical, medical, and polymer chemistry.
Cell Stem Cell Interpretation! Scientists have developed a new DNA therapy that promises to remove
Time of Update: 2021-03-04
used ION251 to remove myeloma stem cells without damaging healthy blood cells. 'These preclinical results are so striking that half of the microscope images we compared bone marrow samples between treated mice and untreated mice have been blank
Scientists have discovered new mechanisms for RNA methylation to regulate sperm development
Time of Update: 2021-03-02
of mettl3 A (6-thyroid gland) modifies the new mechanism that regulates the starting process of differentiation and subtracting of spermogen stem cells. The research, titled Metall3-mediated m A regulates spermatogonial and meio launchsision
An effective method of completely removing contaminating genomic DNA from an RNA sample to be used for PCR
Time of Update: 2021-02-25
This method produces an RNA sample that is negative for genomic DNA byPCR .
The Development and Use of Repetitive Sequences as DNA Probes for Parasite Detection and Species Identification
Time of Update: 2021-02-24
The use of DNA probes for the detection and identification of para sites has become a routine practice in many laboratories and the tech nique is rapidly becoming established as a diagnostic tool for field and clinical studies. DNA
Development of Bacterial Species-Specific DNA Probes Based on Ribosomal RNA Genes Using PCR
Time of Update: 2021-02-24
to develop DNA probes for specific bacteria that include the use of genes for antigenic determinants and virulence factors, randomly cloned DNA fragments, high copy number sequences including insertion elements, and ribosomal RNA (rRNA) genes ( 1
The viral RNA polymerase inhibitor AT-527 treats COVID-19, and Chugai Pharmaceuticals will be responsible for the development and sale in Japan
Time of Update: 2021-02-23
Japan's Chugai Pharmaceutical Co., Ltd. announced today that it has reached a licensing agreement with Roche to develop and market a new oral anti-COVID-19 candidate drug, AT-527, in Japan.
Preparation of DNA and RNA from Trypanosoma brucei
Time of Update: 2021-02-12
and subsequently the salivary glands of the tsetse fly ( Glossina spp.) vector. Most laboratory work has concentrated on two of these life cycle stages; rodent-adapted blood- stream forms propagated by syringe passage, and cultured procyclic
The relationship between DNA packaging proteins and tumor development was found
Time of Update: 2021-02-07
Scientists from the University of Otago have discovered a three-dimensional structure of two proteins that provide an answer to why some people develop certain specific cancers. a new study published in Nature Communications, a team led by Dr
RNA Extraction from Developing or Mature Wheat Seeds
Time of Update: 2021-01-17
Purification of RNA from plant tissue especially from seed tissue can be challenging due to this high starch content.
Development of an Efficient Inverse PCR Method for Isolating Gene Tags from T-DNA Insertional Mutants in Rice
Time of Update: 2021-01-16
The central goal of current genomics research in plants, as in other organisms, is to elucidate the functions of every gene.
Analysis of Small RNA Populations Using Hybridization to DNA Tiling Arrays
Time of Update: 2021-01-14
We first designed a control experiment with eightcDNA clones corresponding to sequences located on chromosome 4 and obtained robust and specific hybridization signals.
Pharmaceutical Mingsheng Foundation introduces high-quality and cost-effective research and development and GMP prosite DNA production services
Time of Update: 2021-01-10
biopharmaceutical companies developing high-end therapeutic drugs have a reliable and controlled supply chain of granulated DNA that better protects their clinical research and commercial production of raw materials.
In Vitro Selected RNA-Cleaving DNA Enzymes From Combinatorial Libraries
Time of Update: 2021-01-06
We have designed a strategy to identify accessible cleavage sites in human immunodeficiency virus-1 (HIV-1) gag RNA from a pool of random DNA enzymes, and for isolation of DNA enzymes.
The Russian Ministry of Economic Development explained the necessity of imposing export tariffs on soybeans
Time of Update: 2021-01-04
ministry explained that the tariff measures would help to increase the utilization rate of soybean processing facilities and curb the rise in the price of soybean processing products (soybean oil and soybean meal).
Detection of Mutations in DNA and RNA by Chemical Cleavage
Time of Update: 2021-01-02
Thus, this method almost guarantees detection of all mutations by cleavage at mismatched or unmatched (for deletions or insertions) bases.
Cell Death Dis: New ring RNA circXPO1 promotes the development of lung adenocarcinoma
Time of Update: 2020-12-23
previous studies have shown that non-coded RNA (ncRNA) plays a vital role in all types of cancer.