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tRNA-MaP: next-generation DNA sequencing for functional analysis of RNA-associated enzymes
Time of Update: 2023-02-03
Overview of tRNA-MaPThe genetic information encoded in genomic DNA is transcribed into mRNA, which is then transferred during protein synthesis (tRNAs) to decode codons on the mRNA.
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tRNA-m1A modification modulates the function of CD4+ T cells
Time of Update: 2022-10-12
Recently, Li Huabing, a researcher at Shanghai Jiao Tong University School of Medicine, Professor Yi Chengqi of the School of Life Sciences of Peking University, Wu Yuzhang of the Army Military Medical University, and Richard Flavell of Yale University School of Medicine, collaborated with a team entitled "tRNA-m1A modification promotes T cell expansion via efficient MYC protein.
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Yi Chengqi and collaborators in the School of Life Sciences report a new mechanism by which tRNA
Time of Update: 2022-10-12
TRMT61A-mediated tRNA-m1A58 modification is a "translation checkpoint" for CD4+ T cell activation and proliferation regulationDr. Liu Yongbo, Associate Researcher Zhou Jing and Master Candidate Shi Jintong of Shanghai Jiao Tong University School of Medicine, Xiaoyu Li (now a researcher at Zhejiang University School of Medicine) and doctoral student Zhang Xiaoting of the School of Life Sciences of Peking University are the co-first authors of this paper, and Li Huabing, Yi Chengqi, Wu Yuzhang and Richard A.
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Nat Immunol Li Huabing/Yi Chengqi/Wu Yuzhang et al. report a new mechanism of tRNA-m1A modification to regulate the function of CD4+ T cells
Time of Update: 2022-10-01
On September 22, 2022, a team of researchers Li Huabing of Shanghai Jiao Tong University School of Medicine/Shanghai Institute of Immunology, Professor Yi Chengqi of the School of Life Sciences of Pek
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Substrate selection mechanism and function of human cytoplasmic tRNA t6A modification
Time of Update: 2022-03-07
TRS_Editor A{font-family:;font-size:12pt;}> On February 1, the international academic journal Nucleic Acids Research published online the latest collaborative research results "Commonality and diversity in tRNA" by Zhou Xiaolong's group and Wang Enduo's group from the Center for Excellence in Molecular Cell Science (Institute of Biochemistry and Cell Biology), Chinese Academy of Sciences.
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Qi Yijun's research group from the School of Life Sciences discovered the function of tRNA-derived small RNAs in plant antifungal defense responses
Time of Update: 2021-11-01
Qi Yijun’s group from the School of Life Sciences, Tsinghua University used a newly developed small RNA sequencing method to systematically analyze the 5′ tRNA halves and 5′ tsRNAs in the model plant Arabidopsis thaliana, and found that 5′ tsR-Ala regulates the expression of the target gene CYP71A13 and The synthesis of phytoalexins, thereby regulating the plant's antifungal defense response .